A5100761347- Esophageal Cancer Research and Treatment
- Gallbladder and Bile Duct Disorders
- RNA modifications and cancer
- Pancreatic and Hepatic Oncology Research
- Cancer Genomics and Diagnostics
- Cancer-related gene regulation
- Cholangiocarcinoma and Gallbladder Cancer Studies
- MicroRNA in disease regulation
- Biliary and Gastrointestinal Fistulas
- Traditional Chinese Medicine Analysis
- Ferroptosis and cancer prognosis
- Sarcoma Diagnosis and Treatment
- Reproductive Biology and Fertility
- Pediatric Hepatobiliary Diseases and Treatments
- Healthcare and Venom Research
- Reproductive System and Pregnancy
- Pediatric Urology and Nephrology Studies
- Kidney Stones and Urolithiasis Treatments
- Cancer-related molecular mechanisms research
- Peptidase Inhibition and Analysis
- Horticultural and Viticultural Research
- Esophageal and GI Pathology
- Chemokine receptors and signaling
- Gastrointestinal disorders and treatments
- Acupuncture Treatment Research Studies
Sun Yat-sen University
2016-2024
Sun Yat-sen University Cancer Center
2016-2024
Zhongshan People's Hospital
2019-2024
Agricultural Genomics Institute at Shenzhen
2023-2024
Chinese Academy of Agricultural Sciences
2023-2024
Ministry of Agriculture and Rural Affairs
2023-2024
Soochow University
2019-2024
Second Affiliated Hospital of Soochow University
2019-2024
Hangzhou Xixi hospital
2023
Zhejiang University
2017-2023
Esophageal squamous cell carcinoma (ESCC) ranks fourth among cancer-related deaths in China due to the lack of actionable molecules. We performed whole-exome and T-cell receptor (TCR) repertoire sequencing on multi-regional tumors, normal tissues blood samples from 39 ESCC patients. The data revealed 12.8% ERBB4 mutations at patient level functional study supported its oncogenic role. 18% patients with early BRCA1/2 variants were associated high-level contribution signature 3, which was...
Seedlessness is a crucial quality trait in table grape (Vitis vinifera L.) breeding. However, the development of seeds involved intricate regulations, and polygenic basis seed abortion remains unclear. Here, we combine comparative genomics, population genetics, quantitative integrative genomics to unravel evolution seedlessness grapes. We generated haplotype-resolved genomes for two seedless cultivars, "Thompson Seedless" (TS, syn. "Sultania") "Black Monukka" (BM). Comparative identified...
Introduction Semen quality is decreasing worldwide, leading to increased male infertility. This study analyzed the microbiota of gut, semen, and urine in individuals with semen abnormalities identify potential probiotics pathogenic bacteria that affect parameters help develop new methods for diagnosis treatment patients abnormalities. Methods We recruited 12 normal (control group), asthenospermia but no hyperviscosity (Group_1), 6 oligospermia (Group_2), 9 severe or azoospermia (Group_3), 14...
E1A Binding Protein P300 (EP300) is one of the mutations genes involved in histone modifications esophageal squamous cell carcinoma (ESCC). However, its clinical relevance, potential function and mechanisms have remained elusive. Methods: Genomic sequencing datas from 325 (ESCC) cases were integrated screened a series frequently mutated modifier genes. EP300 was selected to further analyze significance, RNA-sequencing performed explore mechanism. Results: Of 35 genes, not only significantly...
Abnormal proliferation is significantly associated with the promotion of malignant tumor. Growing evidence suggest that signal pathways p21cdc42/rac1-activated kinase 5 (PAK5) have been found in various tumor progression, however, role PAK5 breast cancer remains largely unclear. We evaluated and p65 staining tissues (BCTs) paired non-cancerous (NTs) using tissue microarray (TMA) technology. The functions were studied vitro vivo. Cell Counting Kit-8 (CCK-8) flow cytometry performed to...
