A5101785854- Cardiac Imaging and Diagnostics
- Pulmonary Hypertension Research and Treatments
- Coronary Interventions and Diagnostics
- Aortic aneurysm repair treatments
- Cardiovascular Issues in Pregnancy
- Acute Myocardial Infarction Research
- Cardiovascular Health and Disease Prevention
- Nitric Oxide and Endothelin Effects
- Pelvic floor disorders treatments
- Diverticular Disease and Complications
- Aortic Disease and Treatment Approaches
- Cardiovascular Function and Risk Factors
- Vascular Anomalies and Treatments
- Gastrointestinal motility and disorders
- Cardiac Valve Diseases and Treatments
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Elasticity and Material Modeling
- Congenital gastrointestinal and neural anomalies
- Parathyroid Disorders and Treatments
- Diet and metabolism studies
- Infectious Aortic and Vascular Conditions
- Redox biology and oxidative stress
- Gastrointestinal disorders and treatments
- Lipoproteins and Cardiovascular Health
- Anorectal Disease Treatments and Outcomes
Huazhong University of Science and Technology
2005-2024
Tongji Hospital
2005-2024
California Medical Innovations Institute
2017-2024
State Key Laboratory of Food Science and Technology
2022
Nanchang University
2022
Indiana University – Purdue University Indianapolis
2008-2013
University of Indianapolis
2013
World Health Organization (WHO) group 1 pulmonary arterial hypertension (PAH) is a progressive, debilitating disease. Previous observational studies have demonstrated that artery denervation (PADN) reduces pressures in PAH. However, the safety and effectiveness of PADN not been established randomized trial. The aim this study was to determine treatment effects patients with Patients WHO PAH taking PAH-specific drugs for at least 30 days were enrolled multicenter, sham-controlled,...
Remodeling of right coronary artery (RCA) occurs during ventricular hypertrophy (RVH) induced by banding the pulmonary (PA). The effect RVH on RCA endothelial function and reactive oxygen species (ROS) in vessel wall remains unclear. A swine model (n = 12 pigs) PA was used to study ROS level. To obtain longitudinal hemodynamic geometric data, digital subtraction angiography progression RVH. Blood flow increased 82% lumen diameter 22% over a 4-wk period increase blood commensurate resulted...
Mortality during follow-up after acute Type B aortic dissection is substantial with expansion observed in over 59% of the patients. Lumen pressure differential considered a prime contributing factor for dilation propagation. The objective study was to evaluate relationship between changes vessel geometry and without lumen post propagation an ex vivo porcine model comparison patient clinical data. A pulse duplicator system utilized propagate within descending thoracic vessels set proximal...
The pressure-diameter relation (PDR) and the wall strain of coronary blood vessels have important implications for flow arthrosclerosis, respectively. Previous studies shown that these mechanical quantities are significantly affected by axial stretch vessels. objective this study was to measure physiological in vasculature; i.e., from left anterior descending (LAD) artery tree sinus vein determine its effect on PDR hence stiffness. Silicone elastomer perfused through LAD trees cast at...
Transport of colonic content is a complex physiologic process through which contents are received from the ileum, solidify during passage, and finally expelled rectum anus.1Yamada T et al. (eds). Textbook Gastroenterology, 5th Edition. Blackwell, 2009. pp. 1717–1744.Google Scholar,2Gregersen H, Christensen J. Clinical mechanics in Gut. An Introduction. Bentham Publishers, 2016.Google Scholar Colonic motility transit difficult to study where mechanical loading motion need be quantified. Since...
This study aimed to assess the long-term effects of pulmonary artery denervation (PADN) on mortality in patients with arterial hypertension (PAH).Between March 2012 and 2018, a total 120 PAH, who underwent PADN treatment were prospectively followed up, analysed. Patients classified into World Health Organization (WHO) Functional Class I II (FC 1-2; n=46) III IV 3-4; n=74) according their FC prior PADN. The primary endpoint was lung transplantation-free until 2021. secondary change six-minute...
Long-term clinical outcomes after pulmonary artery denervation (PADN) in patients with Group 1 arterial hypertension (PAH) have not been reported.
