Abstract Purpose: Signal transducer and activator of transcription 3 (Stat3) is constitutively activated in a variety cancers it common feature prostate cancer. Thus, Stat3 represents promising molecular target for tumor therapy. We applied DNA vector–based Stat3-specific RNA interference approach to block signaling evaluate the biological consequences down-modulation on growth using mouse model. Experimental Design: To investigate therapeutic potential blocking cancer cells, three small...

Bacterial cellulose (BC) is a natural biomaterial with unique properties suitable for tissue engineering applications, but it has not yet been used preparing nerve conduits to repair peripheral injuries. The objectives of this study were prepare and characterize the Kampuchea-synthesized bacterial (KBC) further evaluate biocompatibility KBC cells tissues in vitro vivo. membranes composed interwoven ribbons about 20–100 nm width, had high purity same crystallinity as that Iα. results from...

Nonalcoholic fatty liver disease (NAFLD) induced by obesity is a grave threat to human health. Phytic acid (PA) natural compound found in high-fiber diets, such as soybeans. This study investigated the effects and mechanisms of PA on obesity, hepatic lipid metabolism, gut-liver axis homeostasis high-fat diet (HFD)-fed mice. was observed significantly inhibit alleviate steatosis improved HFD-induced inflammation, oxidative stress fibrosis. Moreover, colonic gut barrier damage systemic...

Alterations in lipid metabolic pathways constitute a pivotal characteristic of Steroid-Sensitive Nephrotic Syndrome (SSNS). Despite the significance, there has been scant exploration into influence polyunsaturated fatty acids (PUFAs) on syndrome (MetS) children with SSNS. This study endeavors to elucidate association between PUFAs and MetS this specific pediatric population. enrolled total 185 aged 0–7 years SSNS May 2023 2024. Based international guidelines for MetS, patients were...

Abstract: Zein-based nano/microparticles have been demonstrated to be promising carrier systems for both the food industry and biomedical applications. However, fabrication of size-controlled zein particles has a challenging issue. In this study, modified anti-solvent precipitation method was developed, effects various factors, such as mixing method, solvent/anti-solvent ratio, temperature, concentrations presence sodium caseinate (SC) on properties were investigated. Evidence is presented...

Summary This paper introduced a kind of binary composite particle constructed by zein particles and grape seed proanthocyanidins (PAs). The physicochemical performance the zein/PAs complex colloidal (ZPAPs) was systematically evaluated. Fourier transform infrared spectroscopy (FTIR) showed that interactions between PAs were mainly hydrogen bonds hydrophobic interactions. three‐phase contact angle (θo/w) around 120.7 ± 0.7°, it decreased to 100.8 0.6° after addition PAs, indicating ZPAPs more...

Abstract Background Formative assessment (FA) is becoming increasingly common in higher education, although the teaching practice of student-centred FA medical curricula still very limited. In addition, there a lack theoretical and pedagogical studies observing from students’ perspectives. The aim this study to explore understand ways improve FA, provide practical framework for future construction an index system curricula. Methods This used questionnaire data undergraduate students clinical...

Zein-based carriers are a promising delivery system for biomedical applications. However, few studies involve systematic investigation on their in vivo biocompatibility and immunogenicity.The objective of this study was to identify the immunogenicity, type immune response, systemic recall response zein nanoparticles administrated via different routes mice.Female Balb/c mice were selected as animal model paper. The effect particle size, dose inoculation immunogenicity systematically explored....

Synthetic single-chain bolalipids with symmetrical headgroups have shown potential in various pharmaceutical applications, such as the stabilization of liposome bilayers. Despite their amphiphilic character, synthetic not yet been investigated for suitability solubilizing agents poorly soluble drug compounds. In this study, three increasing alkyl chain lengths (C22, C24 and C26) were investigated. All able to achieve an increased solubility model drug, mefenamic acid, by approximately 180% a...

Cartilage Regeneration In article number 2304088, Feng Li, Dong Sun, and co-workers developed the cell delivery microrobot by a protocol combining decellularization magnetization. It is derived from decellularized natural porcine cartilage extracellular matrix, which has biomechanical environment to that of human can efficiently load functional cells while maintaining high mobility. preclinical tests, authors demonstrate therapeutical effects it for regeneration.

Magnetic microrobot swarms have broad application prospects in human-targeted therapy. However, the automated assembly and actuation of functional large-volume is a challenging topic. Chlorella with self-fluorescence biodegradability used this paper as template to prepare magnetic Chlorella-based microrobots through magnetron sputtering. The are realized using tweezer system robust field. Experimental results indicate that (MCS) possess excellent degradation capability mobility, enabling...

In this study, a novel conjugate consisting of glycol chitosan (GCS) and ethylene diamine tetraacetic acid (EDTA) was synthesized characterized in terms conjugation heavy metal ion chelating capacity. Moreover, its potential application as metalloenzyme inhibitor evaluated with three thymopoietin oligopeptides the presence leucine aminopeptidase. The results from FTIR NMR spectra revealed that covalent attachment EDTA to GCS achieved by formation amide bonds between carboxylic group amino...

Previous experience has shown that transit responsive signal control ability to reduce delay of buses in urban areas when compared traditional fixed-time at arterial progression. However, most these experiences have focused primarily on the impact or per person. This paper describes development and evaluation passive priority with phase overlapped (TPPTPO) explicitly considers impacts private automobiles. method is unique two ways. First, this interference caused general traffic by vehicles...

Reactors are widely used in power systems because of their important functions.Its series connection with reactors the places where outlet breakers can increase short-circuit impedance and limit short circuits' current.And its parallel connections capacitors wave filters harmonics electrified wire nets.And running voltages be adjusted by adjusting paralleling reactors.The passage briefly introduced developing history, trengths weakness six kinds including cement hollow reactor ,oil immersed...

Current active transit signal priority (TSP) methods are based on real-time detection of information, often with the green extension and early to make bus pass through intersection as soon possible. In this paper, according domestic environment, applying in artery coordination system, using related principle parameter, can not only guarantee execute priority, but also impact system minimum. Moreover, should consider irregular phase, such overlapping phase ensure traffic flow smoothly...

We chose cast and extrude magnesium alloy AZ61 as materials studied the influences of temperature, humidity, pressure NaCl atmosphere on corrosion products mechanism by means SEM, EDS XRD. we could indicate corr osion rate extruded is faster than that magnesium. Both th e rearrange second ph ase smaller grain size, which owing to extrusion process, change morphologies products.