A5051450028- Chromatin Remodeling and Cancer
- Hedgehog Signaling Pathway Studies
- Genomic variations and chromosomal abnormalities
- Epigenetics and DNA Methylation
- Genetics and Neurodevelopmental Disorders
- Soft tissue tumors and treatment
- Cancer-related Molecular Pathways
- Soft tissue tumor case studies
- Sarcoma Diagnosis and Treatment
- Genomics and Chromatin Dynamics
- Cholangiocarcinoma and Gallbladder Cancer Studies
Shanghai Jiao Tong University
2024
Zhejiang University-University of Edinburgh Institute
2022-2024
Second Affiliated Hospital of Zhejiang University
2024
Desmoid tumors are rare neoplasms that locally invasive. However, optimal treatment strategies for recurrent desmoid remain controversial. High-intensity focused ultrasound (HIFU) has been reported as a noninvasive modality treating tumors. its efficacy against massive or those with complex anatomies remains unclear.We developed new therapeutic strategy called low-power cumulative HIFU and applied it to treat tumors.We retrospectively collected data from 91 patients who underwent after...
Aberrant activation of the Hedgehog (Hh) signaling pathway plays important roles in oncogenesis and therapeutic resistance several types cancer. The clinical application FDA-approved Hh-targeted smoothened inhibitors (SMOi) is hindered by emergence primary or acquired drug resistance. Epigenetic transcriptional-targeted therapies represent a promising direction for developing improved anti-Hh therapies. In this study, we integrated epigenetic/transcriptional-targeted small-molecule library...
Abstract Gallbladder cancer (GBC) is a highly aggressive malignancy lacking clinically available targeted therapeutic agents. Super‐enhancers (SEs) are crucial epigenetic cis‐regulatory elements whose extensive reprogramming drives aberrant transcription in cancers. To study SE GBC, the genomic distribution of H3K27ac profiled multiple GBC tissue and cell line samples to establish landscape its associated core regulatory circuitry (CRC). The biliary lineage factor SOX9 Wnt pathway effector...
Introduction Desmoid tumor (DT) is a rare proliferative disease occurring in connective tissues, characterized by high infiltration and recurrence rates. While surgery remains the primary treatment, its risk high, some extra-abdominal desmoid tumors are inoperable due to their locations. Despite attempts with radiotherapy systemic therapy, efficacy limited. Methods We used low-power cumulative high-intensity focused ultrasound (HIFU) therapy as an initial treatment for patients either...
<div>Abstract<p>Aberrant activation of the Hedgehog (Hh) signaling pathway plays important roles in oncogenesis and therapeutic resistance several types cancer. The clinical application FDA-approved Hh-targeted smoothened inhibitors (SMOi) is hindered by emergence primary or acquired drug resistance. Epigenetic transcriptional-targeted therapies represent a promising direction for developing improved anti-Hh therapies. In this study, we integrated...
<p>The PDF file includes Supplementary Figures S1-S15, Figure Legends, and Table Legends</p>
<div>Abstract<p>Aberrant activation of the Hedgehog (Hh) signaling pathway plays important roles in oncogenesis and therapeutic resistance several types cancer. The clinical application FDA-approved Hh-targeted smoothened inhibitors (SMOi) is hindered by emergence primary or acquired drug resistance. Epigenetic transcriptional-targeted therapies represent a promising direction for developing improved anti-Hh therapies. In this study, we integrated...
<p>The PDF file includes Supplementary Figures S1-S15, Figure Legends, and Table Legends</p>