A5080544783- CRISPR and Genetic Engineering
- RNA modifications and cancer
- Chromosomal and Genetic Variations
- Pluripotent Stem Cells Research
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Telomeres, Telomerase, and Senescence
- Epigenetics and DNA Methylation
- Cardiac Fibrosis and Remodeling
- Cancer Genomics and Diagnostics
- Glycosylation and Glycoproteins Research
- Peptidase Inhibition and Analysis
- Bone Metabolism and Diseases
- Metabolomics and Mass Spectrometry Studies
- Advanced Proteomics Techniques and Applications
- Mesenchymal stem cell research
- Circular RNAs in diseases
- Ubiquitin and proteasome pathways
- Signaling Pathways in Disease
- Reproductive Biology and Fertility
- Plant Genetic and Mutation Studies
- Advanced biosensing and bioanalysis techniques
- Molecular Biology Techniques and Applications
- Polyomavirus and related diseases
- Mechanisms of cancer metastasis
Peking University First Hospital
2025
Peking University
2025
New York University
2021-2024
Sichuan Academy of Agricultural Sciences
2024
Gansu Agricultural University
2023-2024
Nanjing University
2017-2024
Jilin Medical University
2024
Jilin University
2024
NYU Langone Health
2021-2023
Nanjing Medical University
2005-2023
Although numerous long non-coding RNAs (lncRNAs) have been identified in mammals, many of their biological roles remain to be characterized. Early reports suggest that H19 contributes carcinogenesis, including hepatocellular carcinoma (HCC). Examination the Oncomine resource showed most HCC cases express at a level is comparable with liver, tendency toward lower expression. This consistent our previous microarray data and indicates more complicated role needs In this study, expression was...
The characteristics, significance and potential cause of positive SARS-CoV-2 diagnoses in recovered coronavirus disease 2019 (COVID-19) patients post discharge (re-detectable positive, RP) remained elusive.
Reversible N6-methyladenosine (m6A) modifications in messenger RNAs can be categorized under the field of "RNA epigenetics." However, potential role m6A-related genes gastric cancer (GC) prognosis has not been systematically researched. This study was aimed at providing insights into prognostic gene expression, both mRNA and protein levels. Kaplan–Meier (KM) plotter database The Cancer Genome Atlas (TCGA) were used to explore significance individual overall survival (OS) progression-free...
Relapse of membranous nephropathy (MN) and other glomerular diseases has been observed after COVID-19 infection. The risk factors contributing to disease progression in MN patients contracting remain unclear. This retrospective study included 656 consecutive with biopsy-proven primary who received treatment were regularly followed up for over six months. Logistic regression analyses conducted identify progression. Among the cohort, 555 (84.6%) contracted from November 11th, 2022, February...
Stem cells, such as adult stem cells or embryonic are the most important seed employed in tooth tissue engineering. Even though dental-derived a good source of for procedures, they not often used clinical applications because limited supply. Induced pluripotent (iPS) with their high proliferation and differentiation ability, now considered promising alternative. The objectives this study were to assess role iPS We real-time polymerase chain reaction confirm that mouse (miPS) can be induced...
Toll-like receptor 4 (TLR4) is a proinflammatory cascade initiator in poststroke inflammation. In this study, miR-1906, novel regulator of TLR4, was identified via silico analysis and microRNA profiling male adult mice its expression then quantitated the ischemic hemisphere. We found miR-1906 to be significantly brain enriched hemisphere even more drastically peri-infarct regions. Furthermore, vitro experiments demonstrated that, during oxygen–glucose deprivation, increased glial cells but...
Adipokine adiponectin (APN) has been recently reported to play a role in regulating bone mineral density (BMD). To explore the mechanism by which APN affects BMD, we investigated BMD and biomechanical strength properties of femur vertebra sham-operated (Sham) ovariectomized (OVX) knockout (KO) mice as compared their operated wild-type (WT) littermates. The results show that deficiency no effect on but induces increased ALP activity osteoclast cell number. While OVX indeed leads significant...
Abstract Background Isolation of mouse MSCs (mMSCs) with normal ploidy from bone marrow remains challenging. mMSCs isolated under 20% O 2 are frequently contaminated by overgrown hematopoietic cells, and could also be especially vulnerable to oxidative damage, resulting in chromosomal instability. Culture low oxygen or extracellular matrix (ECM) improves proliferation several species. We tested the hypothesis that culture combination ECM prepared embryonic fibroblast (MEF-ECM) used purify...
Cardiac hypertrophy is a major cause of morbidity and mortality worldwide. Transforming growth factor-β1 (TGF-β1) signaling has been considered as trigger causally contributing to pathological cardiac hypertrophy. Asiatic acid (AA) triterpenoid compound extracted from Centella asiatica exhibits variety pharmacological effects. In this study, we investigated the anti-hypertrophic effects mechanisms action AA in TGF-β1-stimulated hypertrophic response using cultured neonatal cardiomyocytes...
Abstract Background The aim of the present study was to investigate expression glucose-related protein 78 (GRP78) and heparanase (HPA) in oral squamous cell carcinoma (OSCC) their relationship with clinicopathological parameters potential implications for survival. Methods A total 46 patients OSCC 10 normal individuals were recruited study. GRP78 HPA determined lesion tissues using immunohistochemical analysis. correlation between assessed Spearman associations characteristics survival...
Examine the effects of dipeptidyl peptidase-4 (DPP4) inhibitor Sitagliptin on transforming growth factor-β1 (TGF-β1) signal transduction pathway in polycystic ovary syndrome (PCOS) rats with ovarian fibrosis.Thirty were divided randomly into PCOS model group, treatment group and blank control group. Dehydroepiandrosterone was administered to establish models. Then, phenotype recorded, serum sex hormone levels measured. The pathological structures rat ovaries observed. protein mRNA expression...
Our previous studies revealed that activation of mitochondrial ATP-sensitive potassium channels exerted protective effects on rotenone-treated rats and cultured cells. The aim the present study is to examine potential therapeutic iptakalim, an potassium-channel opener, diazoxide, a selective Parkinsonian symptoms in induced by rotenone. Rats were treated with rotenone (2.5 mg/kg s.c.) daily for 4 wk. This treatment caused depletion dopamine striatum substantia nigra. Behaviourally,...
Objectives We compared the efficacy, safety, and cost‐effectiveness of ultrasound‐guided percutaneous polidocanol injection ethanol for treatment benign cystic predominantly thyroid nodules. Methods A total 135 nodules treated by 136 were enrolled retrospectively in this study from May 2010 to March 2016. The followed after 1, 3, 6, 12 months. Nodule volumes, symptoms scores, cosmetic scores assessed before at follow‐up. therapeutic success rate, between groups also compared. Results No...
Tumour heterogeneity describes the coexistence of divergent tumour cell clones within tumours, which is often caused by underlying epigenetic changes. DNA methylation commonly regarded as a significant regulator that differs across cells and tissues. In this study, we comprehensively reviewed research progress on estimating heterogeneity. Bioinformatics-based analysis has revealed evolutionary relationships between breast cancer lines Further profiles in 33 cancer-related identified...