A5060337779- Hepatocellular Carcinoma Treatment and Prognosis
- Advanced biosensing and bioanalysis techniques
- Liver Disease Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Cancer Mechanisms and Therapy
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer, Lipids, and Metabolism
- Nanoplatforms for cancer theranostics
- Acoustic Wave Resonator Technologies
- RNA Interference and Gene Delivery
- Extracellular vesicles in disease
- Liver physiology and pathology
- Nutrition and Health in Aging
- Radiomics and Machine Learning in Medical Imaging
- Hepatitis C virus research
- Advanced Nanomaterials in Catalysis
- Gas Sensing Nanomaterials and Sensors
- Frailty in Older Adults
- Theoretical and Computational Physics
- CRISPR and Genetic Engineering
- Nanocluster Synthesis and Applications
- Pickering emulsions and particle stabilization
- Glass properties and applications
- Biosensors and Analytical Detection
- Mesenchymal stem cell research
Mengchao Hepatobiliary Hospital
2020-2025
Fujian Medical University
2020-2025
Fuzhou University
2020-2024
First Affiliated Hospital of Fujian Medical University
2020-2024
Southern Medical University
2021
Ca' Foscari University of Venice
1993-1995
Nanjing Institute of Technology
1991
Point-of-care testing (POCT) technology has made major breakthroughs in community medicine and physician office situations, tandem with the more ubiquitous intensive usage of highly integrated quick detection equipment for illness diagnosis, personal care, mobile healthcare. Although photoelectrochemical (PEC)-based POCT platform offers benefits cheap cost good user engagement, its commercialization is still limited by photodetection components' downsizing mobility, among other factors. In...
Recently emerged Z-scheme heterostructure-based immunoassays have presented new opportunities for photoelectrochemical (PEC) biosensing development. Here, we described a tunable signal-on PEC biosensor the detection of cardiac troponin I (cTnI), which exploited competitive absorption effect between Cu(II) ions and Zr metal-organic framework (Zr-MOF) constructed on TiO2 nanorods (Cu2+@Zr-MOF@TiO2 NRs). Water-stable Zr-MOF was coated onto NRs fluorine-doped tin oxide to form heterostructure...
This study reports a photoelectrochemical biosensor for dopamine-loaded liposome-encoded magnetic beads cleaved by CRISPR/Cas 12a system the quantification of human papilloma virus-related DNA using neodymium-doped BiOBr nanosheets.
Functional photothermal nanomaterials have gained widespread attention in the field of precise cancer therapy and early disease diagnosis due to their unique conversion properties. However, relatively narrow temperature response range outputable accuracy commercial thermometers limit accurate detection biomarkers. Herein, we designed a liposome-embedded Cu2-xAgxS amplification-based sensor for determination cardiac troponin I (cTnI) health monitoring point-of-care testing (POCT). The...
Herein, we developed a flexible, low-cost thermosensitive fiber paper for the visual display in photothermal biosensing systems early acute myocardial infarction. The thermal signal visualization device was encapsulated with rewritable fibers, which exhibited excellent stability and reversibility. mechanism of color change based on temperature-driven reversible transformation structure dye molecule (crystalline violet lactone, CVL). It exhibits gradation from blue to colorless at higher...
Abstract A paper‐based naked‐eye recognition assay with enzyme‐encapsulated protein engineered metal–organic framework‐derived biominerals is developed for direct quantification of sarcosine in urine samples screening prostate cancer individuals. The detection strategy stems from the successful construction a cascade response model, which involves introduction enzymatic catalytic reaction on Pt nanoparticles (NPs)‐loaded porous CeO 2 by integrating oxidase as special unit and chromogenic...
Abstract Acute myocardial infarction (AMI) survivors face a high risk of mortality as result increasing heart failure and irreparable injury. New portable methods for immediate diagnosis must be developed to provide patients with daily warnings. Herein, the development dual‐mode photothermal‐pyroelectric output system based on point‐of‐care platform rapid AMI detection is reported. Termed Integrated Photothermal‐Pyroelectric Biosensor (IPPBA), method leverages cascade enzymatic amplification...
