A5100357713- Intracerebral and Subarachnoid Hemorrhage Research
- Acute Ischemic Stroke Management
- Neurosurgical Procedures and Complications
- Vascular Malformations Diagnosis and Treatment
- Vascular Anomalies and Treatments
- Antiplatelet Therapy and Cardiovascular Diseases
- Pituitary Gland Disorders and Treatments
- Neurofibromatosis and Schwannoma Cases
- Cancer Treatment and Pharmacology
- Cerebrovascular and genetic disorders
- Ion channel regulation and function
- Autophagy in Disease and Therapy
- Cerebrospinal fluid and hydrocephalus
- Neuroscience and Neuropharmacology Research
- Intracranial Aneurysms: Treatment and Complications
- Glioma Diagnosis and Treatment
- Myasthenia Gravis and Thymoma
- Ocular Oncology and Treatments
- Mitochondrial Function and Pathology
- Vascular Malformations and Hemangiomas
First Affiliated Hospital Zhejiang University
2025
Anhui Medical University
2021-2024
Wuxi Taihu Hospital
2024
Huazhong University of Science and Technology
2022
Chinese Institute for Brain Research
2022
Tongji Hospital
2022
Taiyuan Central Hospital
2022
Shanghai Pulmonary Hospital
2021
Kunming Medical University
2016-2017
First Affiliated Hospital of Kunming Medical University
2016-2017
Brainstem hemorrhage (mainly pontine caused by hypertension) has the clinical characteristics of acute onset, rapid progress, high mortality, and disability rate. Due to complexity brainstem's anatomical structure functional importance, it is generally recognized that brainstem treatment difficult risky, so been regarded as a restricted area surgery. However, in recent years, continuous progress being made many areas, including microsurgical technology, stereotactic robot-assisted surgery,...
Abstract Introduction Traumatic brain injury (TBI) is a complex pathophysiological process, and increasing attention has been paid to the important role of post‐synaptic density (PSD) proteins, such as glutamate receptors. Our previous study showed that PSD protein Arc/Arg3.1 (Arc) regulates endoplasmic reticulum (ER) stress neuronal necroptosis in traumatic vitro. Aim In this study, we investigated expression, regulation biological function Arc both vivo vitro experimental TBI models....
The degree of early brain injury (EBI) is a significant factor that affects the prognosis patients with subarachnoid hemorrhage (SAH). Evidence has shown fibroblast growth factor-2 (FGF-2) may alleviate serious consequences EBI after SAH. objective current study was to investigate underlying mechanism mediates neuroprotective effects FGF-2 in SAH rat model. Sprague-Dawley (SD) rats underwent different treatments were divided into various groups. administered intranasally treatment group...
Spontaneous intracerebral hemorrhage (ICH) is a subtype of stroke with high mortality and morbidity due to the lack effective therapies. The alpha‑amino‑3‑hydroxy‑5‑methyl‑4‑isoxazolepropionic acid receptor antagonist perampanel has been reported alleviate early brain injury following subarachnoid traumatic by reducing reactive oxygen species, apoptosis, autophagy, necroptosis. Necroptosis caspase‑independent programmed cell death mechanism that serves vital role in neuronal ICH. However,...
Background: Whether primary brainstem hemorrhage (PBH) should be treated with a conservative treatment or surgical intervention (such as craniotomy, puncture, and drainage) is still controversial. The aim of this study was to assess the feasibility safety puncture drainage for PBH assistance robot. Patients Methods: A total 53 patients diagnosed were included in study. They divided into nonsurgical groups. All group underwent assisted robots at Beijing Jingmei General Hospital from June 2017...
Nearly 10% to 20% of myasthenia gravis (MG) patients are refractory conventional treatment for unclear reasons. The study aimed explore the relationship between drug metabolism gene polymorphisms and MG.One hundred thirty-one MG (33 in group; 98 non-refractory group) admitted Tongji Hospital were included this retrospective study. Improved multiplex ligation detection reaction (iMLDR) was used genotype 13 (NR3C1 rs17209237, rs9324921; FKBP5 rs1360780, rs4713904, rs9296158; HSP90AA1...
Abstract Background Optic nerve astrocytomas (ONAs) are neurological neoplasms in the central nervous system (CNS), and they have highest incidence rate among all tumor types visual pathway. In this study, we conducted a Surveillance, Epidemiology, End Results (SEER) -based research to explore demographic, survival, prognostic factors of patients diagnosed with ONAs. Methods Utilizing SEER database, retrospectively evaluated data ONAs ages from 1984 2016. We used Student’s t distribution...
Antihypertensive therapy in the acute phase of intracerebral hemorrhage (ICH) can reduce hematoma expansion. Numerous studies have demonstrated that blood pressure variability secondary to antihypertensive has adverse effects on neurological outcomes, but conclusions are diverse, and mechanism this occurrence is unknown. The aim research was analyze impact after treatment prognosis patients with ICH, along possible mechanism.A total 120 within 20 h onset ICH were divided into a good group...
Objective To evaluate the efficacy and feasibility of radiofrequency ablation(RFA) for complicated diffuse arteriovenous malformations. Methods From Dec. 2014 to 2016, 12 cases with arterioveneous malformations were treated by RFA in our hospital. The clinical records retrospectively reviewed. lesion size ranged from 10 cm×7 cm 28 cm×30 cm. Ablation procedures high power long time technique performed under real color Doppler monitoring. impedance model used ablation needles punctured...