A5046819849- Cancer-related molecular mechanisms research
- Liver Disease Diagnosis and Treatment
- Bone Metabolism and Diseases
- MicroRNA in disease regulation
- Cell Adhesion Molecules Research
- Cancer Cells and Metastasis
- Gastric Cancer Management and Outcomes
- Genomics, phytochemicals, and oxidative stress
- PI3K/AKT/mTOR signaling in cancer
- Advanced Computational Techniques and Applications
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cancer therapeutics and mechanisms
- Inflammatory mediators and NSAID effects
- Colorectal Cancer Treatments and Studies
- Flavonoids in Medical Research
- Gut microbiota and health
- Lipid metabolism and disorders
- Monoclonal and Polyclonal Antibodies Research
- Immune Response and Inflammation
- Cardiovascular and exercise physiology
- Endodontics and Root Canal Treatments
- Bone and Dental Protein Studies
- Nuclear Receptors and Signaling
- Cardiac Fibrosis and Remodeling
- Angiogenesis and VEGF in Cancer
Fujian University of Traditional Chinese Medicine
2013-2025
Shanghai Tenth People's Hospital
2023-2025
Tongji University
2024-2025
State Key Laboratory of Pollution Control and Resource Reuse
2025
Nanjing University
2025
Changsha Central Hospital
2019-2025
Shenyang Agricultural University
2025
Ministry of Agriculture and Rural Affairs
2025
Soil and Fertilizer Institute of Hunan Province
2025
Central South University
2024
Gut-liver axis is increasingly recognized to be involved in the pathogenesis and progression of non-alcoholic fatty liver disease (NAFLD). The gut microbiota intestinal permeability have been demonstrated key players gut-liver cross talk NAFLD. Geniposide chlorogenic acid (GC) combination derived from a traditional Chinese medicine, Qushi Huayu Decoction (QHD), which has used clinic for NAFLD treatment decades China validated multiple animal models GC previously treat via modulation on...
MicroRNAs are known to play an important role in modulating gene expression various diseases including cancers and cardiovascular disorders, but only a few of them associated with the pathology aflatoxin B1 (AFB1), potent mycotoxin. Here, we discovered novel regulatory network between AFB1, miR-33a β-catenin human carcinoma cells. The level was up-regulated hepatocellular (HCC) cells treated while same causing decrease when at their IC50 values. miR-33a, specifically miR-33a-5p, demonstrated...
NPS6 is one of the nonribosomal peptide synthetase (NRPS) family members. The roles in ascomycetes are well known, but its Fusarium oxysporum unidentified. We investigated function growth, morphology, stress sensitivity, allelochemical secretion, and pathogenesis F. (FoNPS6). partial deletion FoNPS6 orthologs (ΔFON-NPS6) resulted hypersensitivity to H2O2 KO2, iron depletion, reduced virulence. Full virulence was restored by complementation. ΔFON-NPS6 not only inhibited spore formation also...
Carbohydrate kinases serve an oncogenic role in several types of cancer; however, the function FGGY carbohydrate kinase domain containing (FGGY) colorectal cancer (CRC) remains unknown. The present study investigated and possible molecular mechanisms CRC. results showed that elevated levels mRNA protein were observed CRC tissues, a higher expression was associated with advanced N stage reduced overall survival time patients Silencing inhibited viability cells by inducing cell cycle arrest...
N-glycosylation of immunoglobulin G (IgG) at asparigine residue 297 plays a critical role in antibody stability and immune cell-mediated Fc effector function. Current understanding pertaining to glycosylation is based on studies with IgGs that are either fully glycosylated [both heavy chain (HC) glycosylated] or aglycosylated (neither HC glycosylated). No study has been reported the properties hemi-glycosylated IgGs, antibodies asymmetrical region such one other aglycosylated. We report here...
