A5101902701- Acute Myeloid Leukemia Research
- RNA modifications and cancer
- MicroRNA in disease regulation
- Lung Cancer Treatments and Mutations
- Esophageal Cancer Research and Treatment
- RNA Interference and Gene Delivery
- Liver physiology and pathology
- Neuroblastoma Research and Treatments
- Cancer-related Molecular Pathways
- Advanced biosensing and bioanalysis techniques
- Traditional Chinese Medicine Analysis
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Signaling Pathways in Disease
- Cancer-related gene regulation
- Molecular Biology Techniques and Applications
- Colorectal Cancer Treatments and Studies
- Lung Cancer Research Studies
- Lymphoma Diagnosis and Treatment
- Cancer Research and Treatments
- Cancer-related molecular mechanisms research
- Eosinophilic Disorders and Syndromes
- Endoplasmic Reticulum Stress and Disease
- Neurological Disorders and Treatments
- Nuclear Receptors and Signaling
- Liver Disease Diagnosis and Treatment
Fujian University of Traditional Chinese Medicine
2019-2025
Chongqing Medical University
2005-2024
First Affiliated Hospital of Soochow University
2019-2024
Fudan University
2012-2024
Fudan University Shanghai Cancer Center
2024
Shanghai Medical College of Fudan University
2024
Soochow University
2019-2024
Second Affiliated Hospital of Chongqing Medical University
2005-2024
Moffitt Cancer Center
2020-2024
Dalian Medical University
2005-2024
Abstract The tumor microenvironment (TME) is the ecosystem surrounding a tumor, which usually consists of nontumoral cells or components, and molecules they produce release. frequent continuous interplay between TME strongly affects development, disease progression, metastasis, responses to therapeutic interventions. As hub potential targets, has gained appreciable momentum in cancer research. Here we systematically review progress targeting as strategy develop novel antitumor drugs from...
Abstract Purpose: Signal transducer and activator of transcription 3 (Stat3) is constitutively activated in a variety cancers it common feature prostate cancer. Thus, Stat3 represents promising molecular target for tumor therapy. We applied DNA vector–based Stat3-specific RNA interference approach to block signaling evaluate the biological consequences down-modulation on growth using mouse model. Experimental Design: To investigate therapeutic potential blocking cancer cells, three small...
Abstract Acute kidney injury ( AKI ) is a common and severe clinical condition with high morbidity mortality. Ischaemia‐reperfusion (I/R) remains the major cause of in clinic. Ferroptosis recently discovered form programmed cell death PCD that characterized by iron‐dependent accumulation reactive oxygen species ROS ). Compelling evidence has shown renal tubular involves ferroptosis, although underlying mechanisms remain unclear. Augmenter liver regeneration ALR widely distributed...
Abstract Background and Aim Hydronidone (HDD) is a novel pirfenidone derivative developed initially to reduce hepatotoxicity. Our previous studies in animals humans have demonstrated that HDD treatment effectively attenuates liver fibrosis, yet the underlying mechanism remains unclear. This study aimed investigate whether exerts its anti‐fibrotic effect by inducing apoptosis activated hepatic stellate cells (aHSCs) through endoplasmic reticulum stress (ERS)‐associated mitochondrial apoptotic...
ZNF750 is one novel significantly mutated gene identified in esophageal squamous cell carcinoma (ESCC) using next-generation sequencing. However, its clinically relevant and potential mechanisms have remained elusive. Using genomic sequencing of 612 ESCC patients, we analyzed the associations mutations with clinicopathologic features prognostic value. We further investigated function underlying mechanism angiogenesis. The results showed mutations/deletions are associated malignant...
Exposure to ambient PM2.5 is associated with neurodegenerative disorders, in which microglia activation plays a critical role. Thus far, the underlying mechanisms for PM2.5-induced have not been well elucidated. In this study, human microglial cell line (HMC3) was used as vitro model examine inflammatory effect (hall marker of activation) and regulatory pathways. The expression mediators including interleukin-6 (IL-6) cyclooxygenase-2 (COX-2) brain derived neurotrophic factor (BDNF) were...
Stroke is a debilitating condition with high morbidity, disability, and mortality that significantly affects the quality of life patients. In China, WenYang FuYuan recipe widely used to treat ischemic stroke. However, underlying mechanism remains unknown, so exploring potential action this formula great practical significance for stroke treatment. This study employed network pharmacology, molecular docking, in vivo experiments clarify active ingredients, targets, mechanisms cerebral...
