A5008965383- Botany and Plant Ecology Studies
- Bryophyte Studies and Records
- Lichen and fungal ecology
- Aquatic Ecosystems and Phytoplankton Dynamics
- Plant Taxonomy and Phylogenetics
- CRISPR and Genetic Engineering
- Endoplasmic Reticulum Stress and Disease
- Epigenetics and DNA Methylation
- Genetic diversity and population structure
- Evolution and Genetic Dynamics
- RNA modifications and cancer
- Aquatic Ecosystems and Biodiversity
- Autophagy in Disease and Therapy
- Genetic Mapping and Diversity in Plants and Animals
- Mycobacterium research and diagnosis
- Plant and Fungal Species Descriptions
- Collembola Taxonomy and Ecology Studies
- Single-cell and spatial transcriptomics
- Freshwater macroinvertebrate diversity and ecology
- Cholangiocarcinoma and Gallbladder Cancer Studies
- CAR-T cell therapy research
- Genetics and Plant Breeding
- Isotope Analysis in Ecology
- Peatlands and Wetlands Ecology
- Plant Virus Research Studies
Shanghai Jiao Tong University
2022-2024
Shanghai Cancer Institute
2023-2024
Renji Hospital
2023-2024
Shanghai Institute of Hematology
2022-2023
Ruijin Hospital
2022-2023
Center for Life Sciences
2022-2023
State Key Laboratory of Oncogene and Related Genes
2023
Arizona State University
2019-2022
East China Normal University
2013-2019
Fairy Lake Botanical Garden
2018-2019
Although it is well known that microbial populations can respond adaptively to challenges from antibiotics, empirical difficulties in distinguishing the roles of de novo mutation and natural selection have left several issues unresolved. Here, we explore mutational properties Escherichia coli exposed long-term sublethal levels antibiotic norfloxacin, using a accumulation design combined with whole-genome sequencing replicate lines. The genome-wide rate significantly increases norfloxacin...
Mitochondrial genomes of flowering plants (angiosperms) are highly dynamic in genome structure. The mitogenome the earliest angiosperm Amborella is remarkable carrying rampant foreign DNAs, contrast to Liriodendron, other only known early that described as 'fossilized'. distinctive features observed two plant mitogenomes add current confusions what look like. Expanded sampling would provide more details understanding mitogenomic evolution angiosperms. Here we report complete mitochondrial...
Abstract Cellular stresses elicit signaling cascades that are capable of either mitigating the inciting dysfunction or initiating cell death. During endoplasmic reticulum (ER) stress, transcription factor CHOP is widely recognized to promote However, it not clear whether also has a beneficial role during adaptation. Here, we combine new, versatile, genetically modified Chop allele with single analysis and physiological intensity, rigorously examine contribution fate. Paradoxically, find...
Daphnia normally reproduce by cyclical parthenogenesis, with offspring sex being determined environmental cues. However, some females have lost the ability to produce males. Our results demonstrate that this loss of male-producing is controlled a dominant allele at single locus. We identified locus comparing whole-genome sequences 67 nonmale-producing (NMP) and 100 (MP) clones from 5 pulex populations, revealing 132 NMP-linked SNPs 59 indels within 1.1-Mb nonrecombining region on chromosome...
Abstract RNA editing occurs in the organellar mRNAs of all land plants but marchantioid liverworts, making liverworts a perfect group for studying evolution editing. Here, we profiled 42 exemplars spanning ordinal phylogenetic diversity and screened nuclear-encoded pentatricopeptide repeat (PPR) proteins transcriptome assemblies these taxa. We identified 7,428 sites 128 genes from 31 non-marchantioid liverwort species, characterized 25,059 PPR protein sequences. The abundance varies greatly...
In contrast to the highly labile mitochondrial (mt) genomes of vascular plants, architecture and composition mt within main lineages bryophytes appear stable invariant. The available 18 liverwort accessions representing nine genera five orders are syntenous except for Gymnomitrion concinnatum whose genome is characterized by two rearrangements. Here, we expanded number assembled 47, broadening sampling 31 10 spanning much phylogenetic breadth liverworts further test whether evolution...
Nonindigenous members of the
One hundred species and 19 genera (Aneura, Apopellia, Asterella, Calypogeia, Cryptolophocolea, Cylindrocolea, Fossombronia, Haplomitrium, Jackiella, Megaceros, Metacalypogeia, Mnioloma, Nardia, Neolepidozia, Nowellia, Odontoschisma, Saccogynidium, Schiffneria, Syzygiella) are newly added to the liverwort hornwort flora of Vietnam. A revised checklist liverworts hornworts in Vietnam, including 430 79 is presented based on literature present additions.
