A5086668788- Traditional Chinese Medicine Studies
- Plant-based Medicinal Research
- Heart Failure Treatment and Management
- Atrial Fibrillation Management and Outcomes
- Cardiovascular Function and Risk Factors
- Traditional Chinese Medicine Analysis
- Venous Thromboembolism Diagnosis and Management
- Cardiovascular and exercise physiology
- Cardiac Fibrosis and Remodeling
- Heart Rate Variability and Autonomic Control
- Mobile Health and mHealth Applications
- Bone fractures and treatments
- NF-κB Signaling Pathways
- Technology Use by Older Adults
- Cardiac Health and Mental Health
- Urological Disorders and Treatments
- Genital Health and Disease
- Biomedical Ethics and Regulation
- Blood Pressure and Hypertension Studies
- Health disparities and outcomes
- Autophagy in Disease and Therapy
- Ginkgo biloba and Cashew Applications
- MicroRNA in disease regulation
- Pharmacovigilance and Adverse Drug Reactions
- Medicinal Plants and Bioactive Compounds
First Affiliated Hospital of Guangzhou University of Chinese Medicine
2016-2025
Guangzhou University of Chinese Medicine
2020-2024
Technical University of Munich
2019
China Academy of Chinese Medical Sciences
2014
First Bethune Hospital of Jilin University
1997
Beijing Tian Tan Hospital
1995
Abstract Background Myocardial infarction (MI) poses a global public health challenge, often associated with elevated mortality rates and grim prognosis. A crucial aspect of the inflammatory injury healing process post-MI involves dynamic differentiation macrophages. promising strategy to alleviate myocardial damage after MI is by modulating response orchestrating shift from pro-inflammatory (M1) anti-inflammatory (M2) macrophages, aiming achieve reduced M1/M2 ratio. Nuanxinkang (NXK),...
Atherosclerosis is characterised by lipid accumulation and formation of foam cells in arterial walls. Dysregulated autophagy a crucial factor atherosclerosis development. The significance microRNA (miR)-125b-1-3p cardiovascular disease well-established; however, its precise role regulating impact on vascular smooth muscle (VSMCs) remain unclear. Here, we observed reduced autophagic activity decreased miR-125b expression during progression. miR-125b-1-3p overexpression significantly...
ABSTRACT SC1011 (sufenidone) is a novel pyridone derivative with therapeutic potential for idiopathic pulmonary fibrosis (IPF). Two Phase 1 studies evaluated the safety and pharmacokinetics of single (SAD) multiple ascending doses (MAD) immediate‐release (IR) modified‐release (MR) oral formulations in healthy adult subjects. In 1a, subjects were randomized to receive IR or placebo SAD (50 mg‐300 mg) MAD (100 mg 200 twice daily 7 days. The 1b study consisted three treatment groups that...
Pressure overload has an important role in heart failure, inducing excessive autophagy cardiac myocytes that is considered to be pathogenic. Resveratrol been reported improve dysfunction induced by pressure overload, but it unclear whether resveratrol ameliorates regulating autophagy. In this study, failure was rats constriction of the abdominal aorta. Four weeks after surgery, with were randomized treatment (8 mg·kg−1·d−1 intraperitoneal injection) for 28 days or injection vehicle...
Traditional Chinese medicine(TCM) preparations in medical institutions, as a unique and important form of China, have long history human use serve bridge between clinical experience prescriptions new medicine preparations. The state encourages institutions to transform their into traditional medicines, emphasizing role "incubators". Since the proposal registration evaluation evidence system with integration TCM theory, experience(HUE), experience, idea transforming used drugs based...
This study aimed to systematically evaluate the effectiveness and safety of Tanreqing Injection in treatment severe pneumonia elderly. Eighteen randomized controlled trials(RCTs) involving 1 457 elderly patients with were included after conducting searches both Chinese English databases as well clinical trial registration platforms. The quality studies was assessed using Cochrane risk bias assessment tool. Meta-analysis conducted RevMan 5.4 Stata 17 software, sequential analysis(TSA)...
