A5021173503- Coronary Interventions and Diagnostics
- Cardiac Imaging and Diagnostics
- Antiplatelet Therapy and Cardiovascular Diseases
- Acute Myocardial Infarction Research
- Cardiac Valve Diseases and Treatments
- Cerebrovascular and Carotid Artery Diseases
- Peripheral Artery Disease Management
- Atrial Fibrillation Management and Outcomes
- Cardiovascular Function and Risk Factors
- Lipoproteins and Cardiovascular Health
- Aortic aneurysm repair treatments
- Venous Thromboembolism Diagnosis and Management
- Obstructive Sleep Apnea Research
- Cardiac Arrhythmias and Treatments
- Atherosclerosis and Cardiovascular Diseases
- Heart Failure Treatment and Management
- Cardiac and Coronary Surgery Techniques
- Heart rate and cardiovascular health
- Cardiovascular Disease and Adiposity
- Vascular Procedures and Complications
- RNA Research and Splicing
- Cardiac Fibrosis and Remodeling
- Aortic Thrombus and Embolism
- Ion Channels and Receptors
- Hippo pathway signaling and YAP/TAZ
Nanjing Medical University
2015-2024
Icahn School of Medicine at Mount Sinai
2017-2020
First Hospital of Lanzhou University
2018
Cardiovascular Institute of the South
2018
Mount Sinai Medical Center
2017-2018
Lanzhou University
2018
University of Dundee
2018
NYU Langone Health
2018
Beijing Friendship Hospital
2017
Capital University
2017
The aim of this study was to explore the difference in target vessel failure (TVF) 3 years after intravascular ultrasound (IVUS) guidance versus angiographic among all comers undergoing second-generation drug-eluting stent (DES) implantation.The multicenter randomized ULTIMATE (Intravascular Ultrasound Guided Drug Eluting Stents Implantation "All-Comers" Coronary Lesions) trial showed a lower incidence 1-year TVF IVUS-guided DES implantation compared with guidance. However, 3-year clinical...
There is a paucity of data from large cohort studies examining the prognostic significance obstructive sleep apnea (OSA) in patients with coronary artery disease. We hypothesized that OSA predicts subsequent major adverse cardiac and cerebrovascular events (MACCEs) undergoing percutaneous intervention.The Sleep Stent Study was prospective, multicenter registry successfully treated intervention 5 countries. Between December 2011 April 2014, 1748 eligible were prospectively enrolled. The 1311...
This study sought to compare angiographic endpoints at one-year follow-up after a drug-eluting stent implantation guided by either intravascular ultrasound (IVUS) or angiography in patients with chronic total occlusion (CTO) lesions.Patients least one CTO lesion recanalised successfully were randomly assigned the IVUS-guided angiography-guided group. The use of IVUS for penetration true lumen and optimisation expansion was only done primary endpoint in-stent late loss (LLL) follow-up. A 230...
Abstract A series of novel graft copolymers, poly( L ‐lysine)‐ ‐poly(ethylene glycol) (PLL‐ g ‐PEG) with 28, 46, and 96 % the PEG chains carrying a terminal nitrilotriacetic acid (NTA) group, have been synthesized. Through electrostatic interactions, these polycationic copolymers assemble spontaneously from aqueous solution onto negatively charged surfaces, forming polymeric monolayers that present NTA groups at controlled surface densities. Such NTA‐presenting surfaces on highly PEGylated...
Background: The importance of intravascular ultrasound (IVUS)-guided stenting the unprotected left main coronary artery (ULMCA) remains controversial and has not been fully studied in subset patients with ULMCA. This study evaluated clinical outcome IVUS-guided using a drug-eluting stent for Methods: A total 1,016 consecutive ULMCA stenosis who underwent implantation from January 2006 to December 2011 were prospectively registered. primary endpoint this nonrandomized registry was rate...
Atherosclerosis-related cardiovascular diseases are leading causes of mortality worldwide, characterized by the development endothelial cell dysfunction, increased oxidized low-density lipoprotein uptake macrophages, and ensuing formation atherosclerotic plaque. Local blood flow patterns cause uneven lesion distribution, dysfunction caused disturbed is an early step in atherosclerosis. The present research aims to elucidate mechanism underlying regulation Neuropilin 2 (NRP2) under low shear...
Objective: It is controversial whether endothelium-dependent relaxation resistance to inhibitors of nitric oxide (NO) and prostacyclin synthases completely attributed endothelium-derived hyperpolarizing factor (EDHF). This study examined NO release K+ channels involved in hyperpolarization NG-nitro-l-arginine (l-NNA) indomethacin coronary arteries with emphasis on the microarteries. Methods: release, isometric force, membrane potential porcine were measured using a NO-specific electrode,...
ABSTRACT SC1011 (sufenidone) is a novel pyridone derivative with therapeutic potential for idiopathic pulmonary fibrosis (IPF). Two Phase 1 studies evaluated the safety and pharmacokinetics of single (SAD) multiple ascending doses (MAD) immediate‐release (IR) modified‐release (MR) oral formulations in healthy adult subjects. In 1a, subjects were randomized to receive IR or placebo SAD (50 mg‐300 mg) MAD (100 mg 200 twice daily 7 days. The 1b study consisted three treatment groups that...
Background: Although stent underexpansion on intravascular ultrasound (IVUS) has been a major predictor for adverse outcomes in previous studies, these studies have primarily focused angiographic restenosis or repeat revascularization with short-term follow-up. This study sought to evaluate the long-term benefit of different criteria IVUS-defined optimal expansion hard clinical outcomes. Methods: From pooled data 2 randomized trials, IVUS-XPL (Impact Intravascular Ultrasound Guidance...
Background: There are 2 competing approaches to optimize drug-eluting stent implantation: angiography-guided routine postdilation or intravascular ultrasound (IVUS) guidance. Methods: From the pooled data of randomized trials, IVUS-XPL (Impact Intravascular Ultrasound Guidance on Outcomes Xience Prime Stents in Long Lesions) and ULTIMATE (Intravascular Guided Drug Eluting Implantation All-Comers Coronary Lesions), that compared IVUS- versus implantation, we 1037 patients (1265 lesions) with...
Background: Prognostic impact of residual anatomic disease burden after functionally complete percutaneous coronary intervention (PCI), defined by post-PCI fractional flow reserve (FFR) >0.80 would be a clinically relevant question. The current study evaluated clinical outcomes at 2 years according to Synergy Between Percutaneous Coronary Intervention With Taxus and Cardiac Surgery (SYNTAX) score (RSS) in patients who underwent revascularization. Methods: A total 1910 (2095 revascularized...