A5101719430- Cancer-related gene regulation
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Esophageal Cancer Research and Treatment
- Pancreatic and Hepatic Oncology Research
- Glycosylation and Glycoproteins Research
- Cancer Genomics and Diagnostics
- Microtubule and mitosis dynamics
- Cancer-related Molecular Pathways
- Head and Neck Cancer Studies
- Galectins and Cancer Biology
- Biochemical and Molecular Research
- Acute Lymphoblastic Leukemia research
- Proteoglycans and glycosaminoglycans research
- Ubiquitin and proteasome pathways
- Oral Health Pathology and Treatment
- T-cell and Retrovirus Studies
Shanxi Medical University
2008-2025
Esophageal squamous cell carcinoma (ESCC) ranks fourth among cancer-related deaths in China due to the lack of actionable molecules. We performed whole-exome and T-cell receptor (TCR) repertoire sequencing on multi-regional tumors, normal tissues blood samples from 39 ESCC patients. The data revealed 12.8% ERBB4 mutations at patient level functional study supported its oncogenic role. 18% patients with early BRCA1/2 variants were associated high-level contribution signature 3, which was...
Abstract Background Esophageal squamous cell carcinoma (ESCC) is the sixth most lethal cancer worldwide and fourth in China. Genomic characterization of tumors, particularly those different stages, likely to reveal additional oncogenic mechanisms. Although copy number alterations somatic point mutations associated with development ESCC have been identified by array-based technologies genome-wide studies, genomic ESCCs from stages disease has not explored. Here, we performed either...
Histone acetylation modifications can regulate gene transcription and play crucial roles in multiple tumorigeneses processes. YEATS domain proteins are one important type of readers. We have found significant mutations copy number amplifications containing 2 (YEATS2) esophageal squamous cell carcinoma (ESCC) through whole genome sequencing (WGS). However, the function molecular mechanism YEATS2 ESCC remain elusive. Chi-squared test Kaplan-Meier methods were used to analyze clinical...
As a key enzyme in de novo pyrimidine biosynthesis, the expression level of dihydroorotate dehydrogenase (DHODH) has been reported to be elevated various types malignant tumors and its tumor-promoting effect was considered relate synthesis function. Here, we revealed one intriguing potential mechanism that DHODH modulated β-catenin signaling esophageal squamous cell carcinoma (ESCC). We demonstrated directly bound NH2 terminal β-catenin, thereby, interrupting interaction GSK3β with leading...
Background: Cancer genomic studies have identified Zinc Finger Protein 750 (ZNF750) was a novel significantly mutated gene in esophageal squamous cell carcinoma (ESCC).This study designed to determine the clinical value and molecular mechanisms of ZNF750 development ESCC.Methods: Genomic data from 4 reported ESCC cohorts were used analyze mutation profile ZNF750.Tissue microarrays detect its expression 308 samples.Furtherly, effects on proliferation, colony formation, migration invasion...
TSTA3 gene encodes an enzyme responsible for synthesis of GDP-L-fucose as the only donor in fucosylation. This study was designed to explore clinical value, function and underlying mechanism development esophageal squamous cell carcinoma (ESCC).
Aberrant glycosylation has been recognized as a hallmark of cancer and N-glycosylation is one the main types in eukaryotes. Although N-glycoproteomics made contributions to discovery biomarkers variety cancers, less known about abnormal signatures esophageal squamous cell carcinoma (ESCC).In this study, we reported proteomics N-glycoproteomic site-mapping analysis eight pairs ESCC tissues adjacent normal tissues. With zic-HILIC enrichment, TMT-based isobaric labeling, LC-MS/MS analysis,...
Esophageal squamous cell carcinoma (ESCC) is one of the most aggressive cancer types in China. In recent years, progress has been made various genomics including ESCC. However, clinical significance genomic variation ESCC remains poorly defined. present study, sequencing data from 469 cases were analyzed and potential therapeutic targets Druggable Genome Interaction Database (DGIdb) screened. A series target genes pathways identified, which treatment with bortezomib (a specific inhibitor...
// Yanghui Bi 1, 2, 3, * , Ling Zhang 4, Heyang Cui Pengzhou Kong Ting Yan 3 Jiayi Li 5 Zianyi Wang 6 Caixia Cheng 7 Bin Song 8 Yang 9 Enwei Xu 10 Jie Xiaoling Hu 11 Ruyi Shi 12 Yu Qian Fang Hongyi Zhiwu Jia Yanchun Ma Jian Yike Juan Yiqian Liu Yuanfang Zhai Lu Chang Yi Yingchun Feng 13 Haiyan 1,2,3,14 Yanyan 1,2,3,15 Jing Xiaolong 1,2,3,16 and Yongping 1,2,3 1 Translational Medicine Research Center, Shanxi Medical University, Taiyuan, Shanxi, PR China 2 Key Laboratory of Carcinogenesis...
Objective To investigate the role of ECRG2 gene in migration and invasion human fibrosarcoma HT1080 cells. Methods Tet-on system was used to set up ECRG2-inducible cell clones.Knockdown done by stably expressing short hairpin RNA (shRNA) specific for mRNA a highly invasive line HT1080. The expressions proteins were detected Western blotting assay. Wound-healing scrape assay transwell performed assess effect on properties vitro. Results most effective ECRG2siRNA interference inducible...
Objective To investigate the role of ECRG2,a novel tumor suppressor gene,in spindle assembly checkpoint. Methods Using siRNA approach to deplete expression ECRG2, using immunofluorescence test distribution ECRG2,using Western blotting examine cell cycle proteins.Results ECRG2 localized centrosomes during interphase and kinetochores mitosis.Further analysis revealed that participates in checkpoint.Depletion abolished checkpoint.Conclusion Our results indicated is important for ensuring...