Tumor necrosis factor–α (TNF-α) is involved in various inflammatory processes, including periodontitis. Although the influences of TNF-α on periodontal ligament fibroblasts and osteoblasts have been widely documented, its effects cementoblasts, cells responsible for cementum production, remain largely unknown. In this study, we found that suppressed mineralization ability cementoblasts by inhibiting differentiation inducing apoptosis. Various signaling pathways, such as p53, PP2A C , p38,...
Microsoft SQL Server 2008 adds built-in support for 2-dimensional spatial data types both planar and geodetic geometries to address the increasing demands managing location-aware data. also indexing capabilities that, together with necessary plan selections done by query optimizer, provide efficient processing of queries. This paper will present an overview implementation in outline how is implemented cost-based optimizer chooses among different plans.
OBJECTIVE: This prospective randomized study evaluated the efficacy and patient tolerance of dexmedetomidine compared with midazolam for sedation in postoperative patients undergoing flexible bronchoscopy. METHODS: A total 198 were to receive ( n = 99) or produce conscious Peripheral oxygen saturation, heart rate systolic diastolic arterial pressures recorded before, during after procedure. Patient was using various visual analogue scales. RESULTS: The mean lowest peripheral saturation...
Background: Qingda granules (QDG) exhibit antihypertension and multiple-target-organ protection. However, the therapeutic potential of QDG on hypertensive renal injury remains unknown. Therefore, main objective current study is to explore effects underlying mechanisms treatment in angiotensin (Ang) II-infused mice. Methods results: Mice were infused with Ang II (500 ng/kg/min) or saline for 4 weeks subcutaneously implanted osmotic pumps. After infusion, mice + group intragastrically...
Context Ulcerative colitis has been clinically treated with Qing Hua Chang Yin (QHCY), a traditional Chinese medicine formula. However, its precise mechanisms in mitigating chronic are largely uncharted.
Scutellaria barbata D. Don (SB) has long been used as a major component in numerous Chinese medical formulas to clinically treat various types of cancer. Previously, we reported that the extracts SB were able suppress colon cancer growth vivo and vitro, possibly by inducing cell apoptosis inhibiting proliferation tumor angiogenesis. However, anticancer mechanisms its bioactive ingredients remain largely unclear. In present study, using three human lines SW620, HT-29 HCT-8, antitumor effect...
Scutellaria baicalensis Georgi is an extensively used medicinal herb for the treatment of hypertension in traditional Chinese medicine. Baicalin, important flavonoid extracts, which exhibits therapeutic effects on anti-hypertension, but its underlying mechanisms remain to be further explored. Therefore, we investigated and molecular Baicalin anti-hypertension. In vivo studies revealed that significantly attenuated elevation blood pressure, pulse propagation thickening abdominal aortic wall...
Abstract Objective: The aim of this study was to explore the effects Babao dan (BBD), a traditional Chinese medicine, on gastric cancer (GC) progression in vivo . Materials and Methods: A subcutaneous xenograft mouse model GC established using MGC80-3 cells. terminal deoxynucleotidyl transferase-mediated dUTP: 2’-deoxyuridine 5’-triphosphate -biotin nick-end labeling method adopted detect cell apoptosis expression levels proteins associated with proliferation, apoptosis, angiogenesis were...
ATP-binding-cassette family membrane proteins play an important role in multidrug resistance. In this study, we investigated BIRB796, orally active inhibitor of p38 mitogen-activated protein kinase, reversed MDR induced by ABCB1, ABCG2 and ABCC1. Our results showed that BIRB796 could reverse ABCB1-mediated both the drug selected transfected ABCB1-overexpressing cell models, but did not enhance efficacy substrate-chemotherapeutical agents ABCC1 or overexpression cells their parental sensitive...
To assess the effects of perioperative comprehensive supportive care interventions on outcome Chinese esophageal cancer patients in a prospective study.60 with primary carcinoma were randomized into an intervention group (IG, n=31) and control (CG, n=29). The version symptom checklist-90 (SCL-90) was adopted to their psychological status. interventions, including health education, support, stress management, coping strategies behavior training, carried out 3 phases (preoperative,...