Context Qing-Xin-Jie-Yu Granule (QXJYG) has shown promise in the treatment of myocardial infarction. However, mechanism action QXJYG underlying its anti-inflammation remain unknown.
Paeoniflorin exhibits anticancer, anti-inflammatory and antioxidation effects, as well specific pharmacological effects on smooth muscle the immune, cardiovascular central nervous systems. The present study aimed to investigate anticancer of paeoniflorin pancreatic cancer cells elucidate mechanisms by which these occur. In study, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide lactate dehydrogenase assays were performed assess cell viability cytotoxicity BXPC-3 human cells,...
Nucleophosmin (NPM1) is an abundant and ubiquitously expressed phosphoprotein that known to influence solid tumors progression.However, little about the role of NPM1 in leukemia.Here, we knocked down expression by RNA interference investigate leukemic cells proliferation apoptosis.The vector pNPM1-shRNA was constructed transfected into human K562 cell line.The levels mRNA protein were detected quantitative real-time PCR Western blot, respectively.Cells potential vitro assessed methyl...
To retrospectively analyze KRAS and BRAF gene mutation features in Chinese colorectal cancer (CRC) their clinicopathologic relationship.557 cases were collected, including 325 colon 232 rectal cancer. PCR amplification DNA sequencing used to detect mutations exon 2 of 15 mutation.(1) was found 40.4% (225/557) The most common locations codon 12(79.1%, 178/225) 13 (20.4%, 46/225). types GGT > GAT (G12D) (37.8%, 85/225), GTT(G12V) (20.0%, 45/225) 12 GGC GAC (G13D) (19.6%, 44/225). These three...
// Qin Zou 1 , Shi Tan 2 Zailin Yang 3 Juan Wang 4 Jingrong Xian Shuaishuai Zhang Hongjun Jin Liyuan Lu Ling Key Laboratory of Medical Diagnostics Designated by the Ministry Education, College Medicine, Chongqing University, Chongqing, China Department Clinical Laboratory, Health Center for Women and Children, Hematology, Southwest Hospital, Third Military Children’s Diagnosis Center, Qilu Hospital Shandong Jinan, Correspondence to: Zhang, email: lingzhang@cqmu.edu.cn Keywords:...
The use of 5-fluorouracil (5-FU) has been proven benefits, but it also adverse events in colorectal cancer (CRC) chemotherapy. In this study, we explored the mechanism 5-FU resistance by bioinformatics analysis NCBI public dataset series GSE81005. Fifteen hub genes were screened out 582 different expressed genes. Modules protein-protein interaction networks gathered to TOP2 α showed a decrease HCT-8 cells an increase 5-FU-resistant HCT-8/5-FU with exposure. Downregulation siRNA or miR-494...
Background: Amivantamab (JNJ-372) and mobocertinib (TAK-788) have been reported to favorable therapeutic effect for non-small cell lung cancer (NSCLC) patients with epidermal growth factor receptor (EGFR) exon 20 insertion (ex20ins) mutations. Thus, accurate detection of EGFR ex20ins mutations is crucial subsequent individualized therapy. The aim this study was compare the two common methods next generation sequencing (NGS) amplification refractory mutation system polymerase chain reaction...
We describe a case of recurrent and metastatic radioactive iodine-refractory differentiated thyroid cancer (RAIR-DTC) treated with anlotinib in this report. The patient was randomized to placebo initially, after disease progressed at C8 (C is the treatment cycle), referred open label therapy anlotinib, 12 mg p.o. daily 2-week on/1-week off regimen. Partial response achieved C2 treatment. To date, over 37 months progression-free survival (PFS) has been achieved. Adverse effects were tolerable...
Studies comparing the prognostic role of RUNX1 mutations (RUNX1mut) in acute myeloid leukemia (AML) and leukemia-with myelodysplasia-related changes (AML-MRC) are limited. Our study examines genetic profile 118 RUNX1mut AML patients including 57 with 61 AML-MRC 100 AML, NOS wild type (RUNX1wt). Results revealed that had shorter median overall survival (OS) (11 ± 3.3 months) when compared to (19 7.1 RUNX1wt (not reached) (p = .001). The most common concurrent observed were DNMT3A, SRSF2,...