A5101850605- Hormonal Regulation and Hypertension
- Renin-Angiotensin System Studies
- Cancer-related molecular mechanisms research
- Ion Transport and Channel Regulation
- Circular RNAs in diseases
- RNA modifications and cancer
- MicroRNA in disease regulation
- Mast cells and histamine
- Lipoproteins and Cardiovascular Health
- Viral Infections and Immunology Research
- Wireless Communication Security Techniques
- Endoplasmic Reticulum Stress and Disease
- Topic Modeling
- Atherosclerosis and Cardiovascular Diseases
- Sentiment Analysis and Opinion Mining
- Injection Molding Process and Properties
- Blood properties and coagulation
- Chromium effects and bioremediation
- Autophagy in Disease and Therapy
- Eicosanoids and Hypertension Pharmacology
- Food Allergy and Anaphylaxis Research
- Inflammasome and immune disorders
- Sulfur Compounds in Biology
- Cholesterol and Lipid Metabolism
- Parathyroid Disorders and Treatments
Southern Medical University
2011-2024
Nanfang Hospital
2023-2024
Beijing Children’s Hospital
2024
Shanghai Jiao Tong University
2023
Nanjing University
2023
Gaochun People's Hospital
2023
Shanghai Ninth People's Hospital
2023
Guangzhou University of Chinese Medicine
2023
Zhujiang Hospital
2018-2022
Zhengzhou University
2021
Kidney fibrosis is the final common pathway of progressive kidney diseases, underlying mechanisms which are not fully understood. The purpose current study to investigate a role Piezo1, mechanosensitive nonselective cation channel, in fibrosis. In human fibrotic kidneys, Piezo1 protein expression was markedly upregulated. abundance kidneys mice with unilateral ureter obstruction (UUO) or folic acid treatment significantly increased. Inhibition nonspecific inhibitor GsMTx4 ameliorated UUO-...
Fluoride is a common contaminant of groundwater and agricultural commodity, which poses challenges to animal human health. A wealth research has demonstrated its detrimental effects on intestinal mucosal integrity; however, the underlying mechanisms remain obscure. This study aimed investigate role cytoskeleton in fluoride-induced barrier dysfunction. After sodium fluoride (NaF) treatment cultured Caco-2 cells, both cytotoxicity cytomorphological changes (internal vacuoles or massive...
Obesity-related kidney disease is related to caloric excess promoting deleterious cellular responses. Accumulation of saturated free fatty acids in tubular cells produces lipotoxicity involving significant dysfunction and injury. The objectives this study were elucidate the role renin-angiotensin system (RAS) activation acid-induced endoplasmic reticulum (ER) stress cultured human proximal tubule epithelial (HK2) mice fed with a high-fat diet. Treatment acid palmitic (PA; 0.8 mM) for 24 h...
Evidence supports an important role of Ca 2+ release-activated channel protein 1 (Orai1)-mediated entry in the development renal fibrosis, a common pathologic feature CKDs that lead to ESRD, but molecular mechanisms remain unclear. We determined Orai1 calcium fibrosis induced by high-fat diet and unilateral ureteral obstruction. Mouse kidneys with had higher levels expression than did without fibrosis. In vivo knockdown adenovirus harboring Orai1–short hairpin RNA or inhibition SKF96365...
Ureteral obstruction is associated with reduced expression of renal aquaporins (AQPs), urinary concentrating defects, and an enhanced inflammatory response, in which the renin-angiotensin system (RAS) may play important role. We evaluated whether RAS blockade by a direct renin inhibitor, aliskiren, would prevent decreased protein AQPs unilateral ureteral (UUO) model what potential mechanisms be involved. UUO was performed for 3 days (3UUO) 7 (7UUO) C57BL/6 mice or without aliskiren...
Background: Chronic kidney diseases (CKD) are usually associated with dyslipidemia. Statin therapy has been primarily recommended for the prevention of cardiovascular risk in patients CKD; however, effects statins on disease progression remain controversial. This study aims to investigate statin treatment renal handling water and animals a high-fat diet. Methods: Retrospective cohort patient data were reviewed protein expression levels aquaporin-2 (AQP2) NLRP3 inflammasome adaptor ASC...
Endoplasmic reticulum (ER) stress has been implicated in some types of glomerular and tubular disorders. The objectives this study were to elucidate the role ER lithium-induced nephrogenic diabetes insipidus (NDI) investigate whether attenuation by 4-phenylbutyric acid (4-PBA) improves urinary concentrating defect lithium-treated rats. Wistar rats received lithium (40 mmol/kg food), 4-PBA (320 mg/kg body wt gavage every day), or no treatment (control) for 2 wk, they dehydrated 24 h before...
Obesity-related kidney diseases are becoming serious health problems worldwide, yet the mechanism by which obesity causes injury is not fully understood. The purpose of current study was to investigate role Mas receptor in lipid-induced injury. In mice fed with high-fat diet (HFD), protein abundance markers autophagy, endoplasmic reticulum stress (ER stress) and apoptosis dramatically increased cortex, markedly prevented deletion (Mas-/-) or antagonist A779. Palmitic acid (PA) induced...
