A5020208227- Phytochemistry and Biological Activities
- Advanced Proteomics Techniques and Applications
- Electrocatalysts for Energy Conversion
- Catalytic Processes in Materials Science
- Bioactive Natural Diterpenoids Research
- Plant-based Medicinal Research
- Natural product bioactivities and synthesis
- Nanoporous metals and alloys
- Radioactive element chemistry and processing
- Nanocluster Synthesis and Applications
- Mass Spectrometry Techniques and Applications
- Biological and pharmacological studies of plants
- Tea Polyphenols and Effects
- Ginseng Biological Effects and Applications
- Coffee research and impacts
- Viral Infections and Immunology Research
- Graphene research and applications
- Glycosylation and Glycoproteins Research
- Drug Transport and Resistance Mechanisms
- Berberine and alkaloids research
- Biological Activity of Diterpenoids and Biflavonoids
- Metabolomics and Mass Spectrometry Studies
- Adsorption and biosorption for pollutant removal
- Molecular Junctions and Nanostructures
- nanoparticles nucleation surface interactions
Yunnan Agricultural University
2020-2025
Northern Jiangsu People's Hospital
2023-2024
Yangzhou University
2023-2024
Tianjin University of Technology
2017-2024
Anhui Normal University
2024
Gansu Provincial Hospital
2024
Qingdao University of Technology
2024
Chinese Academy of Sciences
2016-2023
Shanghai Institute of Organic Chemistry
2023
Liaocheng University
2023
Solar-driven carbonylation with CO2 replacing toxic CO as a C1 source is of considerable interest; however it remains great challenge due to the inert molecule. Herein, we integrate cobalt single-site and ultrafine CuPd nanocluster catalysts into porphyrin-based metal-organic framework construct composite photocatalysts (Cu1Pd2)z@PCN-222(Co) (z = 1.3, 2.0, 3.0 nm). Upon visible light irradiation, excited porphyrin can concurrently transfer electrons Co single sites nanoclusters, providing...
5-Fluorouracil (5-Fu) has been widely used as a first-line drug for colorectal cancer (CRC) treatment but limited by resistance and severe toxicity. The chemo-sensitizers that augment its efficiency overcome limitation are urgently needed. Gypenosides (Gyp), the main components from Gynostemma pentaphyllum (Thunb.) Makino, shown potential anti-tumor property with little side-effect. Here, we carefully explored chemo-sensitization of Gyp to potentiate effect 5-Fu in vitro vivo.3-(4,...
Due to the unique properties of OCF3 group, trifluoromethyl ether compounds play an important role in pharmaceuticals and agrochemicals. Recently, considerable attention has been focused on development practical convenient reagents for direct incorporation group into organic compounds. Herein, we reported a new trifluoromethoxylating reagent N-trifluoromethoxyphthalimide (Phth-OCF3). The was stable solid released anion under mild reaction conditions. We demonstrated application Phth-OCF3...
Rare ent-abietane-rosane diterpenoid heterodimers, Bisebracteolasins A and B (1 2, respectively), were isolated from the roots of Euphorbia ebracteolata Hayata. Their structures absolute configurations elucidated spectroscopic data X-ray diffraction analysis. Compounds 1 2 exhibited moderate cytotoxic effects against five cancer cell lines. Compound showed more effective antiproliferative activities human tumour cells, HL-60 SMMC-7721, with IC50 values 2.61 4.08 μM, respectively, than 2....
The first oxidative chloro- and bromodifluoromethylation of phenols with (CH3)3SiCF2X CuX (X = Cl or Br) in the presence Selectfluor under mild reaction conditions was developed. This protocol provided a practical efficient method for synthesis diverse range biologically valuable synthetically challenging bromodifluoromethyl aryl ethers. Preliminary mechanistic studies suggest that this proceeded through difluorocarbene-involved coupling process.
Traumatic brain injury (TBI) can lead to short-term and long-term physical cognitive impairments, which have significant impacts on patients, families, society. Currently, treatment outcomes for this disease are often unsatisfactory, due at least in part the fact that molecular mechanisms underlying development of TBI largely unknown. Here, we observed upregulation Piezo2, a key mechanosensitive ion channel protein, injured tissue mouse model induced by controlled cortical impact....
