Tachycardia-induced cardiomyopathy refers to changes in cardiac structure and function that result from rapid arrhythmia can manifest as a continuous or recurrent event. Cardiomyopathy induced by atrial tachycardia is typically reversible if the effectively controlled. There are few literature reports of tachycardia-induced children, fewer cases have been treated radiofrequency catheter ablation children. we conducted clinical summary 7 children Wuhan Children's Hospital investigate...

Abstract Objectives This study aimed to evaluate the therapeutic efficacy of telitacicept based on conventional treatment in adults with idiopathic inflammatory myopathy (IIM), focusing its impact clinical manifestations. Methods IIM patients who had been treated for at least 3 months from January 2023 2024 were included this study. The response was determined ACR/EULAR criteria minimal, moderate and major improvement Total Improvement Score. Disease activity monitored using core set...

Objectives: The present study aimed to compare the clinicopathological features of patients with seronegative immune-mediated necrotizing myopathy (IMNM) and those positive for anti-signal recognition particle (SRP) or anti-3-hydroxy-3-methylglutarylcoenzyme-a reductase (HMGCR) antibodies. Methods: We retrospectively analyzed data IMNM treated in Neurology Department Tongji Hospital from January 1, 2013, December 31, 2019. Results: Among 117 IMNM, 30.8% (36/117) were anti-SRP antibodies,...

Objectives: Endoplasmic reticulum (ER) stress plays pivotal roles in the regulation of skeletal muscle damage and dysfunction multiple disease conditions. We postulate activation ER idiopathic inflammatory myopathies (IIM). Methods: Thirty-seven patients with immune-mediated necrotizing myopathy (IMNM), 21 dermatomyositis (DM), 6 anti-synthetase syndrome (ASS), 10 controls were enrolled. The expression stress-induced autophagy pathway was detected using histological sections, Western blot,...

Severe cases of coronavirus disease 2019 (COVID-19) among pediatric patients are more common in children less than 1 year age. Our aim is to address the underlying role immunity and inflammation conditions different age groups patients.We recruited confirmed moderate COVID-19 symptoms, admitted Wuhan Children's Hospital from January 28th April 1st 2020. Patients were divided into four (≤ 1, 1-6, 7-10, 11-15 years). Demographic information, clinical characteristics, laboratory results...

To identify the factors that predict remission and relapses in myasthenia gravis (MG) patients improved by prednisone tacrolimus treatment.A retrospective, observational cohort analysis of MG who achieved after receiving were performed at Tongji Hospital. The main outcome measures time to remission, discontinuation, reduction-associated relapse, treatment outcome.After adding tacrolimus, 256 able achieve with a mean 2.1 ± 1.4 months. After median follow-up 2.9 years, 167 (65.2%) discontinued...

αν and β1 integrins mediate Aβ–induced neurotoxicity in primary hippocampal neurons. We treated neurons with 2.5 µg/mL 17E6 5 ab58524, which are specific integrin antagonists, respectively, for 42 h prior to 10 µM Aβ treatment. Next, we employed small interfering RNA (siRNA) silence focal adhesion kinase (FAK), a downstream target gene of integrins. The siRNAs were designed sequence, an MOI the addition polybrene. Under these conditions, transfected apoptosis different cell types was...

Abstract Idiopathic inflammatory myopathies (IIM) is a group of heterogeneous autoimmune systemic diseases, which not only involve skeletal muscle but also myocardium. Cardiac involvement in IIM, eventually develops into heart failure, difficult to identify by conventional examinations at early stage. The aim this study was investigate if multi-parametric cardiac magnetic resonance (CMR) imaging can screen for compared with clinical score (Myositis Disease Activity Assessment Tool, MDAAT)....

Patients who received allogeneic haematopoietic stem cell transplantation (allo-HSCT) may develop T cell-mediated immunologic injury to muscles, recapitulating the characteristics of polymyositis clinically and pahtologically. Polymyositis is a rarely reported complication graft-versus-host disease (GVHD), which often responds well corticosteroids immunosuppressive treatment.