LBA522 Background: Transarterial chemoembolization (TACE) has been established as a standard treatment for hepatocellular carcinoma (HCC) eligible embolization. Combining immunotherapy and tyrosine kinase inhibitors (TKIs) with TACE can potentially enhance antitumor activity by activating the immune system inhibiting tumor neovascularization. This study investigated whether addition of camrelizumab apatinib to could bring better survival benefits. Methods: open-label, randomized phase 2...
Abstract Growing evidences have proved that tumors evade recognition and attack by the immune system through escape mechanisms, PDL1/Pbrm1 genes a strong correlation with poor response or resistance to checkpoint blockade (ICB) therapy. Herein, multifunctional biomimetic nanocarrier (siRNA‐CaP@PD1‐NVs) is developed, which can not only enhance cytotoxic activity of cells blocking PD1/PDL1 axis, but also reduce tumor via Pbrm1/PDL1 gene silencing, leading significant improvement in...
Immune checkpoint inhibitors represented by PD-1/PD-L1 monoclonal antibodies have shown great success in tumor immunotherapy. However, the response rate of immune blockade (ICB) therapy alone is far from satisfactory due to insufficient and exhausted tumor-infiltrating T cells. Meanwhile, antibody-based drugs some drawbacks such as high cost complicated preparation, which require further development nonantibody more rational strategies for improving effectiveness treatment. Here, a highly...
Background HCC is a major global health issue, especially in China. Most cases are diagnosed at an advanced stage, making resection unfeasible. Systemic therapies like lenvatinib and sorafenib have been used as treatment options, but emerging combination showing more promise. Triple therapy, which combines local systemic treatments, has demonstrated higher response rates. However, the optimal of bevacizumab triple therapy for remains uncertain.Note: This GPT best alongside editGPT Browser...
A zirconium oxide aerogel with a 70% by weight degree of crystallinity was prepared from n-propoxide an excess water being used in the hydrolysis process. The small-angle X-ray scattering (SAXS) technique revealed that this system had mass-fractal character. elementary building blocks size about 50 Å and displayed nonfractal (smooth) boundary surface. dimension, Dm, found SAXS to be equal 1.95 (5). novelty fractal lies fact are made up particles high (preponderantly tetragonal form)....
e16269 Background: Hepatocellular carcinoma (HCC) management in very elderly individuals, particularly those considering hepatectomy, demands a balanced evaluation of surgical safety and survival outcomes. This multicenter study aims to elucidate the influence preoperative frailty, as determined by Clinical Frailty Scale (CFS), on both short-term long-term outcomes octogenarians undergoing hepatectomy for HCC. Methods: We conducted retrospective analysis cohort (≥ 80 years) who underwent HCC...
e16268 Background: As laparoscopic hepatectomy (LH) gains traction in the surgical management of hepatocellular carcinoma (HCC), its efficacy for exophytic HCC, a subtype with unique challenges, remains under scrutiny. This study aims to compare long-term outcomes LH traditional open (OH) treating HCC. Methods: A multicenter retrospective analysis was conducted on patients solitary HCC undergoing or OH at 10 hepatobiliary centers. Propensity score matching (PSM) and inverse probability...
e16254 Background: With the increasing prevalence of hepatic resection for hepatocellular carcinoma (HCC) in elderly, understanding impact preoperative frailty on surgical outcomes is crucial. This multicenter cohort study investigates association between and both short- long-term post-hepatic elderly HCC patients. Methods: involved patients (≥ 70 years) undergoing curative-intent at 10 hospitals China from 2012 to 2021. Frailty was assessed using Clinical Scale (CFS), with a score ≥5...
e16168 Background: HCC pts with active HBV infection were excluded from most clinical trials involving immune checkpoint inhibitors because of safety concerns. We are aiming to evaluate the treatment atezo/bev in TALENTop study (NCT04649489) which enrolled a large number infection. Methods: The is clarify whether liver resection may provide additional benefits Chinese macrovascular invasion who responded conversion therapy atezo/bev. After two versions protocol modification, allowed. This...
Up to half of hepatocellular carcinoma (HCC) cases are diagnosed at an advanced stage, for which effective treatment options lacking, resulting in a poor prognosis. Over the past few years, combination immune checkpoint inhibitors and anti-angiogenic targeted therapy has proven highly efficacious treating HCC, significantly extending patients' survival providing potential sequential curative surgery. After hepatectomy or liver transplantation following conversion therapy, patients can...