Abstract Background The zinc content in the blood and tumor tissues of patients with osteosarcoma underlying regulation molecular mechanism have not been reported. Methods results This study showed that significantly reduced. CCK-8 Transwell chamber assays revealed treatment inhibited proliferation invasion abilities cells. Western blot analysis indicated expression levels caspase-3 caspase-9 were increased, suggesting growth promoted apoptosis In addition, Wnt-3a β-catenin, marker proteins...
The present study determines the potential antioxidants in Moutan Cortex (MC) and predicts its targets of anti-oxidative activities. quantitative analysis free radical scavenging assays were conducted to detect main components MC assess anti-oxidant grey relational network pharmacology approach employed predict key Six constitutes MCs quantified by high performance liquid chromatography (HPLC) activities evaluated DPPH ABTS methods. Then was acting on activity based chem-bio results....
Abstract Background The poor overall survival of osteosarcoma (OS) underscores the need to explore new therapeutic avenues. Tumor necrosis rate (TNR) after neoadjuvant chemotherapy predicts prognosis. Aims study was investigate safety and activity with camrelizumab (a humanized antibody against PD‐1) in patients resectable OS. Materials & Methods We conducted a prospective, single‐arm, exploratory phase II trial OS patients. Eligible received combined doxorubicin or liposomal...
// Tan-Huan Chen 1, 2, *, ** , Ying-Chun Zhang 3, * Yu-Ting Tan 4, Xin An Cong Xue Ying-Fei Deng Wei Yang Xia Yuan Yan-Xia Shi 1 Department of Medical Oncology, Affiliated Hui Zhou Municipal Central Hospital & Training Base for Masters Sun Yat-Sen Memorial Hospital, University, Huicheng District, Huizhou, Guangdong 516000, P. R. China 2 University Cancer Center, Guangzhou, 510000, P.R. 3 Pathology, 4 Radiotherapy, These authors have contributed equally to this work corporations...
An ultra-performance liquid chromatography coupled with quadrupole time of flight tandem mass spectrometry (UPLC/Q-TOF-MS) was first employed to establish the chromatographic fingerprint and thereby identify major components Yuanhu Zhitong tablet (YZT), a traditional Chinese medicine. Fingerprint established by analyzing 15 different batches YZT, in which we obtained 17 common peaks 18 constituents. Fifteen were identified reference standards literature data, including protopine,...
To evaluate the clinical therapeutic effects and safety on infertility of polycystic ovary syndrome (PCOS) in patients with ovulation induction letrozole treatment formula for regulating menstruation removing phlegm electroacupuncture (EA).A total 120 PCOS were randomized into 3 groups, 40 cases each one. In group A, diane-35 was prescribed oral administration (one tablet a day since 5th menstruation, continuously 21 days). After 1 course (3 months), used 5 days) another months). B, basis as...
Abstracts Munage, an ancient grape variety that has been cultivated for thousands of years in Xinjiang, China, is recognized its exceptional fruit traits. There are two main types Munage: white (WM) and red (RM). However, the lack a high-quality genomic resources impeded effective breeding restricted potential expanding these varieties to other growing regions. In this study, we assembled haplotype-resolved genome assemblies WM RM, alongside integrated whole resequencing (WGS) data...
Zinc is essential for the overall well-being of human body due to its numerous structural, catalytic, and signalling functions. Therefore, maintaining a constant state zinc homeostasis crucial. The disturbances in are linked diseases disorders, including metabolic syndrome neurodegenerative diseases. In this review, we have discussed general overview absorption homeostasis, particularly factors affecting body's mechanisms maintain at both systemic cellular levels.
Most patients with high-grade serous ovarian cancer (HGSOC) experienced disease recurrence cumulative chemoresistance, leading to treatment failure. However, few biomarkers are currently available in clinical practice that can accurately predict chemotherapy response. The tumor immune microenvironment is critical for development, and its transcriptomic profile may be associated response differential outcomes. aim of this study was develop a new predictive signature HGSOC.Two HGSOC...