A5031898500- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- RNA modifications and cancer
- Circular RNAs in diseases
- Cancer Genomics and Diagnostics
- Cancer-related gene regulation
- Underwater Acoustics Research
- Advanced Image Processing Techniques
- Ferroptosis and cancer prognosis
- Epigenetics and DNA Methylation
- RNA Research and Splicing
- Esophageal Cancer Research and Treatment
- Advanced Vision and Imaging
- Image and Signal Denoising Methods
- Protein Interaction Studies and Fluorescence Analysis
- Liver Disease Diagnosis and Treatment
- Speech and Audio Processing
- Genomic variations and chromosomal abnormalities
- Bioinformatics and Genomic Networks
- Autophagy in Disease and Therapy
- Genetic factors in colorectal cancer
- Reproductive System and Pregnancy
- Endometriosis Research and Treatment
- Blind Source Separation Techniques
- Carbohydrate Chemistry and Synthesis
Shanxi Medical University
2017-2025
Hunan Normal University
2025
Hunan Provincial People's Hospital
2025
Institute of Acoustics
2018-2025
Chinese Academy of Sciences
2022
Jiangnan University
2018
Capital Medical University
2015
Second Affiliated Hospital of Nanchang University
2014
Nanchang University
2014
While the potential of patient-derived organoids (PDOs) to predict patients' responses anti-cancer treatments has been well recognized, lengthy time and low efficiency in establishing PDOs hamper implementation PDO-based drug sensitivity tests clinics. We first adapt a mechanical sample processing method generate lung cancer (LCOs) from surgically resected biopsy tumor tissues. The LCOs recapitulate histological genetic features parental tumors have expand indefinitely. By employing an...
We aimed to assess the global impact of chronic kidney disease (CKD) attributable dietary risk factors. The research utilized data from Global Burden Disease Study 2021 evaluate age-standardized mortality rates (ASMR), disability-adjusted life years (DALYs), and estimated annual percentage changes (EAPCs) linked CKD resulting From 1990 2021, both ASMR DALY rate (ASDR) for factors exhibited an overall increasing trend globally. EAPC was 0.65, while DALYs stood at 0.39. Among examined, a diet...
Histone acetylation modifications can regulate gene transcription and play crucial roles in multiple tumorigeneses processes. YEATS domain proteins are one important type of readers. We have found significant mutations copy number amplifications containing 2 (YEATS2) esophageal squamous cell carcinoma (ESCC) through whole genome sequencing (WGS). However, the function molecular mechanism YEATS2 ESCC remain elusive. Chi-squared test Kaplan-Meier methods were used to analyze clinical...
// Lu Kong 1 , Qi Hao Ying Wang Ping Zhou 2 Binbin Zou and Yu-xiang Zhang 1,3,4 Department of Biochemistry Molecular Biology, School Basic Medical Sciences, Capital University, Beijing, China Bioinformatics Computer Science, Biomedical Engineering, 3 Cancer Institute 4 Beijing Key Laboratory for Invasion Metastasis Research, Correspondence to: Zhang, email: Keywords : non-coding microRNAs, p53, cervical cancer, VTRNA2-1-5p, apoptosis Received December 17, 2014 Accepted July 02, 2015...
Background: Cancer genomic studies have identified Zinc Finger Protein 750 (ZNF750) was a novel significantly mutated gene in esophageal squamous cell carcinoma (ESCC).This study designed to determine the clinical value and molecular mechanisms of ZNF750 development ESCC.Methods: Genomic data from 4 reported ESCC cohorts were used analyze mutation profile ZNF750.Tissue microarrays detect its expression 308 samples.Furtherly, effects on proliferation, colony formation, migration invasion...
Abstract Background Circular RNAs (circRNAs) are known to play a crucial role in variety of malignancies. However, the precise circRNAs cervical squamous cell carcinoma (CSCC) remains largely unknown. Methods The expression circ0001955 was determined by real-time quantitative PCR and fluorescence situ hybridization. To examine effects on CSCC metastasis growth, functional experiments were conducted vitro vivo. Mechanistically, nucleocytoplasmic separation, dual luciferase reporter assay, RNA...
Circular RNAs (circRNAs) are regulatory molecules that participate in the occurrence, development and progression of tumors. To obtain a complete blueprint cervical carcinogenesis, we analyzed temporal transcriptomic landscapes mRNAs circRNAs. Microarrays were performed to identify circRNA mRNA expression profiles squamous cell carcinoma (CSCC) high-grade intraepithelial lesion (HSIL) patients compared with normal controls (NC). Short time-series miner (STEM) was utilized characterize...
