A5102015498- Cancer-related molecular mechanisms research
- Nanoplatforms for cancer theranostics
- MicroRNA in disease regulation
- RNA modifications and cancer
- Graphene and Nanomaterials Applications
- Viral-associated cancers and disorders
- Microtubule and mitosis dynamics
- Cancer-related gene regulation
- Extracellular vesicles in disease
- Circular RNAs in diseases
- Virus-based gene therapy research
- Marine Sponges and Natural Products
- Sesquiterpenes and Asteraceae Studies
- CRISPR and Genetic Engineering
- Ginseng Biological Effects and Applications
- Histone Deacetylase Inhibitors Research
- 14-3-3 protein interactions
- Ubiquitin and proteasome pathways
- Plant chemical constituents analysis
- Nanoparticle-Based Drug Delivery
- Neuroblastoma Research and Treatments
Jilin University
2021-2022
Second Affiliated Hospital of Nanjing Medical University
2020
Tiangong University
2018
Tongue squamous cell carcinoma (TSCC) is an oral cancer, with high malignancy and frequent early migration invasion. Only a few drugs can treat tongue cancer. Ginsenoside Rd ginseng extract anti-cancer effects. Many noncoding RNAs are abnormally expressed in thus influencing its occurrence development. H19 miR-675-5p promote cancer growth. This study aimed to analyze the regulation effect of ginsenoside on cancer.We used CCK8 flow cytometry growth apoptosis. Transwell assay was assess...
Cucurbitacin B (CuB), a natural product, has anti-tumor effects on various cancers. In order to investigate the expression of long non-coding RNAs (lncRNA), we carried out RNA sequencing (RNA-seq) and quantitative PCR (qPCR). The data indicated that CAL27 SCC9 tongue squamous cell carcinoma (TSCC) cells had reduced X-inactive specific transcript (XIST) after CuB treatment. Moreover, our results showed increased XIST in human cancer. this study, treatment inhibited proliferation, migration...
Many findings have demonstrated long noncoding RNAs (lncRNAs) as crucial regulatory molecules in the progression of osteosarcoma. The aim this study was to explore roles and mechanisms LncRNA LINC00689 (LINC00689) osteosarcoma.Differential levels miR-655 osteosarcoma samples cell lines were analyzed by quantitative Real Time-Polymerase Chain Reaction (qRT-PCR). associations between expression prognostic significance patients using a series statistical assays. Loss-of-function...
Although the therapeutic strategy showed significant improvement, effect was poor on metastases in tongue squamous cell carcinoma (TSCC) which is most malignant tumor found head and neck. Chrysin, similar to flavonoids, plays an antitumor role by regulating expression of ncRNAs many kinds cancers. Compared gold nanoparticles (AuNPs) provide a novel insight into inhibiting cancer growth via photothermal therapy (PPT) irradiated near-infrared radiation (NIR). However, flavonoids AuNPs lack...
<b><i>Purpose:</i></b> Osthole is an agent isolated from <i>Cnidium monnieri</i> (L.) Cusson and has been used to treat several disorders. Corneal neovascularization a sight-threatening condition associated with inflammatory or infectious ocular In this study, we investigated the anti-angiogenic effects of osthole on corneal underlying mechanism. <b><i>Methods:</i></b> MTT assay, HE staining, calcein-AM/propidium iodide staining was...
// Yanghui Bi 1, 2, 3, * , Ling Zhang 4, Heyang Cui Pengzhou Kong Ting Yan 3 Jiayi Li 5 Zianyi Wang 6 Caixia Cheng 7 Bin Song 8 Yang 9 Enwei Xu 10 Jie Xiaoling Hu 11 Ruyi Shi 12 Yu Qian Fang Hongyi Zhiwu Jia Yanchun Ma Jian Yike Juan Yiqian Liu Yuanfang Zhai Lu Chang Yi Yingchun Feng 13 Haiyan 1,2,3,14 Yanyan 1,2,3,15 Jing Xiaolong 1,2,3,16 and Yongping 1,2,3 1 Translational Medicine Research Center, Shanxi Medical University, Taiyuan, Shanxi, PR China 2 Key Laboratory of Carcinogenesis...
Objective To investigate the effect and mechanism of ubiquitin-specific processing peptidase 10 (USP10) on gemcitabine resistance pancreatic cancer. Methods (1) The 50% inhibiting concentration (IC50) USP10 in PANC-1, BxPC-3 SW1990 cell lines cancer was detected by CCK8 assay. (2) expression BxPC-3, SW1990-GEM Western blot. (3) Small interfering RNA (siRNA) SW1900 conducted, siRNA USP10siRNA were transected then respectively allocated into control group group. (4) IC50 between 2...