Genetic variants of mitochondrial DNA at the individual (heteroplasmy) and population (polymorphism) levels provide insight into their roles in multiple cellular evolutionary processes. However, owing to paucity genome-wide data within-individual levels, broad patterns these two forms variation remain poorly understood. Here, we analyze 1,804 complete genome sequences from Daphnia pulex, pulicaria, obtusa. Extensive heteroplasmy is observed D. obtusa, where high level intraclonal divergence...
Simple sequence repeats (SSRs) are thought to be common in plant mitochondrial (mt) genomes, but have yet fully described for bryophytes. We screened the mt genomes of two liverworts (Marchantia polymorpha and Pleurozia purpurea), mosses (Physcomitrella patens Anomodon rugelii) hornworts (Phaeoceros laevis Nothoceros aenigmaticus), detected 475 SSRs. Some SSRs found conserved during evolution, among which except one exists both mosses, all others shared only by liverworts, or hornworts....
Abstract Gallbladder cancer (GBC) is a highly aggressive malignancy lacking clinically available targeted therapeutic agents. Super‐enhancers (SEs) are crucial epigenetic cis‐regulatory elements whose extensive reprogramming drives aberrant transcription in cancers. To study SE GBC, the genomic distribution of H3K27ac profiled multiple GBC tissue and cell line samples to establish landscape its associated core regulatory circuitry (CRC). The biliary lineage factor SOX9 Wnt pathway effector...
ABSTRACT Cellular stresses elicit signaling cascades that are capable of either mitigating the inciting dysfunction or initiating cell death. During endoplasmic reticulum (ER) stress, transcription factor CHOP is widely recognized to promote However, it not clear whether also has a beneficial role during adaptation. Here, we have combined new, versatile, genetically modified Chop allele with single analysis and physiological intensity, rigorously examine contribution fate. Paradoxically,...
YPEL5 is a member of the Yippee-like (YPEL) gene family that evolutionarily conserved in eukaryotic species. To date, physiological function has not been assessed due to paucity genetic animal models. Here, using CRISPR/Cas9-mediated genome editing, we generated stable ypel5-/- mutant zebrafish line. Disruption ypel5 expression leads liver enlargement associated with hepatic cell proliferation. Meanwhile, metabolism and are dysregulated zebrafish, as revealed by metabolomic transcriptomic...
The heterogeneity of lung adenocarcinoma (LUAD) plays a vital role in determining the development cancer and therapeutic sensitivity significantly hinders clinical treatment LUAD.
A new species, Drepanolejeunea glimeae (Marchantiophyta: Lejeuneaceae), is described and illustrated from Brunei Darussalam. It was discovered in the lowland rainforests Ulu Temburong. This species distinguished by absence of gynoecial innovations, erectly to obliquely spreading underleaf lobes, large leaf lobule about 1/2 as long lobe, acute obtuse apex leaf, occasional occurrence ribbon-like regenerants at margins, presence ocelli female bracteole.
Sixty-one species are newly added to the moss flora of Vietnam. Of which, ten genera (Eurhynchiadelphus Ignatov, Huttunen & T.J. Kop., Fleischerobryum Loeske, Forsstroemia Lindb, Geheebia Schimp., Hageniella Broth., Leskeella (Limpr.) Pterogoniadelphus M. Fleisch., Rhizomnium (Mitt. ex Broth.) Scabridens E.B. Bartram and Torrentaria Ochyra) reported for country. is recorded outside China first time. The tropical American Macromitrium longifolium (Hook.) Brid. Asia. occurrence Ctenidium...
Abstract Tertiary lymphoid structures (TLSs) are ectopic aggregates of a number immune cells in nonlymphoid tissues under chronically inflamed environments and cancer. Emergence evidence suggested that TLSs were found diverse cancers have been referred as an independently predictive biomarker for immunotherapy response, especially checkpoint inhibitors. Moreover, the density mature status often positively associated with favorable outcomes cancers. Pancreatic ductal adenocarcinoma (PDAC) is...
With 2 figures and 1 table Abstract Brassica species are important industrial materials. Recently, simple sequence repeat (SSR) markers have become preferred molecular because of their simplicity, high levels polymorphism codominant nature. Numerous SSR been developed in crops, but not every marker has an equal value, they must be tested individually for each application. To develop a set standardized, highly efficient core primers, we screened 190 primer pairs from among over 2353 that...
Non-indigenous Daphnia 'pulex' have been found in many lakes New Zealand (NZ) the past 20 years, suggesting a recent invasion. However, very little is known about origin of invasive D. 'pulex', whether they are pulex or pulicaria, and obligately asexual clones cyclical parthenogens. Furthermore, source time arrival genotype(s) unclear. We address these questions by genomic sequencing populations from 13 on South Island one North Island, NZ. Based ~24,000 monomorphic species-specific markers,...