The kinesin-14 motor proteins play important roles in tumor development and drug resistance have been reported as potential biomarkers or therapeutic targets for treatment. However, kinesin family member C2 (KIFC2), one of the members, remains largely unknown prostate cancer (PCa) progression. Here, we used GEO Cancer Genome Atlas datasets, Western blotting, immunohistochemistry analyses to detect KIFC2 expression PCa tissues. Additionally, a series vivo vitro experiments were utilized...
Fluoride exposure is widespread worldwide and poses a significant threat to organisms, particularly their gastrointestinal tracts. However, due limited knowledge of the mechanism fluoride induced intestinal injury, it has been challenging develop an effective treatment. To address this issue, we used series molecular biology in vitro vivo experiments. NaF triggered m
Abstract Background Statins therapy has been primarily recommended for the prevention of cardiovascular risk in patients with chronic kidney diseases. also proved some benefits lipid-induced The current study aims to investigate protection and underlying mechanisms statins on renal tubular injuries induced by cholesterol overloaded. Methods We used suspensions inner medullary collecting duct (IMCD) cells from rat kidneys mouse cell line mpkCCD effect reactive oxygen species (ROS) production...
Changes in RNA editing are closely associated with diseases such as cancer, viral infections, and autoimmune disorders. Adenosine deaminase (ADAR1), which acts on 1, plays a key role adenosine to inosine is potential therapeutic target for these various diseases. The p150 subtype of ADAR1 the only one that contains Zα domain binds both Z-DNA Z-RNA. modulates immune responses may be suitable targets antiviral therapy cancer immunotherapy. In this study, we attempted utilize molecular docking...
Lipotoxicity plays an important role in the pathogenesis of kidney injury. Our previous study demonstrated that activation local renin-angiotensin system (RAS) was involved saturated free fatty acids palmitic acid (PA)-induced tubular cell injuries. The current aims to investigate whether suppression RAS by combination direct renin inhibitor aliskiren and noncanonical pathway chymase chymostatin attenuates PA or cholesterol induced-endoplasmic reticulum stress (ER stress) apopotosis cultured...
Hydrogen sulfide (H2 S) is recognized as a novel gasotransmitter involved in the regulation of nervous system, cardiovascular functions, inflammatory response, gastrointestinal and renal function. Cystathionine β-synthase (CBS) cystathionine γ-lyase (CSE) are major enzymes responsible for H2 S production through desulfuration reactions. reported to play protective role both high-fat diet (HFD)-induced obese diabetic mice. However, synthesizing enzyme not clearly elucidated. The current study...
The direct renin inhibitor aliskiren has been shown to be retained and persist in medullary collecting ducts even after treatment is discontinued, suggesting a new mechanism of action for this drug. purpose the present study was investigate whether regulates renal aquaporin expression improves urinary concentrating defect induced by lithium mice. mice were fed with either normal chow or LiCl diet (40 mmol·kg dry food −1 ·day 4 days 20 last 3 days) 7 days. Some intraperitoneally injected (50...
Background: Drug-metabolizing enzymes and transporters play key roles in drug disposition interactions. The alterations of their expression will influence pharmacokinetics pharmacodynamics. However, the changes disease state are still unclear. Objective: Our study was to investigate main distributed Adriamycin nephropathy rat liver, kidney, intestine. Methods: An intravenous injection with a single dose (6mg/kg) made establish (AN) model normal groups were injected saline. Serum collected...
In this paper, we study the digital marketing where officers (MOs) have to commit creating brand new promotion ads/contents based on understandings of users' needs or preferences. Users' behaviors are typically high dimensional and hard understand. Therefore, dimension reduction from dimensions explainability important help MOs launch operation-friendly marketings. As such, it is natural exploit topic models understand intents (e.g., user-item visits) in case treat each user as a document...
Non-negative matrix factorization (NMF) has gained sustaining attention due to its compact leaning ability. Cancer subtyping is important for cancer prognosis analysis and clinical precision treatment. Integrating multi-omics data beneficial uncover the characteristics of at system-level. A unified multi-view clustering method was developed via adaptive graph sparsity regularized non-negative (multi-GSNMF) subtyping. The local geometrical structures each omics were incorporated into...
In this paper, we study a robust beamforming design for multi-user multiple-input multiple-output secrecy networks with simultaneous wireless information and power transfer (SWIPT). system, an access point, multiple Internet of Things devices under the non-Linear energy harvesting model help one cooperative jammer (CJ). We employ artificial noise (AN) generation to facilitate efficient secure transmission. To achieve fairness, aim maximize minimum harvested among users subject rate...
Abstract Objective Quantitative Real-time PCR (qPCR) is used to detect the differential expression of Circular RNAs in patients Premature Ovarian Insufficiency (POI), order explore new biomarkers POI that can be detected from blood as soon possible. Methods The study collected plasma samples 30 group and normal people meet inclusion criteria, who visited gynecology clinic First Affiliated Hospital Guangzhou University Chinese Medicine July 2019 December 2020. Then circRNAs plasmawere...