A5020298122- COVID-19 Clinical Research Studies
- Colorectal Cancer Screening and Detection
- Gastric Cancer Management and Outcomes
- Long-Term Effects of COVID-19
- COVID-19 diagnosis using AI
- Radiomics and Machine Learning in Medical Imaging
- SARS-CoV-2 and COVID-19 Research
- Ferroptosis and cancer prognosis
- Gastrointestinal Bleeding Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Cardiac Valve Diseases and Treatments
- Thyroid Cancer Diagnosis and Treatment
- Mechanical Circulatory Support Devices
- Lung Cancer Diagnosis and Treatment
- Traditional Chinese Medicine Studies
- Cardiac Fibrosis and Remodeling
- Pancreatitis Pathology and Treatment
- COVID-19 and healthcare impacts
- Esophageal Cancer Research and Treatment
- RNA modifications and cancer
- Metabolism, Diabetes, and Cancer
- Cardiovascular Disease and Adiposity
- Cardiovascular Function and Risk Factors
- Biodiesel Production and Applications
- Phytochemistry and Bioactive Compounds
Shanxi Medical University
2020-2025
First Hospital of Shanxi Medical University
2020-2025
Wuhan University
2020-2024
Renmin Hospital of Wuhan University
2020-2024
Zhejiang Chinese Medical University
2022-2024
Union Hospital
2020-2024
Huazhong University of Science and Technology
2020-2024
Huazhong Agricultural University
2023-2024
First Affiliated Hospital of GuangXi Medical University
2023
Guangxi Medical University
2023
Background: Tumor microenvironment is essential for breast cancer progression and metastasis. Our study sets out to examine the stromal immune infiltration in progression, prognosis treatment. Materials Methods: This work provides an approach quantifying scores by using ESTIMATE algorithm based on gene expression matrix of patients TCGA database. We found differentially expressed genes (DEGs) through limma R package. Functional enrichments were accessed Gene Ontology (GO) analysis Kyoto...
Triple-negative breast cancer (TNBC) is defined as a highly aggressive type of which lacks specific biomarkers and drug targets. Damage-associated molecular pattern (DAMP)-induced immunogenic cell death (ICD) may influence the outcome immunotherapy for TNBC patients. This study aims to develop DAMPs gene signature classify patients further predict their prognosis outcome.We identified DAMPs-associated subtypes 330 TNBCs using K-means analysis. Differences in immune status, genomic...
Treatments for coronavirus disease 2019 (COVID-19) are limited by suboptimal efficacy. From January 30, 2020 to March 23, 2020, we conducted a non-randomised controlled trial, in which all adult patients with laboratory-confirmed COVID-19 were assigned three groups non-randomly and given supportive treatments: Group A, Lopinavir-Ritonavir; B, Huashi Baidu Formula (a Chinese medicineformula made the China Academy of Medical Sciences treat COVID-19, is now clinical trial period) C, Formula....
Objective The objective of this study was to assess whether the weight-adjusted-waist index(WWI) is associated with prevalence asthma and age when first onset appears in US adults. Methods For analysis we selected participants from National Health Nutrition Examination Survey(NHANES)database between 2001 2018. A dose-response curve calculated using logistic regression,subgroup analysis,and a curve. Results included 44480 people over 20,including 6061 reported asthma, increase 15% each unit...
Abstract Gastric cancer (GC) is one of the most common malignancies and its prognosis extremely poor. This study identifies a novel oncogene, microfibrillar-associated protein 2 (MFAP2) in GC. With integrative reanalysis transcriptomic data, we found MFAP2 as GC prognosis-related gene. And aberrant expression was explored samples. Subsequent experiments indicated that silencing exogenous could affect motility cells. The inhibition be rescued by another FAK activator, fibronectin. process...
White light endoscopy is the most pivotal tool for detecting early gastric neoplasms. Previous artificial intelligence (AI) systems were primarily unexplainable, affecting their clinical credibility and acceptability. We aimed to develop an explainable AI named ENDOANGEL-ED (explainable diagnosis) solve this problem. A total of 4482 images 296 videos with focal lesions from 3279 patients eight hospitals used training, validating, testing ENDOANGEL-ED. traditional sole deep learning (DL)...