Abstract Aim: Inherent fundamental difference exists among arteries of different sizes. The purpose this study was to evaluate the relation between regional wall shear stress (WSS) in various sizes and contents nitrite NO synthase (NOS) isoforms. Methods: Five conduit a wide range diameter (1–8 mm) were examined hind limbs 13 pigs. Blood flow rate outer measured vivo determine WSS. Arterial tissues harvested for measurement NOS protein contents. concentration nitrite, product synthesis,...
This study evaluated the prognostic value of remnant lipoprotein cholesterol (RLP-C) as a predictor in-stent restenosis (ISR) after drug-eluting stent (DES) implantation in patients with coronary artery disease (CAD). Consecutive CAD (n = 612) who underwent both successful DES and follow-up angiography ranging from 6 to 24 months were enrolled. The independent predictors ISR explored by multivariate logistic regression analysis; 95 (15.52%) identified have ISR. Multivariate analysis showed...
The zero-stress state of a blood vessel has been extensively studied because it is the reference for which all calculations intramural stress and strain must be based. It also found to reflect nonuniformity in growth remodeling response chemical or physical changes. can characterized by an opening angle, defined as angle subtended two radii connecting midpoint inner wall. All prior studies documented with no regard duration no-load state. Our hypotheses were that, given viscoelastic...
This study investigates the effect of local mechanical stimulation induced by pressure or flow-overload in right coronary artery (RCA) angiotensin II type 1 (AT1) receptor-mediated endothelial dysfunction swine models aortic pulmonary banding.A total 36 pigs (37 ± 7 kg) were studied. The RCA was exposed to pressure-overload banding (n = 6) blood for 4 weeks, and sham-operated animals served as controls 6). 18 acute ex-vivo pressure-overload. effects stimuli on AT1 receptor determined...
The use of endovascular treatment in the thoracic aorta has revolutionized clinical approach treating Stanford type B aortic dissection. endograft procedure is a minimally invasive alternative to traditional surgery for management complicated type-B patients. Endograft first deployed exclude proximal entry tear redirect blood flow towards true lumen and then stent/graft push intimal flap against false wall such that reconstituted by sealing lumen. Although reduced mortality rate patients...
Several technologies have been developed for assessing anorectal function including the act of defecation. We used a new prototype Fecobionics technology, multi-sensor simulated feces, to visualize defecatory patterns and introduced metrics physiology assessment in normal subjects. Fourteen subjects with fecal incontinence constipation questionnaire scores were studied. The 10-cm-long device provided measurements axial pressures, orientation, bending, shape. bag was distended...
The anti-aging function of Klotho gene has been implicated in age-related diseases. physiological importance the progression arterial stiffness with aging, however, remains unclear. goal this study is to determine correlation circulating early aortic stiffening and peripheral hemodynamics. We measured serum levels a group pigs age ranges 1.5-9 years investigated relationship between biomarkers including pulse wave velocity (PWV), augmentation index (AIx) pressure (PP). effects on vascular...
Thoracic endovascular aortic repair (TEVAR) has been widely adopted as a standard for treating complicated acute and high-risk uncomplicated Stanford Type-B dissections. The treatment redirects the blood flow towards true lumen by covering proximal dissection tear which promotes sealing of false lumen. Despite advances in TEVAR, over 30% patients require additional interventions. This is primarily due to presence persistent patent post-TEVAR that could potentially enlarge time. We propose...
Ganoderma atrum (G. atrum) have been used as medicinal and edible tonic in China for more than 2000 years, the sterol components of G. are crucial human health. This study aimed to investigate antioxidant potential, antimicrobial activity protective effect against Caco-2 cell oxidation damage compounds from vitro. Sterol were extracted its composition was analyzed by high performance liquid chromatography (HPLC), 7,22-ergodienone separated these compounds. The estimation potential evaluated...
COVID-19 has been sweeping the world since it emerged in late December 2019. However, little is known about cardiac injury hospitalised patients. This study to investigate incidence and characteristics of myocardial patients admitted hospital.Fifty-four were enrolled one ward Tongji Hospital, Wuhan, China, 5 excluded caused by missing troponin I levels. Forty-nine participants included final analysis. The clinical manifestations analysed. Patients divided into two groups, group non-cardiac...