A5059040089- Pulmonary Hypertension Research and Treatments
- Congenital Heart Disease Studies
- Cardiovascular Issues in Pregnancy
- Vascular Anomalies and Treatments
- Cardiovascular and Diving-Related Complications
- Heart Failure Treatment and Management
- Cardiovascular Function and Risk Factors
- Mechanical Circulatory Support Devices
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Tracheal and airway disorders
- Infective Endocarditis Diagnosis and Management
- Cardiovascular Conditions and Treatments
- Traumatic Brain Injury and Neurovascular Disturbances
- Cardiac Valve Diseases and Treatments
- Liver Disease and Transplantation
- Coronary Artery Anomalies
- Cerebrovascular and Carotid Artery Diseases
- Infant Nutrition and Health
- Migraine and Headache Studies
- Potassium and Related Disorders
- Human Mobility and Location-Based Analysis
- Pericarditis and Cardiac Tamponade
- Cardiovascular Health and Disease Prevention
- Restraint-Related Deaths
- Acute Myocardial Infarction Research
Wuhan Asia Heart Hospital
2015-2025
Zhongnan Hospital of Wuhan University
2022-2024
Wuhan University
2015-2024
South China Sea Institute Of Oceanology
2024
Wuhan University of Science and Technology
2019-2020
Rationale: Oral treprostinil improves exercise capacity in patients with pulmonary arterial hypertension (PAH), but the effect on clinical outcomes was unknown.Objectives: To evaluate of oral compared placebo time to first adjudicated worsening event participants PAH who recently began approved monotherapy.Methods: In this event-driven, double-blind study, we randomly allocated 690 (1:1 ratio) receive or extended-release tablets three times daily. Eligible were using monotherapy for over 30...
Background The transition of right ventricle (RV) from a compensated to decompensated state contributes survival in pulmonary arterial hypertension (PAH). This study investigates the significance atrial (RA) dysfunction on disease progression PAH. Methods Eighty patients with PAH, including 58 hemodynamically RV function (PAH-C) and 22 (PAH-D), were compared 80 age-matched sex-matched normal controls. RA longitudinal strain rate (SR) parameters corresponding reservoir (total ε s SR ),...
World Health Organization (WHO) group 1 pulmonary arterial hypertension (PAH) is a progressive, debilitating disease. Previous observational studies have demonstrated that artery denervation (PADN) reduces pressures in PAH. However, the safety and effectiveness of PADN not been established randomized trial. The aim this study was to determine treatment effects patients with Patients WHO PAH taking PAH-specific drugs for at least 30 days were enrolled multicenter, sham-controlled,...
Abstract Background and objective Nationally representative reports on the characteristics long‐term survival of pulmonary arterial hypertension (PAH) from developing countries are scarce. The applicability current main risk stratifications longitudinal changes in goal‐oriented treatments have yet to be elucidated real‐world settings. Therefore, we aimed provide insights into characteristics, PAH China explore our independent cohort. Methods patients were consecutively enrolled a national...
Abstract Objectives To report the 10-year survival rate and prognostic factors of pulmonary arterial hypertension associated with CTD (CTD-PAH) patients, to compare treatment between patients enrolled before after 2015, validate discrimination recommended four-strata model in predicting at follow-up Chinese CTD-PAH patients. Methods This study was derived from a national multicentre prospective registry 2009 2019. Medical records were collected baseline follow-up, including PAH-targeted...
This study aimed to assess the clinical characteristics and long-term survival outcome in patients with Takayasu's arteritis-associated pulmonary hypertension (TA-PH).We conducted a nationally representative cohort of TA-PH using data from National Rare Diseases Registry System China. Patients artery involvement who fulfilled diagnostic criteria arteritis were included. The primary was time diagnosis occurrence all-cause death. Between January 2007 2019, total 140 included, mean age 41.4...
Background The next-generation closure device for interventional treatment of patent foramen ovale (PFO) is regarded as biodegradable, yet the corresponding biomaterial technique still challenging. Herein, we report clinical application a novel biodegradable PFO occluder [made material polydioxanone (PDO)] that finally coming into use. Objectives This study aimed to assess safety and efficacy Pansy® (Mallow Medical, Shanghai, China) in patients exhibiting with substantial right-to-left shunt...
