A5089238756- Hepatocellular Carcinoma Treatment and Prognosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer, Lipids, and Metabolism
- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Pancreatic and Hepatic Oncology Research
- Gallbladder and Bile Duct Disorders
- Cancer Mechanisms and Therapy
- Radiomics and Machine Learning in Medical Imaging
- Cancer-related molecular mechanisms research
- Hepatitis C virus research
- Inflammatory Biomarkers in Disease Prognosis
- Liver Disease and Transplantation
- Ferroptosis and cancer prognosis
- Renal cell carcinoma treatment
- Cancer Immunotherapy and Biomarkers
- Organ Transplantation Techniques and Outcomes
- RNA modifications and cancer
- Glutathione Transferases and Polymorphisms
- Occupational and environmental lung diseases
- Cancer Genomics and Diagnostics
- Liver physiology and pathology
- Genetic factors in colorectal cancer
- Gastric Cancer Management and Outcomes
- Pediatric Hepatobiliary Diseases and Treatments
Fujian Medical University
2019-2025
Mengchao Hepatobiliary Hospital
2019-2025
First Affiliated Hospital of Fujian Medical University
2021-2024
Predict (France)
2024
Second Military Medical University
2015-2022
Affiliated Hospital of North Sichuan Medical College
2022
Yong In University
2022
Hangzhou Medical College
2022
Zhejiang Provincial People's Hospital
2022
Southern Medical University
2021
Systemic analyses using large-scale genomic profiles have successfully identified cancer-driving somatic copy number variations (SCNVs) loci. However, functions of vast focal SCNVs in "protein-coding gene desert" regions are largely unknown. The integrative analysis long noncoding RNA (lncRNA) expression with hepatocellular carcinoma (HCC) led us to identify the recurrent deletion lncRNA-PRAL (p53 regulation-associated lncRNA) on chromosome 17p13.1, whose alterations were significantly...
Downregulation of Aldolase B (ALDOB) has been reported in hepatocellular carcinoma. However, its clinical significance and role pathogenesis HCC remain largely unknown.We analyzed the expression ALDOB features a large cohort 313 patients using tissue microarray immunohistochemistry. Moreover, function stably overexpressed cells was explored vitro vivo. Gene analysis performed on ALDOB-overexpressing SMMC7721 to elucidate mechanism action.ALDOB downregulation significantly correlated with...
Early recurrence is common for hepatocellular carcinoma (HCC) after surgical resection, being the leading cause of death. Traditionally, COX proportional hazard (CPH) models based on linearity assumption have been used to predict early recurrence, but predictive performance limited. Machine learning offer a novel methodology and several advantages over CPH models. Hence, purpose this study was compare random survival forests (RSF) model with in prediction HCC patients curative resection.A...
Background: The high incidence of early recurrence after liver resection for hepatocellular carcinoma (HCC) is the main obstacle in achieving good long-term survival outcomes. aim present study to develop a prognostic model predicting risk very (1-year) recurrence. Material and Methods: Consecutive patients who underwent HCC with curative intent at multi-centers China were enrolled this study. VERM-pre (the Preoperative Very Early Recurrence Model HCC) performance was derived validated by...
The presence of microvascular invasion (MVI) is a significant malignant pathological feature related to recurrence and survival after liver resection for hepatocellular carcinoma (HCC). This study aimed investigate the relationship between severity in grading MVI long-term oncological outcomes patients with early-stage HCC.A retrospective was conducted on prospectively maintained multicenter database who underwent curative Barcelona Clinic Liver Cancer stage 0/A HCC 2017 2020. Patients were...
Abstract Background The Milan criteria and the French α-fetoprotein (AFP) model have both been validated for predicting outcomes after liver transplantation hepatocellular carcinoma, with also used hepatic resection. aim of this study was to evaluate AFP model's predictive value recurrence survival following carcinoma resection compare its performance that criteria. Methods Data patients who underwent between 2002 2021 were analysed. For criteria, divided into two groups: those within beyond...
Abstract Purpose We aimed to develop and validate a radiomics model for differentiating hepatocellular carcinoma (HCC) from focal nodular hyperplasia (FNH) in non-cirrhotic livers using Gd-DTPA contrast-enhanced magnetic resonance imaging (MRI). Methods retrospectively enrolled 149 HCC 75 FNH patients treated between May 2015 2019 at our center. Patients were randomly allocated training ( n =156) validation set =68). In total, 2260 features extracted the arterial phase portal venous of MRI....
