A5101876093- Glutathione Transferases and Polymorphisms
- Biochemical effects in animals
- Acute Ischemic Stroke Management
- Aldose Reductase and Taurine
- Venous Thromboembolism Diagnosis and Management
- Effects of Radiation Exposure
- Hormonal Regulation and Hypertension
- Antiplatelet Therapy and Cardiovascular Diseases
- Lung Cancer Diagnosis and Treatment
- Cancer Cells and Metastasis
- Cerebrovascular and Carotid Artery Diseases
- Cytokine Signaling Pathways and Interactions
- Neurological Disease Mechanisms and Treatments
- Antioxidant Activity and Oxidative Stress
- Cardiovascular and Diving-Related Complications
- Neuroinflammation and Neurodegeneration Mechanisms
- Cancer Mechanisms and Therapy
- Gastric Cancer Management and Outcomes
- Renal Diseases and Glomerulopathies
- Dermatology and Skin Diseases
- Stroke Rehabilitation and Recovery
- Clinical Nutrition and Gastroenterology
- Liver Disease Diagnosis and Treatment
- Enhanced Recovery After Surgery
- Epigenetics and DNA Methylation
China National Nuclear Corporation
2020-2025
Chengdu Medical College
2020-2025
Xinjiang Medical University
2013-2024
International Platform of Registered Systematic Review and Meta-analysis Protocols
2024
Weatherford College
2024
Sun Yat-sen University
2018-2023
Hunan Academy of Traditional Chinese Medicine
2022-2023
Shanghai University of Traditional Chinese Medicine
2021-2022
The First Affiliated Hospital, Sun Yat-sen University
2018-2021
Nantong University
2021
Background Secreted protein acidic and rich in cysteine (SPARC), a calcium-binding matricellular glycoprotein, is implicated the progression of many cancers. In this study, we investigated expression function SPARC ovarian cancer. Methods cDNA microarray analysis was performed to compare gene profiles highly invasive low subclones derived from SKOV3 human cancer cell line. Immunohistochemistry (IHC) staining investigate total 140 tissue specimens. functional assays, effects knockdown on...
Safe and effective prophylactic therapies for radiation-induced dermatitis (RID) remain an unmet need.To determine if epigallocatechin-3-gallate (EGCG) solution reduces the incidence of RID in patients undergoing radiotherapy after breast cancer surgery.This phase 2 double-blind, placebo-controlled randomized clinical trial enrolled 180 with receiving postoperative at Shandong Cancer Hospital Institute Shandong, China, between November 2014 June 2019. Data analysis was performed from...
Cancer cells frequently use fructose as an alternative energy and carbon source, to fuel glycolysis support the synthesis of various biomacromolecules.Glut5 is only fructose-specific transporter, which lacks ability transport other carbohydrates such glucose galactose.Interplay between inflammatory factors cancer renders tissue environment a predisposing condition for development.Nevertheless, how coordinate with metabolism facilitate tumor growth remains largely elusive.Here we show that...
Radiation-induced skin injury (RISI) is a frequent complication of radiotherapy, yet current preventive strategies exhibit suboptimal efficacy. Our previous publications have consistently demonstrated the effectiveness biomaterials and hydrogels in preventing RISI. Based on comprehensive literature reviews, we speculate that NLRP3 overexpression plays central role development Therefore, designing DNAzyme (DZ)-hydrogels with targeted inhibition crucial for RISI.To achieve this, designed...
Insulin resistance was reported to increase the risk of ischemic stroke, which can be assessed by triglyceride glucose (TyG) index. However, it remains unclear whether TyG index influences platelet reactivity during treatment patients.Ischemic stroke patients receiving dual antiplatelet therapy (DAPT) within 48 h onset were consecutively included. The calculated as ln (fasting [mg/dL] × fasting [mg/dL]/2). top quartile defined insulin resistance. thromboelastography. inhibition rate induced...
To observe the effects of neural stem cells (NSCs) transplantation in rats' striatum and subventricular zone (SVZ) rat models focal cerebral ischemia reperfusion. Hippocampus was extracted from fetal rats with 14 days gestation. Suspension culture used to isolate rat's NSCs. A reperfusion model made on left side brain through occlusion middle artery. Neurological signs were assessed by Zea Longa's five-grade scale, scores 1, 2, 3 determine successful establishment model. The NSCs...
The current study aimed to identify the radiosensitizing effect of celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, in combination with radiotherapy non-small-cell lung cancer (NSCLC) cells. celecoxib potentiated radiation-induced apoptosis; however, no changes cell cycle distribution and number phosphorylated histone H2AX foci were detected, indicating DNA damage-independent mechanism. In an vivo mouse model, tumor size was significantly decreased group combining radiation...
ATP-binding-cassette family membrane proteins play an important role in multidrug resistance. In this study, we investigated BIRB796, orally active inhibitor of p38 mitogen-activated protein kinase, reversed MDR induced by ABCB1, ABCG2 and ABCC1. Our results showed that BIRB796 could reverse ABCB1-mediated both the drug selected transfected ABCB1-overexpressing cell models, but did not enhance efficacy substrate-chemotherapeutical agents ABCC1 or overexpression cells their parental sensitive...
This study aimed to the value of oxidized low-density lipoprotein (OX-LDL) and related ratio in diagnosis acute cerebral infarction classification infarction. Of 129 patients enrolled this study, 94 with were assigned case group, 35 healthy subjects as control group (n = 35). And then divided into large-artery atherosclerosis (LAA) 61) small-artery occlusion (SAO) 33) according TOAST standard. Plasma OX-LDL levels determined by enzyme-linked immunosorbent assay. OX-LDL/total cholesterol...
Right-to-left shunt (RLS) induced by a patent foramen ovale (PFO) is associated with an increased risk of cryptogenic stroke (CS). However, little known about the relationship between amount RLS and pattern. In this study, we aimed to evaluate distinct clinical features PFO-related CS in different degrees resulting from PFO.This cohort study 222 patients admitted Tongji Hospital 1st May 2014 31st April 2017. All underwent contrast transcranial Doppler examination. And then, 121 (54.5%) were...
The higher than expected PFO rate in CS patients has raised concerns that paradoxical embolism maybe the pathophysiologic mechanism for strokes. However, only a small proportion of pathogenic PFOs cause CS. Therefore, accurate recognition with among all could guide clinical decision making selecting most appropriate treatment. aim this study was to devise new algorithm stratify cryptogenic stroke (CS) into patent foramen ovale (p-PFO)- and non-p-PFO-related patients.A total 1201 acute...
The current study reveals the anticancer potential of oleanolic acid conjugated chitosan nanocomplex (OAC) in lung cancer (LC). Cell counting kit-8 (CCK-8) and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium (MTT) assay were used to detect cell viability, 5-ethynyl-2'-deoxyuridine (EdU) proliferation, flow cytometry TUNEL apoptosis A549 (ATCC
Chronic ethanol exposure leads to permanent damage the central nervous system and produces cognitive deficits such as learning memory impairment. The present study was designed explore therapeutic effect of bone marrow mesenchymal stem cells (BMMSCs) on a rat model alcohol-associated dementia (AAD).Bone were prelabeled with 4',6-diamidino-2-phenylindole directly transplanted into hippocampus AAD rats, an important site alcohol effects that lead deficits. BMMSCs evaluated by observing Morris...
To compare the perioperative parameters between single- and triple-port video-assisted thoracoscopic surgery (VATS) lobectomy in treatment of lung cancer.