A5041548034- High Altitude and Hypoxia
- Neuroscience of respiration and sleep
- Heart Rate Variability and Autonomic Control
- Memory and Neural Mechanisms
- Sleep and Wakefulness Research
- Gut microbiota and health
- Spaceflight effects on biology
- Neural and Behavioral Psychology Studies
- Sleep and related disorders
- Functional Brain Connectivity Studies
- Neural dynamics and brain function
- Stress Responses and Cortisol
- Thermal Regulation in Medicine
- Circadian rhythm and melatonin
- Gout, Hyperuricemia, Uric Acid
- Tryptophan and brain disorders
- Visual perception and processing mechanisms
- Mitochondrial Function and Pathology
- Fluoride Effects and Removal
- Spine and Intervertebral Disc Pathology
- RNA modifications and cancer
- Diet and metabolism studies
- Probiotics and Fermented Foods
- Olfactory and Sensory Function Studies
- Musculoskeletal pain and rehabilitation
Tibet University
2014-2025
South China Normal University
2018-2025
Shaanxi Normal University
2023-2025
Tibet Autonomous Region People's Hospital
2025
Zhejiang Hospital
2024
Beijing Normal University
2022-2024
Peking University
2024
Beijing Children’s Hospital
2024
Chengde Medical University
2022
Shanxi Normal University
2021
The neurocognitive basis of the effect long-term high altitude exposure on voluntary attention is unclear. Using event related potentials, group (people born in low but who had lived at for 3 years) and (living only) were investigated using a spatial discrimination task under perceptual load conditions. responded slower than group, while bilateral N1 activity was found only group. P3 amplitude smaller compared to load. These results suggest that altitudes causes hemispheric compensation...
Though the underlying mechanism remains elusive, a close relationship between psychological stress and intestinal inflammation has been widely accepted. Such link is very important to set basis for our understanding of critical role gut-brain axis (GBA) in homeostatic processes health disease. Probiotics that could confer benefits mental through GBA are referred as “psychobiotics”. This study aimed further determine whether potential psychobiotic strain, Lactobacillus johnsonii BS15 prevent...
Background Hyperuricemia (HUA) is a prevalent metabolic disorder whose development associated with intestinal microbiota. Therefore, probiotics have emerged as potential and safe approach for lowering uric acid (UA) levels. However, the underlying mechanisms of many effective probiotic strains remain unknown. Methods results C57BL/6 mice were randomly divided into two groups: control model groups. The group received 12 weeks potassium oxonate. Through 16s sequencing we found that HUA...
Introduction High-altitude environments have significant effects on brain function, particularly a decline in cognitive due to insufficient oxygen supply. The microbiome-gut-brain axis (MGBA) plays an important role regulating but its specific mechanism of action high-altitude is unclear. Therefore, the aim this study was investigate whether probiotic Lactobacillus johnsonii HL79 could alleviate high altitude-induced dysfunction mice by modulating gut microbiota. Methods and results Sixty...
Abstract Introduction This study aimed to determine the neurocognitive basis underlying effects of long‐term high‐altitude (HA) exposure on working memory (WM). Methods Using event‐related potentials (ERPs), we compared performance an HA group (individuals who had lived at for 3 years but were born and raised low altitude [LA]) that LA only LA) verbal spatial n ‐back tasks (i.e., 1‐ 2‐back load). Results Response accuracy was significantly decreased in comparison both tasks. The P2 amplitude...
Fluoride which is widespread in our environment and food due to its geological origin industrial pollution has been identified as a developmental neurotoxicant. Gut-brain axis provides new insight into brain-derived injury. We previously found the psychoactive effects of probiotic strain, Lactobacillus johnsonii BS15 against fluoride-induced memory dysfunction mice by modulating gut-brain axis. In this study, we aimed detect link between reconstruction gut microbiota through alleviate...
Intestinal microbiota plays an important role in maintaining the microecological balance of gastrointestinal tract various animals. Disturbances intestinal may lead to proliferation potentially pathogenic bacteria that become dominant species, leading immune disorders, inflammation, and other diseases. Numerous studies have been confirmed high-altitude exposure affects normal function intestine composition microbiota. However, it is still necessary reveal changes environments, clarify...
