A5102718689- Gastrointestinal motility and disorders
- Diet and metabolism studies
- Coccidia and coccidiosis research
- Nanoplatforms for cancer theranostics
- Stress Responses and Cortisol
- Pathogenesis and Treatment of Hiccups
- Veterinary Oncology Research
- Animal Nutrition and Physiology
- Immune Response and Inflammation
- Advancements in Transdermal Drug Delivery
- Congenital gastrointestinal and neural anomalies
- Advanced Drug Delivery Systems
- Advanced Nanomaterials in Catalysis
- Adipose Tissue and Metabolism
- Cancer Cells and Metastasis
- Liver Disease Diagnosis and Treatment
- Thermoregulation and physiological responses
- Liver Disease and Transplantation
- Nanoparticle-Based Drug Delivery
- Biotin and Related Studies
- Infectious Encephalopathies and Encephalitis
- Respiratory and Cough-Related Research
- Pharmacological Receptor Mechanisms and Effects
- Peptidase Inhibition and Analysis
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
University of South China
2023
Nanjing Agricultural University
2022-2023
Wuhan University
2016-2022
Renmin Hospital of Wuhan University
2016-2022
Maduramicin ammonium (MAD) is one of the most frequently used anticoccidial agents in broiler chickens. However, high toxicity and low solubility MAD limit its clinical application. In this study, MAD-loaded nanostructured lipid carriers (MAD-NLCs) were prepared to overcome defects by using highly soluble (NLCs). The formulation was optimized via a three-level, three-factor Box-Behnken response surface method. Then, optimal MAD-NLCs evaluated according their hydrodynamic diameter (HD), zeta...
Bleeding risk factors for gastroesophageal varices (GEV) detected by endoscopy in cirrhotic patients determine the prophylactical treatment will undergo following 2 years. We propose a methodology measuring factors. create an artificial intelligence system (ENDOANGEL-GEV) containing six models to segment GEV and classify grades (grades 1-3) red color signs (RC, RC0-RC3) of varices. It also summarizes changes above results with region real time. ENDOANGEL-GEV is trained using 6034 images from...
Coccidiosis is a worldwide epidemic intestinal disease with high incidence, which causes huge economic losses. Halofuginone hydrobromide (HF) widely applied as an effective anticoccidial drug in the poultry industry. However, its therapeutic efficacy severely restrained due to toxic effects, poor aqueous solubility and low permeability. Nanotechnology can improve biological effect of drugs, thus, reduce administered doses effects. The objective this study was investigate preventive potential...
Background/Aims: Acute cholecystitis is common in gallbladder motility disorder. Interstitial cells of Cajal (ICCs) the are involved regulation motility. The aim this study was to explore change ICCs acute cholecystitis. Methods: Thirty adult guinea pigs were randomly divided into 3 groups: a sham-operated group (healthy controls) and 2 groups. animals subjected bile duct ligation then laparotomy cholecystectomy at 24 48 hours after surgery. Immunohistochemistry, immunohistofluorescence,...
Canine mammary tumors (CMT) can severely compromise the life quality of affected dogs through local recurrence, distant metastases and ultimately succumb to death. Recently, more attention has been given potential antimetastatic effect maduramicin (MAD) on breast cancer. However, its poor aqueous solubility toxicity normal tissues limit clinical application. Therefore, address drawbacks MAD enhance anticancer effects, MAD-loaded TPGS polymeric micelles (MAD-TPGS) were prepared by a thin-film...
Irritable bowel syndrome (IBS) is a common disease characterized by intestinal dysmotility, the mechanism of which remains elusive. We aim to determine whether high-affinity choline transporter 1 (CHT1), determinant cholinergic signaling capacity, modulates motility associated with stress-induced IBS.
Irritable bowel syndrome (IBS) is a common disease with hyperalgesia, the mechanisms of which remain elusive. The cholinergic system known to be involved in pain inhibitory pathways multiple diseases, and its involvement IBS unknown.We aimed determine whether high-affinity choline transporter CHT1, major determinant signaling capacity, regulating intestinal sensations associated stress-induced visceral pain.An rat model was established by chronic water avoidance stress (WAS). Colonic...
Background . Visceral hypersensitivity is a common feature of irritable bowel syndrome. Cholinergic system involves in the development visceral hypersensitivity, and high-affinity choline transporter (CHT1) crucial importance uptake system. However, involvement CHT1 remains unknown. The research aimed to study expression dorsal root ganglions (DRGs) role hypersensitivity. Methods Repetitive water avoidance stress (WAS) was used induce rats. Colorectal distension (CRD) determined, abdominal...