A5101843314- Cancer-related Molecular Pathways
- Cancer Research and Treatments
- Telomeres, Telomerase, and Senescence
- Liver Disease Diagnosis and Treatment
- Metabolism, Diabetes, and Cancer
- Hepatocellular Carcinoma Treatment and Prognosis
- Ferroptosis and cancer prognosis
- Chemotherapy-induced cardiotoxicity and mitigation
- Epigenetics and DNA Methylation
- Diet, Metabolism, and Disease
- Cancer therapeutics and mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Cancer-related molecular mechanisms research
- Immune cells in cancer
- Cancer-related gene regulation
- Pancreatic and Hepatic Oncology Research
- Plant-based Medicinal Research
- Growth Hormone and Insulin-like Growth Factors
- Surgical Simulation and Training
- RNA modifications and cancer
- Medical Imaging and Analysis
- Cytokine Signaling Pathways and Interactions
- FOXO transcription factor regulation
- Oral microbiology and periodontitis research
- Chronic Myeloid Leukemia Treatments
Qingdao University
2020-2024
Affiliated Hospital of Qingdao University
2020-2024
Sichuan Agricultural University
2022-2024
The Sixth People's Hospital of Shenyang
2022
Jiangxi Provincial People's Hospital
2021
ShanghaiTech University
2021
Zhejiang University
2019-2020
Sir Run Run Shaw Hospital
2019-2020
Chinese Academy of Sciences
2006-2007
Shanghai Institutes for Biological Sciences
2007
Induction of cyclin-dependent kinase inhibitor p21(Waf1/Cip1/Sdi1) triggers cell growth arrest associated with senescence and damage response. Overexpression p21 from an inducible promoter in a human line induces phenotypic features senescence. cDNA array hybridization showed that expression selectively inhibits set genes involved mitosis, DNA replication, segregation, repair. The kinetics inhibition these on induction parallels the onset arrest, their reexpression release precedes reentry...
Treatment with chemotherapy or radiation is not invariably cytotoxic to all tumor cells. Some of the cells that survive treatment recover and resume proliferation, whereas others undergo permanent growth arrest. To understand nature treatment-induced terminal arrest, colon carcinoma were exposed doxorubicin, surviving separated into proliferating growth-arrested populations. Only displayed phenotypic markers cell senescence failed form colonies. Gene expression was compared between senescent...
Abstract Cisplatin [cis-diaminodichloroplatinum (II) (CDDP)] is one of the most widely used and effective therapeutic agents for many kinds cancers. However, its efficiency limited due to development drug resistance. In this study, we showed that CDDP resistance was associated with AKT1 overexpression gene amplification in human lung cancer cells acquired We forced expression sufficient render resistant, inhibition by dominant negative mutant reversed CDDP-resistant be sensitive. These...
Insulin-like growth factor 1 receptor (IGF-1R) activation is required for prostate cell proliferation. Prostate cancer one of the most commonly diagnosed malignant tumors in Western countries. Overexpression IGF-1R associated with tumor growth. These suggest that inhibitory agents may be preventive and/or therapeutic value. With evidence accumulating a chemopreventive role flavonoids, effects luteolin, bioactive flavonoid, on signaling cells were examined. Luteolin inhibited insulin-like...
Cancer cells frequently use fructose as an alternative energy and carbon source, to fuel glycolysis support the synthesis of various biomacromolecules.Glut5 is only fructose-specific transporter, which lacks ability transport other carbohydrates such glucose galactose.Interplay between inflammatory factors cancer renders tissue environment a predisposing condition for development.Nevertheless, how coordinate with metabolism facilitate tumor growth remains largely elusive.Here we show that...
Fluoride is a common contaminant of groundwater and agricultural commodity, which poses challenges to animal human health. A wealth research has demonstrated its detrimental effects on intestinal mucosal integrity; however, the underlying mechanisms remain obscure. This study aimed investigate role cytoskeleton in fluoride-induced barrier dysfunction. After sodium fluoride (NaF) treatment cultured Caco-2 cells, both cytotoxicity cytomorphological changes (internal vacuoles or massive...
Fluoride exposure is widespread worldwide and poses a significant threat to organisms, particularly their gastrointestinal tracts. However, due limited knowledge of the mechanism fluoride induced intestinal injury, it has been challenging develop an effective treatment. To address this issue, we used series molecular biology in vitro vivo experiments. NaF triggered m
Background.Intervertebral disc degeneration (IDD) is characterized by increased proteolytic degradation of the extracellular matrix (ECM), leading to a loss collagen II and proteoglycan in nucleus pulposus (NP).Although MMP3 has been reported play central role degeneration, it still unknown whether gene therapy targeting can inhibit IDD.Objectives.To investigate lentivirus-mediated knockdown capable attenuating IDD.More importantly, we also explored combined that simultaneously antagonizes...
Laparoscopic liver resection has increased rapidly and procedure almost extended to all the types of resection. Major resections, such as hemihepatectomies, were still innovative procedures in exploration phase continued cautious introduction major laparoscopic resections was recommended by experts. The study aims evaluate safety hemihepatectomy (LH) comparing with open (OH).Patients who underwent Sir Run Shaw Hospital from January 2012 December 2017 reviewed. A 1:1 matched performed between...
Abstract Background: Anthracyclines, including doxorubicin, are some of the most potent anticancer drugs available. However, use doxorubicin as a chemotherapeutic agent is severely hindered by dose-limiting toxicity, particularly cardiotoxicity, while degrading other organ systems. Despite years and amount details published on this drug, understanding its cellular mechanisms still incomplete. Method : Cardiomyocyte grouping was carried out, where H9C2 cardiomyocytes were randomly divided...
Abstract BackgroundAnthracyclines, including doxorubicin, are some of the most potent anticancer drugs available. However, use doxorubicin as a chemotherapeutic agent is severely hindered by dose-limiting toxicity, particularly cardiotoxicity, while degrading other organ systems. Despite years and number details published on this drug, understanding its cellular mechanisms remains limited. MethodCardiomyocyte grouping was carried out, where H9C2 cardiomyocytes were randomly divided into...