A5047485845- Cancer, Hypoxia, and Metabolism
- Chemotherapy-induced cardiotoxicity and mitigation
- Metabolism, Diabetes, and Cancer
- Natural Antidiabetic Agents Studies
- Plant-derived Lignans Synthesis and Bioactivity
- Adipokines, Inflammation, and Metabolic Diseases
- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- Flavonoids in Medical Research
- Viral Infections and Immunology Research
- Cardiovascular Function and Risk Factors
- Cytomegalovirus and herpesvirus research
- RNA Research and Splicing
- Cardiac Imaging and Diagnostics
- Pharmacological Effects of Natural Compounds
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Lipid metabolism and disorders
- Diabetes Treatment and Management
- Cancer, Lipids, and Metabolism
- Cancer Treatment and Pharmacology
- Genomics and Chromatin Dynamics
- Sepsis Diagnosis and Treatment
- Histone Deacetylase Inhibitors Research
- Chemotherapy-induced organ toxicity mitigation
- Fungal Plant Pathogen Control
The Affiliated Yongchuan Hospital of Chongqing Medical University
2016-2024
Chongqing Medical University
2016-2024
Second Xiangya Hospital of Central South University
2022-2024
Central South University
2022-2024
Shanghai Jiao Tong University
2023-2024
Renji Hospital
2023-2024
Shanghai Cancer Institute
2024
Wuhan University
2010-2023
Renmin Hospital of Wuhan University
2011-2021
First Hospital of Jilin University
2013
Recent data suggest that the b-catenin/Tcf-4 signaling pathway plays an important role in human cancer tumorigenesis.However, mechanism of b-catenin/ Tcf-4 tumorigenesis is poorly understood.In this study, we show protein levels were significantly elevated high-grade gliomas comparison with low-grade and correlated AKT2.Reduction activity inhibited glioma cell proliferation invasion vitro tumor growth vivo.This effect bcatenin/Tcf-4 was mediated by AKT2, vivo binding to AKT2 promoter...
PK-120 is a substrate for plasma kallikrein (PK), recently purified from human plasma. Here we have established the cDNA sequence mRNA. The deduced amino of revealed that it consists 902 acid residues with calculated mass 116,423 Da. putative cleavage sites by PK been proposed, suggesting may be precursor bioactive peptide. Most interestingly, showed significant identities to heavy chains (HCs) inter-alpha-trypsin inhibitor (ITI) superfamily.
Osteopontin (OPN) is widely overexpressed in various cancers, including gliomas, and plays an important role tumorigenesis. However, the expression pattern functions of OPN splice variants expressed gliomas remain unclear. The aims our current study were to examine gliomas. In present study, mRNA levels are markedly increased tissues, all also found U251 U87 cells. Furthermore, knock-down regain function experiments designed explore Lentiviral vectors small interference RNA (siRNA) targeting...
Scutellarein (Sc), a natural compound and an active ingredient of Erigeron breviscapus (vant.), shows anti-inflammatory antioxidant properties has the potential for obesity treatment. However, no previous in vivo study been conducted to assess role Sc obesity. This investigated effects on associated hyperlipidemia fatty liver explores underlying mechanisms action mouse model. The was using well-established model induced by high-fat diet (HFD) feeding. Anti-obesity were assessed body weight,...
Objective: Pirarubicin (THP), one of the anthracycline anticancer drugs, is widely used in treatment various cancers, but its cardiotoxicity cannot be ignored. Schisandrin B (SchB) has ability to upregulate cellular antioxidant defense mechanism and promote mitochondrial function status. However, it not been reported whether can resist THP-induced cardiotoxicity. The aim this study was investigate effect SchB on THP mechanism. Methods: rat model induced by established, performed at same...
Pirarubicin (THP) is one of anthracycline anticancer drugs. It widely used in the treatment various cancers, but its hepatotoxicity cannot be ignored. Schisandrin B (SchB) a traditional liver-protecting drug, which has ability to promote mitochondrial function and upregulate cellular antioxidant defense mechanism. However, whether it can resist THP-induced not been reported. The purpose this study was observe explore effect SchB on potential mechanism by adding diet rats with...
Abstract Gallbladder cancer (GBC) is a highly aggressive malignancy lacking clinically available targeted therapeutic agents. Super‐enhancers (SEs) are crucial epigenetic cis‐regulatory elements whose extensive reprogramming drives aberrant transcription in cancers. To study SE GBC, the genomic distribution of H3K27ac profiled multiple GBC tissue and cell line samples to establish landscape its associated core regulatory circuitry (CRC). The biliary lineage factor SOX9 Wnt pathway effector...
To explore the effects of hesperidin on glycolipid metabolic disorders and its mechanism in mice induced by high-fat diet, 40 male C57 were randomly divided into control group, OB low dose group (OB+ hes-low) high hes-high) according to diet. After 16 weeks, body weight, liver index visceral fat all detected. The glucose metabolism indications (blood glucose, insulin levels HOMA-IR) serum lipid evaluated. mRNA expression signaling pathway genes(IR, IRS1, Glut2, Glut4), genes(SREBP-1c, FAS,...
Background. Osteoarthritis (OA) and rheumatoid arthritis (RA) are well-known cause of joint disability. Although they have shown the analogous clinical features involving chronic synovitis that progresses to cartilage bone destruction, pathogenesis initiates perpetuates synovial lesions between RA OA remains elusive. Objective. This study is aimed at identifying disease-specific hub genes, exploring immune cell infiltration, elucidating underlying mechanisms associated with lesion. Methods....
Pirarubicin (THP), one of the anthracycline anticancer drugs, is widely used in treatment various types cancer, but its cardiotoxicity cannot be ignored. Canagliflozin, first sodium‑glucose co‑transporter‑2 inhibitor approved by USA FDA, has been shown to have a significant effect on cardiovascular damage caused diabetes. However, it not reported whether can resist THP‑induced cardiotoxicity. The aim present study was investigate canagliflozin and mechanism. A rat model induced THP...
The cardiotoxicity of pirarubicin (THP) seriously affects its clinical application, which cannot be ignored. antioxidant effect schisandrin B (SchB) has been extensively reported in the context dietotherapy. However, whether this can protect heart from THP damage remains unknown. aim present study was to investigate SchB antagonize THP. Changes electrocardiogram (ECG), echocardiography and serum lactate dehydrogenase, brain natriuretic peptide, creatine kinase MB cardiac troponin T levels...
Kaempferide (Ka), a major natural active component of Tagetes erecta L, has numerous pharmacological effects such as anti-obesity, anticancer, and anti-hypertension. However, there is no clear evidence that Ka directly related to inflammation oxidative stress in obese mice. We aimed explore the on its mechanism.The mice were induced by high-fat diet (HFD). The anti-obesity effect was tested liver body weight, adiposity index, white adipose tissue. Blood sample analysis used detect...