Super-Resolution is a technique for recovering image details based on available information, avoiding quality degradation by increasing an image's resolution. Despite the great success of deep learning-based SR models, they are rarely applied to underwater sonar scenarios due lack datasets and difficulty in texture details. To address these challenges, we propose multi-headed generative adversarial network (MHGAN) super-resolution images. The main body generator designed with introduced...
Due to the lack of effective diagnostic markers and therapeutic targets, esophageal squamous cell carcinoma (ESCC) shows a poor 5 years survival rate less than 30%. To explore potential targets ESCC, we integrated reanalyzed mutation data WGS (whole genome sequencing) or WES exome from total 1,145 samples in 7 large ESCC cohorts, including 270 gene expression data. Two new signatures 20 driver genes were identified our study. Among them, AP3S1, MUC16, RPS15 reported for first time. We also...
Broadband parametric acoustic arrays appear to offer advantages for shallow water sub‐bottom profiling. In this paper, the performance of a broadband array system was experimentally evaluated. tank experiments using nonlinear parabolic wave (KZK) equation, directivity, source level, length, and penetration depth were Based on Berktay’s far‐field solution, system’s emission signal designed. According sea trials as designed, clear profile obtained. Moreover, buried pipelines in seabed...
Cervical cancer (CC) is one of the most common malignant tumors in women. In order to identify functional roles and interaction between mRNA non-coding RNA (ncRNA, including lncRNA, circRNA miRNA) CC cisplatin (DDP) resistance, transcription profile analysis was performed a regulatory model DDP resistance proposed.In this study, whole-transcriptome sequencing conducted study ncRNA profiles parental SiHa cells resistant SiHa/DDP cells. Gene ontology (GO) Kyoto Encyclopedia Genes Genomes...
Introduction Low-grade gliomas (LGG) represent a heterogeneous and complex group of brain tumors. Despite significant progress in understanding managing these tumors, there are still many challenges that need to be addressed. Glycosylation, common post-translational modification proteins, plays role tumor transformation. Numerous studies have demonstrated close relationship between glycosylation modifications progression. However, the biological function glycosylation-related genes LGG...
Aberrant glycosylation is one of the hallmarks cancer. The profile glycoprotein expression caused by abnormal has been revealed, while glycogenes that may disturb structure glycans have not yet identified in esophageal squamous cell carcinoma (ESCC). Genomic alterations driven differentially expressed ESCC were compared with matched normal tissues multi-omics analysis. Immunohistochemistry, MTT, colony formation, transwell assays, subcutaneous tumor formation experiments and tail vein...
Abstract Lysosomal dysfunction can drive carcinogenesis. Lysosomal‐associated membrane protein 3 (LAMP3), is a member of the Lysosome Associated Membrane Proteins and involved in malignant phenotype such as tumour metastasis drug resistance, while mechanisms that regulate progression remain vague. Our study aims to provide more systematic comprehensive understanding role LAMP3 various cancers by databases.We explored pan‐cancer using The Cancer Genome Atlas (TCGA) Genotype‐Tissue Expression...
<title>Abstract</title> Background Circular RNAs (circRNAs) are known to play a crucial role in variety of malignancies. However, the precise circRNAs cervical squamous cell carcinoma (CSCC) remains largely unknown. Methods The expression circ0001955 was determined by real-time quantitative PCR and fluorescence situ hybridization. To examine effects on CSCC metastasis growth, functional experiments were conducted vitro vivo. Mechanistically, nucleocytoplasmic separation, dual luciferase...
This study was purposed to investigate the expression of heat shock protein 90 (HSP90) in peripheral blood plasma patients with multipl myeloma (MM), and explore its possible role pathogenesis MM, relationship treatment, prognosis outcome patients. The samples from 58 MM 20 healthy volunteers were collected. concentration HSP90 measured by ELISA. results showed that significantly higher than [(32.398 ± 3.674) vs (25.762 2.916) ng/ml] (P < 0.001). positively correlation International Staging...
As an indispensable sensor for obtaining ocean resources, sonar can provide rich underwater observation information. However, due to the limitations of equipment, resolution images collected is always low, resulting in some inexplicit targets. To obtain high-resolution information, image super-resolution reconstruction, as efficient method, significantly reduce hardware requirements. Super-resolution refers technology restoring details based on known achieve high-quality images, we propose a...