Abstract To investigate the effects of high-altitude exposure on response inhibition, event-related potential (ERP) components N2 and P3 were measured in Go/NoGo task. The participants included an ‘immigrant’ group (who had lived at high altitude for three years but born low altitude) a low-altitude (living only). Although behavioural data showed no significant differences between two groups, delayed latency NoGo-N2 was found compared to group. Moreover, larger smaller amplitudes group, both...
This study used the attention network test (ANT) to evaluate alerting, orienting, and executive efficiencies of related indigenous residents who were born raised until early adulthood in different high-altitude areas (2900-m, 3700-m, 4200-m) at same location (3700-m) where these had been living for approximately 2 years Tibet. We further applied event-related potential (ERP) method identify underlying neurophysiological basis. Based on ANT, we found that, 4200-m residents, function was...
Neck-type cervical spondylopathy (NTCS), a common degenerative disorder affecting the spine, poses challenges for patients and society. Research has demonstrated effectiveness of traditional tuina techniques in treating NTCS, although some limitations still exist. Our study aimed to evaluate combining regular massage with three methods neck movement (TCM) therapy managing utilizing musculoskeletal ultrasound measurements.
Multiple aspects of brain development are influenced by early sensory loss such as deafness. Despite growing evidence changes in attentional functions for prelingual profoundly deaf, the mechanisms underlying these remain unclear. This study investigated relationships between differential attention and resting-state network difference deaf individuals from perspective connectivity. We recruited 36 34 healthy controls (HC). recorded each participant's electroencephalogram (EEG) event-related...
Approximately 400 million people work and live in high-altitude areas suffer from memory dysfunction worldwide. Until now, the role of intestinal flora plateau-induced brain damage has rarely been reported. To address this, we investigated effect on spatial impairment induced by high altitudes based microbiome-gut-brain axis theory. C57BL/6 mice were divided into three groups: control, (HA), antibiotic treatment (HAA) group. The HA HAA groups exposed to a low-pressure oxygen chamber that...
The neurocognitive basis of the effect long-term high altitude exposure on conflict control is unclear. Event related potentials (ERPs) were recorded in a flanker task to investigate influence high-altitude group (who had lived at for three years but born low altitude) and low-altitude (living only). Although was not significant behavioral level, ERPs showed cognitive modulation. interaction between trial type significant: P3 amplitude greater than incongruent trial. This result suggests...
This study aimed to explore the neural mechanisms underlying high-altitude (HA) adaptation and deadaptation in perceptual processes lowlanders. Eighteen healthy lowlanders were administered a facial S1-S2 matching task that included incomplete face (S1) complete (S2) photographs combined with ERP technology. Participants tested at four time points: shortly before they departed HA (Test 1), twenty-five days after entering 2), one week 3) month 4) returning lowlands. Compared those sea level...
Fluoride exposure is widespread worldwide and poses a significant threat to organisms, particularly their gastrointestinal tracts. However, due limited knowledge of the mechanism fluoride induced intestinal injury, it has been challenging develop an effective treatment. To address this issue, we used series molecular biology in vitro vivo experiments. NaF triggered m
Previous studies have reported the slowing of reaction times to attentionally demanding tasks due a reduction in cognitive resource as result chronic high-altitude exposure. However, it is still largely unknown whether this slowness can be attributed attentional allocation change and/or response patterns.
High altitude (HA) exposure reduces the behavioral response to visual attention and neural basis is still largely unclear. The present study explored stimulus-driven goal-directed factors that are hidden within this attentional behavior impairment via a search paradigm in young immigrants Tibet by recording event-related potential (ERPs). We found HA explosure significantly slowed behaviors instead of behaviors. Furthermore, P1, N1, P3 amplitudes collectively indicated poor efficiency entire...
Fluoride (F) exposure was widely reported to be associated with renal diseases. Since absorbed F enters the organism from drinking water mostly through gastrointestinal tract, investigating changes of gut microbes may have profound implications for prevention chronic because increasing evidence supported existence gut-kidney axis. In present study, we aimed explore potential positive effects probiotics on high exposure-induced lesions and dysfunction in mice by modulation colonic microbiota....