A5101779489- Hepatocellular Carcinoma Treatment and Prognosis
- Esophageal Cancer Research and Treatment
- Liver Disease Diagnosis and Treatment
- RNA modifications and cancer
- Advanced Image Fusion Techniques
- Image and Video Quality Assessment
- Robotic Mechanisms and Dynamics
- Hepatitis B Virus Studies
- Cancer-related molecular mechanisms research
- Cancer, Lipids, and Metabolism
- Visual Attention and Saliency Detection
- Radiomics and Machine Learning in Medical Imaging
- Vestibular and auditory disorders
- Epigenetics and DNA Methylation
- Color Science and Applications
- Algal biology and biofuel production
- Hepatitis C virus research
- Pancreatic and Hepatic Oncology Research
- Ferroptosis and cancer prognosis
- Ovarian cancer diagnosis and treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Immunotherapy and Biomarkers
- Image Enhancement Techniques
- Neural Networks and Applications
- Nonlinear Partial Differential Equations
Zhongkai University of Agriculture and Engineering
2016-2025
Mengchao Hepatobiliary Hospital
2019-2024
Fujian Medical University
2019-2024
Third Xiangya Hospital
2024
University of South China
2024
Hebei Medical University
2022-2024
Second Hospital of Hebei Medical University
2022-2024
China National Petroleum Corporation (China)
2024
China Post (China)
2024
Sun Yat-sen University
2023
Early recurrence is common for hepatocellular carcinoma (HCC) after surgical resection, being the leading cause of death. Traditionally, COX proportional hazard (CPH) models based on linearity assumption have been used to predict early recurrence, but predictive performance limited. Machine learning offer a novel methodology and several advantages over CPH models. Hence, purpose this study was compare random survival forests (RSF) model with in prediction HCC patients curative resection.A...
Underwater image enhancement plays a critical role in marine industry. Various algorithms are applied to enhance underwater images, but their performance terms of perceptual quality has been little studied. In this paper, we investigate five popular and output quality. To end, have created benchmark, including images enhanced by different ground truth obtained human perception experiments. We statistically analyse the impact various on perceived images. Also, visual provided these is...
It is noteworthy that the Sylvester equation plays a pivotal role in field of industrial intelligence control. To meet demands real-time applications, temporal-dependent equations (TDSEs) are employed to formulate motion planning problems for robot manipulators. Traditionally, classical Zhang neurodynamics (ZN) method utilized address TDSE problems, which encounters challenges associated with inverse matrix computations. In this article, we introduce an inverse-free approach based on energy...
Drug-induced cardiovascular complications are the most common adverse drug events and account for withdrawal or severe restrictions on use of multitudinous postmarketed drugs. In this study, we developed new in silico models systematic identification drug-induced discovery postmarketing surveillance. Specifically, collected covering five types outcomes (hypertension, heart block, arrhythmia, cardiac failure, myocardial infarction) from four publicly available data resources: Comparative...
Accumulating studies have demonstrated the indispensable roles of exosomes and long non-coding RNAs (lncRNAs) in cancer progression tumor microenvironment (TME). However, clinical relevance exosome-related lncRNAs (ER-lncRNAs) esophageal squamous cell carcinoma (ESCC) remains unclear. Three subtypes were identified by consensus clustering 3459 valid ER-lncRNA pairs, which subtype A is preferentially related to favorable prognosis, lower stromal immune scores, higher purity scores. Higher...
Abstract Background Evidence from observational studies suggests an association between chronic obstructive pulmonary disease (COPD) and lung cancer. The potential interactions the immune system lungs may play a causative role in COPD cancer offer therapeutic prospects. However, causal immune-mediated mechanisms remain to be determined. Methods We employed two-sample Mendelian randomization (MR) approach investigate Additionally, we examined whether cell signals were causally related cancer,...
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The assembly of mammalian SWI/SNF chromatin remodeling complexes is developmentally programed, and loss/mutations subunits alter the levels other components through proteolysis, causing cancers. Here, we show that mouse Lsd1/Kdm1a deletion causes dramatic dissolution LSD1 demethylates methylated lysine residues in SMARCC1 SMARCC2 to preserve structural integrity complexes. SMARCC1/SMARCC2 are targeted for proteolysis by L3MBTL3 CRL4
High DHA production cost caused by low titer and productivity of the current Schizochytrium strains is a bottleneck for its application in competition with traditional fish-oil based approach. In this study, atmospheric room-temperature plasma iodoacetic acid dehydroepiandrosterone screening led to three mutants, 6–8, 6–16 6–23 all increased growth accumulations. A LC/MS metabolomic analysis revealed metabolism PPP EMP as well decreased TCA cycle might be relevant biosynthesis mutants....
N7-Methylguanosine (m7G) and long non-coding RNAs (lncRNAs) have been widely reported to play an important role in cancer. However, there is little known about the relationship between m7G-related lncRNAs esophageal squamous cell carcinoma (ESCC). In this study, we aimed find new potential biomarkers construct lncRNA prognostic signature for ESCC. Three molecular clusters were identified by consensus clustering of 963 lncRNAs, which cluster B preferentially related poorer prognosis, higher...
Background: Esophageal cancer is one of the most common malignant tumors with high incidence and mortality rates. Despite continuous development treatment options, prognosis for esophageal patients remains poor. Therefore, there an urgent need new diagnostic therapeutic targets in clinical practice to improve survival cancer. Methods: In this study, we conducted a comprehensive scRNA-seq analysis tumor microenvironment primary elucidate cell composition heterogeneity. Using Seurat,...
This study has developed a methodology for blending in situ gauge precipitation measurements with satellite estimates region, which uses Bayesian spatiotemporal model. A fast and simple procedure is proposed implementing the methodology, consists of four steps that use kriging, expectation-maximization, Sampson-Guttorp methods turn. The evaluation confirmed new method helped to improve quality prediction when available stations are very sparse. For example, training sets size 20, 40, 70 more...
Abstract TERN‐101 is a nonsteroidal farnesoid X‐receptor agonist being developed for the treatment of nonalcoholic steatohepatitis (NASH). We assessed safety, pharmacokinetics (PK), and pharmacodynamics (PD) capsule tablet formulations in healthy volunteers. In randomized, double‐blind, placebo‐controlled study, 38 participants were enrolled randomized to receive placebo or 25‐, 75‐, 150‐mg capsules orally once daily 7 days. separate open‐label PK formulation‐bridging 16 received single...
Lactic acid, formerly thought of as a byproduct glycolysis or metabolic waste produced, has now been identified key regulator cancer growth, maintenance, and progression. However, the results investigations on lactic acid metabolism-related long non-coding RNAs (LRLs) in esophageal squamous cell carcinoma (ESCC) remain inconclusive. In this study, univariate Cox regression analysis was carried out TCGA cohort, 9 lncRNAs were shown to be significantly associated with prognosis. Least absolute...