A5100423110- Meat and Animal Product Quality
- Probiotics and Fermented Foods
- Animal Nutrition and Physiology
- Neuroscience and Neuropharmacology Research
- Biochemical effects in animals
- Plant Reproductive Biology
- Plant Molecular Biology Research
- Antibiotics Pharmacokinetics and Efficacy
- Food Quality and Safety Studies
- Neurotransmitter Receptor Influence on Behavior
- Transcranial Magnetic Stimulation Studies
- Anesthesia and Neurotoxicity Research
- Biochemical Analysis and Sensing Techniques
- Receptor Mechanisms and Signaling
- Sirtuins and Resveratrol in Medicine
- Metabolomics and Mass Spectrometry Studies
- Circadian rhythm and melatonin
- Selenium in Biological Systems
- Nematode management and characterization studies
- Salmonella and Campylobacter epidemiology
- Bird parasitology and diseases
- Animal Behavior and Reproduction
- Protein Hydrolysis and Bioactive Peptides
- Insect and Pesticide Research
- Plant Disease Resistance and Genetics
Wuhan Academy of Agricultural Sciences
2017-2024
Beijing Academy of Agricultural and Forestry Sciences
2021-2024
Sichuan Academy of Agricultural Sciences
2024
Institute of Agro-Products Processing Science and Technology
2024
Army Medical University
2022-2023
Southwest Hospital
2022-2023
Guizhou University
2022
Xinjiang Academy of Agricultural and Reclamation Science
2022
Ministry of Agriculture and Rural Affairs
2022
Nanjing Agricultural University
2022
The eyes are highly susceptible to the oxidative stress induced by ultraviolet B (UVB, wavelength between 280 ∼ 320 nm), which could cause severe damage cornea. Fullerenols effective antioxidants alleviate UVB-induced injury, while their application for is still rare. In present study, we investigated protective performance and mechanism of fullerenols on cornea under UVB radiation in vivo vitro. synthesized exhibited broad-spectrum free radical scavenging properties (applicable both...
Poor therapeutic outcomes of antioxidants in ophthalmologic clinical applications, including glutathione during photoreceptor degeneration retinitis pigmentosa (RP), are caused by limited anti-oxidative capacity. In this study, fullerenols synthesized and proven to be highly efficient vitro radical scavengers. Fullerenol-based intravitreal injections significantly improve the flash electroretinogram light/dark transition tests performed for 28 days on rd1 mice, reduce thinning retinal outer...
The cuticle is the first barrier against bacterial trans-shell penetration. To evaluate quality among different colored eggshells, an efficient and reliable method proposed in this paper on basis of opacity theory. It shown that Spearman's rank correlation coefficients between reported reflectance ΔE*ab methods are all more than 0.90 measuring deposition for same breed eggs, indicating result measured by credible. In addition, validity also verified Escherichia coli penetration experiments...
Thigh meat from Cobb 500 broiler (Cobb) and Beijing-You chicken (BYC) at marketable age were compared to explore the impact of growth rate on quality. BYC had a higher water capacity, as well lower shear forces IMF content than Cobb, indicating that has significant influence Additionally, 144 upregulated 44 downregulated differential metabolites identified using gas chromatography mass spectroscopy (GC-MS) liquid spectrometer (LC-MS). Moreover, we found difference between dominant expression...
AZD7325 is a novel α2,3 -subtype-selective partial GABA-A-receptor modulator. This study investigated the pharmacodynamics of single oral doses 2 mg and 10 on central nervous system (CNS) compared with placebo lorazepam mg.This double-blind, randomized, four way crossover enrolled 16 healthy males administered two validated CNS test batteries to measure drug effects cognitive, neurophysiologic psychomotor function subjective feelings. The pharmacological selectivity was by plotting saccadic...
In this study, we compared the antibacterial effectivity of eggs six precocial and four altricial bird species using Escherichia coli, based on their eggshell traits. The ultrastructure was observed a scanning electron microscope (SEM). According to SEM results, from birds (chicken, turkey, quail, duck, ostrich, goose) had cuticle eggshells, while (pigeon, budgerigar, munia, canary) did not. environment/selection pressure may induce divergent evolution process in birds. E. coli experiment...