Abstract Background Central nervous system overlapping autoimmune syndromes are uncommon, especially with the coexistence of MOG-IgG and GFAP-IgG. Case presentation A 23-year-old woman presented transient convulsions, a loss consciousness, persistent fever, headache, vomiting. Cerebrospinal fluid (CSF) analysis revealed elevated cellularity, magnetic resonance imaging (MRI) showed diffuse leptomeningeal enhancement. She had fever headache antiviral antibiotic treatment for 2 weeks, she...

The immunological features between neuromyelitis optica spectrum disorder (NMOSD), multiple sclerosis (MS), and myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD), lacked systemic comparisons. Accordingly, we aimed to investigate differences NMOSD, MS, MOGAD.Patients with MOGAD, NMOSD who received tests including cytokine profiles cytometry analysis of the lymphocyte subgroups were retrospectively reviewed divided into training validation sets. Discriminatory models...

Abstract Background Scedosporium apiospermum ( S. ) is a rare fungal pathogen that causes disseminated infections. It rarely affects immunocompetent individuals and has poor prognosis. Case presentation A 37-year-old woman presented with multiple lesions in the lungs, brain, eyes, shortly after near drowning car accident. The primary symptoms were chest tightness, limb weakness, headache, vision left eye. infection was confirmed by metagenomic next-generation sequencing (mNGS) of...

BACKGROUND Immune-mediated necrotizing myopathy (IMNM) is a relatively new proposed category of idiopathic inflammatory myopathies (IIMs), characterized by the presence abundant necrotic muscle fibers, myophagocytosis, and sparse infiltrates. The aim our study was to analyze immunopathological characteristics IMNM detecting biopsy samples from cohort patients, delineate pathways involved in pathogenesis. MATERIAL AND METHODS A retrospective evaluation samples, clinical laboratory data,...

The aim of this study was to elucidate the clinical and myopathological characteristics patients with anti-signal recognition particle (SRP) positive immune-mediated necrotizing myopathy (IMNM) overlap Sjogren's syndrome (SS).We retrospectively analyzed data anti-SRP IMNM admitted in Neurology Department Tongji Hospital between January 2011 December 2020. Patients were divided into two groups: SS group control group. features, laboratory results, histological treatment, prognosis compared...

To explore and confirm feasibility the T2 maps readout-segmented echoplanar imaging (rs-EPI) diffusion-weighted (DWI) characteristics of thigh muscles for dermatomyositis (DM) patients.This study was approved by University Institutional Review written informed consent obtained from all subjects before enrollment (trial registration number: TJ-C20121221). 28 patients with DM proven diagnostic criteria were enrolled in along 9 healthy control subjects. Conventional MR, rs-EPI DWI Both apparent...

Convexal subarachnoid hemorrhage (cSAH) is characterized by isolated bleeding in one or a few adjacent sulci and has diverse etiologies symptoms. Acute ischemic stroke co-occurring with cSAH been infrequently reported. Nearly all cases of have described to occur on the side acute stroke, it unusual for opposite infarct territory. Our report presents two associated contralateral cSAH. The first patient had left atherosclerotic internal carotid artery (ICA) occlusion developing right parietal...

TNF-like weak inducer of apoptosis (TWEAK) and its sole receptor fibroblast growth factor-inducible 14 (Fn14) are involved in various inflammatory conditions. This study was performed to investigate the potential role TWEAK/Fn14 immune-mediated necrotizing myopathy (IMNM).Muscle biopsies from patients with IMNM (n = 37) controls 11) were collected. Human muscle cells treated TWEAK vitro. Muscle cultured analysed by immunostaining quantitative PCR. Serum levels Fn14 detected ELISA.TWEAK...

<b>Background:</b> It has been reported that R2* is a sensitive marker for iron deposition. The aim of this study was to quantitatively assess deposition in Parkinson's disease (PD) using changes enhanced T2 star-weighted angiography (ESWAN) and discuss the value ESWAN PD.<br><b>Methods:</b> Fifty-four primary PD patients twenty-eight healthy individuals were examined by 3·0 T magnetic resonance imaging system. values measured from deep gray nuclei (including substantia nigra [SN], red...