Intrinsic capacity (IC), as a comprehensive measure of an individual's functional ability, has gained prominence in the framework for healthy aging introduced by World Health Organization (WHO). As internet usage continues to integrate into daily life, it is imperative scrutinize association between use and IC effectively promote among middle-aged older population.
The evaluation of the effectiveness traditional Chinese medicine(TCM) has long been a "bottleneck" issue that restricts healthy development and internationalization TCM. This article systematically analyzes differences in diagnostic treatment principles, material composition, new drug pathways, efficacy cognition, methodology between Western medicine from underlying logic medical perspective. On this basis, it integrates evidence elements clinical experience, experimental research,...
Patients with heart disease often suffer from ischemia, which can be treated by reperfusion. However, this treatment lead to the development of ischemia/reperfusion (I/R) injury, an inflammatory condition that cause further damage. Dexmedetomidine (Dex), α2-adrenoceptor agonist, and microRNA (miR)-17-3p, have both been suggested alleviate I/R injury cardiac tissue inflammation. The aim present study was investigate whether Dex miR-17-3p could act together prevent injury. H9C2 cells, a...
Background Coronary heart disease(CHD) with stable angina pectoris is a common cardiovascular disease. It has been reported that 10%–81.4% of these patients suffer from psychological conditions,such as depression, which associated more frequent angina, lower treatment satisfaction and perceived quality life. Ginkgo biloba extract (GBE), the raw material dropping pills (GBDPs), widely used to treat various conditions, including disease, ischaemic cerebrovascular depression. This clinical...
The human use experience of traditional Chinese medicine(TCM) is great significance for the development new medicine. In 2023, National Medical Products Administration(NMPA) issued Special Regulations on Registration Management Traditional Medicine, which explicitly encouraged conduct high-quality research TCM clinical practice to obtain sufficient evidence registration support. It also required that should comply with relevant requirements and undergo verification. quality directly...
Background: Heart failure (HF) is a serious and terminal stage of various cardiac diseases the most common complication coronary heart disease (CHD). Previous clinical studies have shown that Qishen Yiqi dropping pills (QSYQ) effect treating chronic failure. This study aims to evaluate efficacy, safety optimal effective dose QSYQ in CHD complicating HF with reduced ejection fraction (HFrEF). Methods: We will conduct randomized, double-blind, placebo controlled, multicenter trial. A total 228...
Introduction Unstable angina (UA), referred to as acute coronary syndrome (ACS), causes unexpected chest pain. Xueshuantong injection (lyophilised) (XST) is a traditional Chinese herbal having the potential treat ACS. However, no clinical trial has been performed in this field. This aims examine efficacy and safety of XST. Methods analysis randomised, parallel-arm, controlled, double-blind multicentre trial. A total 1200 participants with UA will be enrolled 1:1 ratio, 600 patients included...
We present the case of a 28 year old patient with an incomplete tear tunica albuginea occurred after having sexual intercourse in female superior position. The diagnostic assessment was performed first clinically, then CT, owing to its high resolution, allowed exactly detect location leading precise preoperative planning. After adequate diagnosis through imaging and proper planning, selective minimally invasive surgical approach repair lesion. had good erection no angular deformity or plaque...
Since "the implementation of good clinical practice"(GCP), especially after 2015, the overall quality new drug cli-nical trials in China has made significant progress, but compared with developed countries, there are still some obvious problems China. Clinical drugs traditional Chinese medicine an important part In addition to common all trials, also special problems. terms security data, such as collection human safety data is not standardized, management and judgment unexpected...
The relevant laws and regulations of drug clinical trials were introduced in this paper. It is pointed out that with re-gulatory technological advances, have become an important link the development new drugs traditional Chinese medicines(TCM). Clinical TCM must comply requirement Good Practice for Trial on Medicinal Products. In view particularities TCM, China has established ethical review system research carried certification research. order to guide departments promulgated a series...