A5029212506- Silicon Carbide Semiconductor Technologies
- Semiconductor materials and devices
- Advanced biosensing and bioanalysis techniques
- Biosensors and Analytical Detection
- Semiconductor materials and interfaces
- CRISPR and Genetic Engineering
- Electromagnetic Compatibility and Noise Suppression
- Advancements in Semiconductor Devices and Circuit Design
- Integrated Circuits and Semiconductor Failure Analysis
- SARS-CoV-2 detection and testing
- Silicon and Solar Cell Technologies
- Advanced DC-DC Converters
- Plant Virus Research Studies
- Advanced Semiconductor Detectors and Materials
- Copper Interconnects and Reliability
- MicroRNA in disease regulation
- GaN-based semiconductor devices and materials
- Radiation Effects in Electronics
- Bacteriophages and microbial interactions
- Supercapacitor Materials and Fabrication
- Anodic Oxide Films and Nanostructures
- Advancements in Battery Materials
- Nanopore and Nanochannel Transport Studies
- Nanoplatforms for cancer theranostics
- Electrostatic Discharge in Electronics
Institute of Microelectronics
2015-2025
Chinese Academy of Sciences
2015-2025
Changchun Institute of Applied Chemistry
2016-2025
University of Debrecen
2023-2025
State Key Laboratory of Electroanalytical Chemistry
2022-2025
Nanchang University
2025
Washington University in St. Louis
2024
Xinjiang Medical University
2024
Sichuan University
2023-2024
China Agricultural University
2024
Abstract Desirable biosensing assays need to be sensitive, specific, cost‐effective, instrument‐free, and versatile. Herein we report a new strategy termed CLIPON ( C RISPR L arge DNA assembly I nduced P regnancy strips for signal‐ ON detection) that can deliver these traits. integrates commercial pregnancy test strip (PTS) with four biological elements: the human chorionic gonadotropin (hCG), CRISPR‐Cas12a, crRNA c auliflower‐like l arge‐sized D NA assemblies (CLD). uses Cas12a/crRNA...
More recently, NCAPG2 has emerged as an intrinsically essential participant of the condensin II complex involved in process chromosome cohesion and stabilization mitosis, its position particular tumours is now being highlighted. Simultaneously, genetic properties hint that it might have enormous potential to interpret malignant progression tumors a broader perspective, is, pan-cancer. Yet, at present, this recognition remains merely superficial there lack more detailed studies explore...
Coronavirus diseases such as the coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome 2 (SARS-CoV-2), pose serious threats. Portable and accurate nucleic acid detection is still an urgent need to achieve on-site virus screening timely infection control. Herein, we have developed on-site, semiautomatic system, aiming at simultaneously overcoming shortcomings suffered various commercially available assays, low accuracy, poor portability, instrument...
Background Gastric cancer (GC) represents a malignancy with multi-factorial combination of genetic, environmental, and microbial factors. Targeting lysosomes presents significant potential in the treatment numerous diseases, while lysosome-related genetic markers for early GC detection have not yet been established, despite implementing this process by assembling artificial intelligence algorithms would greatly break through its value translational medicine, particularly immunotherapy....
The polymerase chain reaction and many isothermal amplifications are able to achieve super gene amplification. Unfortunately, most commonly-used transduction methods, such as dye staining Taqman-like probing, still suffer from shortcomings including false signals or difficult probe design, incompatible with multi-analysis. Here a universal rational detection strategy has been established by translating amplicons enzyme-free strand displacement circuits via three-way junction-based remote...
In this article, the single-event response of 1.2-kV silicon-carbide (SiC) power MOSFETs with varied buffer layer designs is investigated by 2-D numerical simulations. The structural parameters layers are compared and analyzed to understand transient after heavy ion strike related physical mechanisms comprehensively. Simulation results reveal that an optimized single structure can be acquired using a relatively thicker (T μm) moderate doping concentration (D cm <sup...
In this paper, a new online temperature measurement method for SiC power metal-oxide-semiconductor field-effect transistors (MOSFETs) is proposed that uses the linear relationship between drain-source current(Ids) and of electronic devices. The temperature-sensitive characteristics transfer characteristic curve these MOSFETs are studied. results show under different applied gate voltages, effects on change in Ids different; same voltage, current each device maintains good with temperature,...
Solid‐state nanopore is a promising single molecular detection technique, but largely limited by relatively low resolution to small‐size targets and laborious design of signaling probes. Here we establish universal, CRISPR/Cas‐Assisted Nanopore Operational Nexus (CANON), which can accurately transduce different targeting sources/species into DNA structural probes via “Signal‐ON” mode. Target recognition activates the cleavage activity Cas12a/crRNA system then completely digest blocker an...
Solid‐state nanopore is a promising single molecular detection technique, but largely limited by relatively low resolution to small‐size targets and laborious design of signaling probes. Here we establish universal, CRISPR/Cas‐Assisted Nanopore Operational Nexus (CANON), which can accurately transduce different targeting sources/species into DNA structural probes via “Signal‐ON” mode. Target recognition activates the cleavage activity Cas12a/crRNA system then completely digest blocker an...
Background: Globally, Acute Myocardial Infarction (AMI) is a common cause of heart failure (HF), which has been leading mortality resulting from non-communicable diseases. On the other hand, increasing evidence suggests that role energy production within mitochondria strongly links to development and progression diseases, while Cuproptosis, newly identified cell death mechanism, not yet comprehensively analyzed aspect cardiovascular medicine.Materials Methods: 8 transcriptome profiles...
SiC MOSFET integrated with Schottky barrier diode (SBD) can handle the reverse current during switching operation and reduce package cost. However, SBD weakens high-voltage-withstanding capability of MOSFET. In this article, a novel 4H-SiC trench mesa-sidewall (TMS-SBD) is proposed studied 2-D simulation. Compared locating on mesa (TM-SBD), TMS-SBD shows larger breakdown voltage (BV), lower electric field in gate oxide, better tradeoff between BV specific ON-resistance. The also same as that...
Isothermal amplification, such as loop-mediated nucleic acid isothermal amplification (LAMP), is a highly promising technique that could revolutionize portable or point-of-care gene detection. However, the commonly used readouts of these reactions have been limited to small number options real-time fluorescence and colorimetric paper strips, which suffer from practical difficulties in further integration quantitation, respectively. To enrich readout library provide more suitable for variety...
Isothermal amplifications have found their potentials in applications of portable nucleic acid diagnostics. However, there are still several certain deficiencies existing the current amplification methods, including high false-positive signals, limited range targets, difficult primer design, and so forth. Here, we report an effective solution via development dual hairpin ligation-induced isothermal (DHLA) consisting (1) formation a probe (DHP) based on sequence specific hybridization...
Recent advances have demonstrated the significant potential and advantages to repurpose existing point-of-care reactions/devices realize portable detection of nonoriginal targets, e.g., pathogen genes. However, pursuing this aim usually requires protein indicator–nucleic acid conjugation via a covalent bond, which may bring drawbacks such as high cost, complicated procedure, annoying component rebuilding. Herein, we developed conjugation-free, effective, universal platform called CRIs-gel...