Abstract Background The value of serum biomarkers, particularly alpha-fetoprotein (AFP) and protein induced by vitamin K absence or antagonist-II (PIVKA-II), gains increasing attention in prognostic evaluation recurrence monitoring for patients with hepatocellular carcinoma (HCC). This study investigated the implications serological incomplete conversion (SIC) these 2 biomarkers as indicators long-term outcomes after HCC resection. Methods A multicenter observational was conducted on a...
Impact of pathological response after preoperative transcatheter arterial chemoembolization (TACE) on incidences microvascular invasion and early tumor recurrence in hepatocellular carcinoma: a multicenter propensity score matching analysis
Abstract Background To study the influence of preoperative transcatheter arterial chemoembolization (TACE) on incidence microvascular invasion (MVI) and long‐term survival outcomes in hepatocellular carcinoma (HCC) patients. Methods Between January 1, 2010 December 2014, consecutive HCC patients who underwent curative liver resection were enrolled this study. Univariable multivariable regression analyses used to identify independent predictive factors MVI. Propensity score matching (PSM) was...
Background Liver metastasis is highly aggressive and immune tolerant, lacks effective treatment strategies. This study aimed to develop a neoantigen hydrogel vaccine (NPT-gels) with high clinical feasibility further investigate its efficacy antitumor molecular mechanisms in combination checkpoint inhibitors (ICIs) for the of liver metastases. Methods The effects on survival intratumor T-cell subpopulation infiltration patients advanced tumors were investigated using Surveillance,...
Purpose: This study aimed to assess the efficacy and safety of adjuvant transarterial chemoembolization (TACE) plus tyrosine kinase inhibitor (TKI) treatment in patients with hepatocellular carcinoma (HCC) a high risk early recurrence after curative resection. Patients Methods: from multiple centres were divided into postoperative TACE (n=57) or without (n=142) TKI administration groups. The disease-free survival (DFS) curve was depicted by Kaplan–Meier method, difference between two groups...
Inflammation is implicated in tumorigenesis and has been reported as an important prognostic factor cancers. In this study, we aimed to develop validate a novel inflammation score (IFS) system based on 12 inflammatory markers explore its impact intrahepatic cholangiocarcinoma (ICC) survival after hepatectomy.Clinical data of 446 ICC patients undergoing surgical treatment were collected from the Primary Liver Cancer Big Data, then served training cohort establish IFS. Furthermore, internal...
Abstract Background Hepatectomy is currently the most effective modality for treatment of intrahepatic cholangiocarcinoma (ICC). The status lymph nodes directly affects choice surgical method and formulation postoperative plans. Therefore, a preoperative judgment node great significance patients diagnosed with this condition. Previous prediction models mostly adopted logistic regression modeling, few relevant studies applied random forests in ICC metastasis (LNM). Methods A total 149 who met...
Prophylactic transarterial chemoembolization (p-TACE) is strongly recommended for hepatocellular carcinoma (HCC) patients with microvascular invasion (MVI), but the potential beneficiaries remain controversial.Data of HCC MVI who underwent R0 resection between December 2013 and 2015 were identified through primary liver cancer big data. Disease-free survival (DFS) overall (OS) compared received p-TACE or not using Kaplan-Meier curves before after propensity scoring match (PSM).A total 695...
// Jie Cai 1, * , Sheng-Xian Yuan Fu Yang 2, Qi-Fei Tao 1 Qing-Guo Xu Zhen-Guang Wang Jian Yu Kong-Ying Lin Zong-Yan Jin-Zhao Ma 2 Chuan-Chuan Zhou Fang Shu-Han Sun Wei-Ping The Third Department of Hepatic Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China Genetics, These authors contributed equally to this work Correspondence to: Zhou, email: ehphwp3@126.com Sun, shsun@vip.sina.com Keywords: paraoxonase 3, hepatocellular carcinoma,...
Abstract Background and objectives Tumor size is one of the most important issues for hepatocellular carcinoma (HCC) treatment prognosis, but classification it still controversial. The aim this study was to screen appropriate cutoffs solitary hepatitis B virus (HBV)-related HCC. Methods A cohort 1760 patients with HBV-related HCC undergoing curative liver resection divided into 11 groups based on tumor in 1-cm interval. minimum p value method used cutoff according overall survival (OS). If...