Background Echinococcus granulosus (E. granulosus), a causative agent of zoonotic diseases, is widely prevalent across most regions and primarily affects vital organs such as the liver lungs. The parasite secretes immunomodulatory substances, its protoscolex proteins (PSCs) have been identified potential diagnostic antigens vaccine candidates. Although transcriptomics metabolomics approaches employed to investigate echinococcosis, impact PSCs on functionality host immune cells expression...
Fortifying yogurt with blueberries, potatoes, and Perilla seed oil (PO) can enhance the yogurt's nutritional health-promoting effects. This study aimed to evaluate development of volatile compounds, physicochemical quality, amino acids, shelf life flavored supplemented PO. Results revealed that adding PO changed flavor composition free acid content. The essential increased 0.346 times by Moreover, addition significant differences (P < 0.05) in sensory scores, fat, acidity, color, syneresis,...
Unique metabolites contribute to the performance of meat flavor and potential function. In this study, UHPLC-Q Exactive HF-X-based metabolomics multivariate analysis were applied explore characteristic in breast Beijing-You chicken (BYC) aged 150, 300, 450 days (D150, D300, D450). Based on criteria variable importance projection (VIP) > 1
Genetic control of parthenocarpy, a desirable trait in edible fruit with hard seeds, has been extensively studied. However, the molecular mechanism parthenocarpic development eggplant (Solanum melongena L.) is still unclear. To provide insights into transcriptomic profiles natural (PP05) and two non-parthenocarpic (PnP05 GnP05) lines were analyzed using RNA-sequencing (RNA-seq) technology. These sequences assembled 38925 unigenes, which 22683 had an annotated function 3419 predicted as novel...
AZD6280 is a novel γ-aminobutyric acid A receptor modulator with higher in vitro efficacy at the α2,3 subtypes as compared to α1 and α5 subtypes. This study pharmacodynamic effects of single oral dose 10 mg 40 on central nervous system 2 lorazepam.Sixteen healthy males were enrolled into double-blind, randomized, 4-way crossover study. Two validated test batteries, Neurocart CogState, administered measure drug cognition, neurophysiologic function, psychomotor subjective feelings. Statistical...
Abstract Introduction The repetitive transcranial magnetic stimulation (rTMS) has clinically wide application prospect of psychiatry and neuroscience, for its painless, noninvasive, high efficiency. So far, rTMS been used in the treatment Alzheimer's disease (AD) but underlying mechanism is not clear. Methods Results APP/PS1 mice at 3‐month‐old were treated by 5 Hz high‐frequency (HF) two weeks. After treatment, AD‐like cognitive impairments investigated subsequently, molecular mechanisms...
Eggplant (Solanum melongena L.), which belongs to the Solanaceae family, is an important vegetable crop. However, its production severely threatened by root-knot nematodes (RKNs) in many countries. Solanum torvum, a wild relative of eggplant, employed worldwide as rootstock for eggplant cultivation due resistance soil-borne diseases such RKNs. In this study, identify RKN defense mechanisms, transcriptomic profiles and torvum were compared. A total 5360 differentially expressed genes (DEGs)...
Maduramicin ammonium (MAD) is one of the most frequently used anticoccidial agents in broiler chickens. However, high toxicity and low solubility MAD limit its clinical application. In this study, MAD-loaded nanostructured lipid carriers (MAD-NLCs) were prepared to overcome defects by using highly soluble (NLCs). The formulation was optimized via a three-level, three-factor Box-Behnken response surface method. Then, optimal MAD-NLCs evaluated according their hydrodynamic diameter (HD), zeta...
Chicken age contributes to the meat characteristics; however, knowledge regarding pathways and proteins associated with quality muscle development are still scarce, especially in chicken thigh meat. Hence, objective of this study was elucidate intricate relationship between these traits by liquid chromatography mass spectrometry at three different ages. A total 341 differential expressed (DEPs) were screened out (fold change ≥ 1.50 or ≤0.67 p < 0.05) among 45 samples (15 per age) Beijing-You...
Various α(2,3) subtype selective partial GABA-A agonists are in development to treat anxiety disorders. These compounds expected be anxiolytic with fewer undesirable side effects, compared nonselective like benzodiazepines. Several and have been examined healthy volunteers, using a battery addressing different brain domains. Data from five placebo-controlled double-blind studies were pooled. Lorazepam 2 mg was the comparator three studies. Three α(2,3)-selective GABAA (i.e., TPA023, TPACMP2,...