Background: Globally, Acute Myocardial Infarction (AMI) is a common cause of heart failure (HF), which has been leading mortality resulting from non-communicable diseases. On the other hand, increasing evidence suggests that role energy production within mitochondria strongly links to development and progression diseases, while Cuproptosis, newly identified cell death mechanism, not yet comprehensively analyzed aspect cardiovascular medicine.Materials Methods: 8 transcriptome profiles...
Background The 2021 Global Burden of Disease (GBD) study shows a continuous increase in the burden chronic kidney disease due to diabetes mellitus type 2 (CKD-T2DM) from 1990 2021. This examines influence dietary risk factors across various populations and socioeconomic groups. Methods Utilizing GBD data, we analyzed age-standardized CKD-T2DM metrics—including mortality, disability-adjusted life years (DALY), rates (ASR)—stratified by age, gender, region. employs estimated annual percentage...
Background: Previous research suggested that Chinese Medicine (CM) Formula Huashibaidu granule might shorten the disease course in coronavirus 2019 (COVID-19) patients. This aimed to investigate early treatment effect of well-managed patients with mild COVID-19. Methods: An unblinded cluster-randomized clinical trial was conducted at Dongxihu FangCang hospital. Two cabins were randomly allocated a CM or control group, 204 COVID-19 participants each cabin. All received conventional over 7 day...
Prompt diagnosis of early gastric cancer (EGC) is crucial for improving patient survival. However, most previous computer-aided-diagnosis (CAD) systems did not concretize or explain diagnostic theories. We aimed to develop a logical anthropomorphic artificial intelligence (AI) system named ENDOANGEL-LA (logical anthropomorphic) EGCs under magnifying image enhanced endoscopy (M-IEE).We retrospectively collected data 692 patients and 1897 images from Renmin Hospital Wuhan University, Wuhan,...
Changes in gastric mucosa caused by Helicobacter pylori (H. pylori) infection affect the observation of early cancer under endoscopy. Although previous researches reported that computer-aided diagnosis (CAD) systems have great potential H. infection, their explainability remains a challenge.We aim to develop an explainable artificial intelligence system for diagnosing (EADHI) and giving diagnostic basis endoscopy.A case-control study.We retrospectively obtained 47,239 images from 1826...
Endoscopic reports are essential for the diagnosis and follow-up of gastrointestinal diseases. This study aimed to construct an intelligent system automatic photo documentation during esophagogastroduodenoscopy (EGD) test its utility in clinical practice.Seven convolutional neural networks trained tested using 210,198 images were integrated endoscopic image reporting (EAIRS). We performance through man-machine comparison at three levels: internal, external, prospective test. Between May 2021...
The COVID-19 is sweeping the world with deadly consequences. Its contagious nature and clinical similarity to other pneumonias make separating subjects contracted non-COVID-19 viral pneumonia a priority challenge. However, testing has been greatly limited by availability cost of existing methods, even in developed countries like US. Intrigued wide routine blood tests, we propose leverage them for using power machine learning. Two proven-robust learning model families, random forests (RFs)...
Bleeding risk factors for gastroesophageal varices (GEV) detected by endoscopy in cirrhotic patients determine the prophylactical treatment will undergo following 2 years. We propose a methodology measuring factors. create an artificial intelligence system (ENDOANGEL-GEV) containing six models to segment GEV and classify grades (grades 1-3) red color signs (RC, RC0-RC3) of varices. It also summarizes changes above results with region real time. ENDOANGEL-GEV is trained using 6034 images from...
Endocrine therapy is a systemic and has become the main treatment strategy for patients with estrogen receptor (ER)-positive breast cancer. However, tamoxifen resistance an insurmountable clinical challenge, underlying mechanisms are still poorly understood. In this study, we explored roles of CXC chemokine type 4 (CXCR4) in tamoxifen-treated cancer resistance. Based on Gene Expression Omnibus (GEO) database, high expression CXCR4 was found to be associated worse overall survival (hazard...
Objective To report the first case of a neonatal pneumonia with 2019-nCoV infection, and experience successfully diagnosis treatment in late pregnancy woman novel coronavirus (critical type) Xinyang city. Methods The 38 weeks singleton complicated type), infection were retrospectively analyzed. Results A single male was delivered at 38-week gestation his mother by cesarean section under third level protection operation room. The delivery diagnosed day 2 delivery. Dyspnea severe...