A5074713437- interferon and immune responses
- Immune Cell Function and Interaction
- Immune cells in cancer
- Traumatic Brain Injury and Neurovascular Disturbances
- Cytokine Signaling Pathways and Interactions
- Immune Response and Inflammation
- Proteins in Food Systems
- Cholesterol and Lipid Metabolism
- NF-κB Signaling Pathways
- Pickering emulsions and particle stabilization
- Metabolomics and Mass Spectrometry Studies
- Neonatal Respiratory Health Research
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
University of Chinese Academy of Sciences
2019-2022
Center for Excellence in Molecular Cell Science
2019-2022
Jilin University
2017
The combination use of TGF-β, M-CSF, and IL-6 represents a promising therapy to repair traumatic brain injury.
Abstract: Zein-based nano/microparticles have been demonstrated to be promising carrier systems for both the food industry and biomedical applications. However, fabrication of size-controlled zein particles has a challenging issue. In this study, modified anti-solvent precipitation method was developed, effects various factors, such as mixing method, solvent/anti-solvent ratio, temperature, concentrations presence sodium caseinate (SC) on properties were investigated. Evidence is presented...
Interferon regulatory factor 3 (IRF3)-induced type I interferon (I-IFN) production plays key roles in both antiviral and autoimmune responses. IRF3 phosphorylation, dimerization, nuclear localization are needed for its activation function, but the precise mechanisms remain to be explored. Here, we show that serine/threonine kinase AKT2 interacts with phosphorylates it on Thr207, thereby attenuating translocation a 14-3-3ε-dependent manner reducing I-IFN production. We further find expression...
Significance Improving cytotoxicity, proliferation, and infiltration ability of CD8 + T cells is critical in cell immunotherapies against tumors. This study has identified LRCH1 as a negative regulator LAT-mediated TCR signal transduction, inhibits LAT signalosome formation facilitates the endocytosis on plasma membrane. LRCH1-deficient are more proliferative effective at pathogen control tumor elimination. Importantly, CRISPR-Cas9–mediated knockout human also increases IFN-γ production,...