The semi-dry fermentation processing (SFP) of Coffea arabica is a traditional primary method in the coffee industry, which crucially impacts coffee’s flavor. To further obtain useful information on microbial communities and chemical compounds during SFP C. from Yunnan, China, community structures differentially changed non-volatile (DCnVCs) were comprehensively analyzed. results showed that Tatumella, Staphylococcus, Klebsiella, Brevundimonas, Gluconobacter most prevalent bacteria genera,...
Background: Centranthera grandiflora Benth is commonly utilized in China to take advantage of its purported health benefits. Methods: Here, the chemical composition, nutritional value, and bioactivity C. extract (CGE) are characterized, mechanisms through which it functions were explored. Results: CGE was found exhibit a favorable biosafety profile, especially due high amino acid mineral contents. A UPLC-ESI-Q-TOF/MS approach identified 20 compounds. Through network pharmacology analyses,...
ABSTRACT Coffee is a globally popular beverage and significant agricultural economic crop in planted countries regions. To understand the influence of primary processing on coffee, microbial communities chemical compounds were analyzed using high‐throughput sequencing HPLC‐MS/MS metabolomics to confirm dynamic changes them during dry Coffea arabica from Yunnan, China. The results showed that Tatumella , Klebsiella Gluconobacter Brevundimonas Staphylococcus at bacterial general level Candida...
Using Ca(NO3)2·4H2O, (NH4)2HPO4 and urea as the starting raw materials, hydroxyapatite (HAP) crystals were successfully prepared at low temperature (95 °C) by changing pressure inside autoclave. The HAP characterized XRD, SEM, HRTEM, FTIR technologies. XRD patterns indicated that increasing is helpful to improve purity of product change autoclave has a great effect on growth crystal planes. various planes was certified analysis HRTEM micrographs. SEM images illustrated morphology changed...
Metal-organic frameworks (MOFs) are a class of crystalline porous materials with reticular architectures. Precisely tuning pore environment MOFs has drawn tremendous attention but remains great challenge. In this work, we demonstrate competitive coordination approach to synthesize series zirconium-metalloporphyrinic through introducing H2O and monocarboxylic acid as modulating reagents, in which well-ordered mesoporous channels could be observed clearly under conventional transmission...
Background: Meconopsis horridula Hook (M. horridula) has been used as a traditional Tibetan medicine to relieve heat and pain well mobilize static blood, it is recognized good treatment for bruises. This study the first trial evaluate tumor inhibitory activity of M. extract its underlying mechanism in hope providing evidence support anticancer function horridula. Methods Results: was cytotoxic L1210 cells dose- time-dependent manner. SEM (scanning electron microscope) observation revealed...
Modification of proteins with 4-hydroxynonenal (HNE) is known to alter the function and regulate associated biological processes in eukaryotic cells. The development mass spectrometry (MS) makes high-throughput analysis HNE modification accessible. However, identification still hampered by low frequency this modification. Therefore, only a limited number sites have been identified. enrichment HNE-modified peptides critical for MS because its abundance. Herein, we explored novel strategy...
In practical applications, the coalescence of metal nanoparticles (NPs) is a major factor affecting their physical chemistry properties. Currently, due to lack understanding atomic-level mechanisms during nucleation and growth stages coalescence, correlation between different dynamic factors in NP unclear. this study, we used advanced situ characterization techniques observe formation atomic material transport channels (Au chains) initiation nucleation. We focused on movement migration...
The aim of this study was to compare the cell membrane damage induced by ultrasound at different intensities between MCF-7/ADR cells and MCF-7 cells.Tumor in culture dishes (35 mm diameter) were exposed planner range from 0.25 W/cm(2) 0.75 for 60s. viability determined 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay Guava Viacount assay. integrity estimated flow cytometry using propidium iodide (PI) staining cellular uptake fluorescein isothiocyanate-dextran...