This is the first multicentre prospective registry reporting baseline characteristics and estimated survival of patients with chronic thromboembolic pulmonary hypertension (CTEPH) in China. A total 593 CTEPH were included. The long‐term rates are similar to those international Spanish registries. Pulmonary endarterectomy an independent predictor survival. See related Editorial
Severe/critical patients with coronavirus disease 2019 (COVID-19) have become the central issue in current global pandemic due to their high mortality rate. However, relationship between antibody response and clinical outcomes has not been well described this group. We conducted a single-center, retrospective, cohort study investigate serum immunoglobulin G (IgG) IgM severe/critical COVID-19. Seventy-nine COVID-19 admitted Wuhan Asia General Hospital Wuhan, China during January 22, 2020...
Soluble suppression of tumorigenicity 2 (sST2), a biomarker representing myocardial fibrosis and inflammation, has been applied in risk stratification patients with infarction (MI). However, whether primary PCI (PPCI) will eliminate the predictive value sST2 STEMI not well studied. Here, we conducted prospective clinical trial to evaluate correlation between prognosis undergoing PPCI. levels were measured 295 (60.2 ± 10.8 years) at admission using high sensitivity assay. Baseline...
Parameters of myocardial deformation may provide improved insights into right ventricular (RV) dysfunction. We quantified RV longitudinal function using a fast, semi-automated method and investigated its diagnostic prognostic values in patients with repaired tetralogy Fallot (rTOF) pulmonary arterial hypertension (PAH), who respectively exemplify volume pressure overload conditions. The study enrolled 150 (rTOF, n = 75; PAH, 75) 75 healthy controls. parameters interest were fast global...
Abstract The etiology of pulmonary arterial hypertension (PAH) is complex, especially the investigation rare pathogeny difficult. Congenital portosystemic venous shunt (CPSS) a congenital anomaly in which portal blood completely or partially bypasses liver through shunt, and drains directly into inferior vena cava (IVC) (Howard Davenport J Pediatr Surg 32:494–497, 1997).CPSS an uncommon cause PAH (Christiane et al. Gastroenterol Nutr 56:675–681, 2013), often covered by other pathogenic...
Abstract This study aimed to analyze the correlation between efficiency coefficient of right ventricular–pulmonary artery coupling ( η vv ) and prognosis patients with pulmonary arterial hypertension (PAH). A total 64 who underwent heart catheterization (RHC) were enrolled divided into PAH control groups depending on RHC results. Pressure volumetric methods adopted results cardiac magnetic resonance imaging examination. The in 2 calculated, relationship calculated by 2-year was evaluated....
Pulmonary hypertension is a chronic disease developing progressively with high mortality. patients need persistent medical care; however, limited reports focused on them when there was an outbreak of coronavirus 2019 in China. This national survey aimed to evaluate the overall condition pulmonary during this period. A questionnaire regarding living designed by diagnostic experts Wuhan Asia Heart Hospital. and their family members were invited participate online. One‐hundred twenty 23...
This study aimed to assess the long-term effects of pulmonary artery denervation (PADN) on mortality in patients with arterial hypertension (PAH).Between March 2012 and 2018, a total 120 PAH, who underwent PADN treatment were prospectively followed up, analysed. Patients classified into World Health Organization (WHO) Functional Class I II (FC 1-2; n=46) III IV 3-4; n=74) according their FC prior PADN. The primary endpoint was lung transplantation-free until 2021. secondary change six-minute...
Agitated saline (AS) with blood has been shown to have good tolerance and increased efficacy when used in contrast-enhanced transcranial Doppler (c-TCD) detect right-to-left shunt (RLS). However, little is known about the effects of volume on c-TCD results. Our study investigated characterization AS different volumes vitro compared results vivo.In vitro, without blood, 5% (5% BAS), 10% (10% BAS) were prepared based previous studies observed under microscopy. The numbers sizes microbubbles...
Long-term clinical outcomes after pulmonary artery denervation (PADN) in patients with Group 1 arterial hypertension (PAH) have not been reported.
Abstract Introduction Current guidelines emphasize that accurate risk stratification is important for patients with pulmonary arterial hypertension (PAH), however, few suggestions have been specified PAH associated congenital heart disease (PAH‐CHD). Objectives The aim of this study was to propose an and simple system based on current in PAH‐CHD during 12‐month follow‐up. Methods We reviewed 288 Chinese between January 2014 December 2016 retrospective cohort study. low‐risk criteria...