A5102851293- Coronary Interventions and Diagnostics
- Lipoproteins and Cardiovascular Health
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiac Imaging and Diagnostics
- Peripheral Artery Disease Management
- Pharmaceutical Economics and Policy
- Vascular Procedures and Complications
- Acute Myocardial Infarction Research
- Cardiac Valve Diseases and Treatments
- Atrial Fibrillation Management and Outcomes
- Cancer, Lipids, and Metabolism
- Health Systems, Economic Evaluations, Quality of Life
- Venous Thromboembolism Diagnosis and Management
- Cardiac pacing and defibrillation studies
- Cardiac Arrhythmias and Treatments
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cardiovascular Function and Risk Factors
- Infective Endocarditis Diagnosis and Management
- Cardiac, Anesthesia and Surgical Outcomes
- Cerebrovascular and Carotid Artery Diseases
- Gastrointestinal Tumor Research and Treatment
- Cardiomyopathy and Myosin Studies
- Image and Signal Denoising Methods
- Pulmonary Hypertension Research and Treatments
- Diabetic Foot Ulcer Assessment and Management
Yonsei University
2015-2025
Gangnam Severance Hospital
2015-2025
Severance Hospital
2015-2024
Lodestar Research Corporation (United States)
2023
Gyeongsang National University
2021
Yonsei University Health System
2014
BACKGROUND: Stopping aspirin within 1 month after implantation of a drug-eluting stent for ticagrelor monotherapy has not been exclusively evaluated patients with acute coronary syndrome. The aim this study was to investigate whether <1 dual antiplatelet therapy (DAPT) is noninferior 12 months ticagrelor-based DAPT adverse cardiovascular and bleeding events in METHODS: In randomized, open-label, noninferiority trial, 2850 syndrome who underwent at 24 centers South Korea were randomly...
In patients with coronary artery disease, some guidelines recommend initial statin treatment high-intensity statins to achieve at least a 50% reduction in low-density lipoprotein cholesterol (LDL-C). An alternative approach is begin moderate-intensity and titrate specific LDL-C goal. These alternatives have not been compared head-to-head clinical trial involving known disease.To assess whether treat-to-target strategy noninferior of for long-term outcomes disease.A randomized, multicenter,...
Abstract Background and Aims Drug-coated balloons (DCBs) have demonstrated favourable outcomes following endovascular therapy for femoropopliteal artery (FPA) disease. However, uncertainty remains whether the use of intravascular ultrasound (IVUS) can improve DCBs. Methods This prospective, multicentre, randomized trial, conducted at seven centres in South Korea, compared IVUS-guided vs. angiography-guided angioplasty treating FPA disease with Patients were assigned to receive (n = 119) or...
Abstract Aims This study evaluated the effect of moderate-intensity statin with ezetimibe combination therapy vs. high-intensity monotherapy among patients diabetes mellitus (DM) and atherosclerotic cardiovascular disease (ASCVD). Methods results was a pre-specified, stratified subgroup analysis DM cohort in RACING trial. The primary outcome 3-year composite death, major events, or non-fatal stroke. Among total patients, 1398 (37.0%) had at baseline. incidence 10.0% 11.3% randomized to...
To compare the long term efficacy and safety of rosuvastatin with atorvastatin treatment in adults coronary artery disease.Randomised, open label, multicentre trial.12 hospitals South Korea, September 2016 to November 2019.4400 (age ≥19 years) disease.Participants were assigned receive either (n=2204) or (n=2196) using 2×2 factorial randomisation.The primary outcome was a three year composite all cause death, myocardial infarction, stroke, any revascularisation. Secondary outcomes endpoints:...
Recent studies have reported improved diastolic function in patients administered sodium-glucose cotransporter 2 inhibitors (SGLT2i). We aimed to investigate the effect of dapagliflozin on left ventricular (LV) a diabetic animal model and determine molecular cellular mechanisms underlying its function.A total 30 male New Zealand white rabbits were randomized into control, diabetes, or diabetes+dapagliflozin groups (n = 10/per each group). Diabetes was induced by intravenous alloxan. Cardiac...
Identifying patients with high bleeding risk (HBR) is important when making decisions for antiplatelet therapy strategy. This study evaluated the impact of ticagrelor monotherapy after 3-month dual (DAPT) according to HBR in acute coronary syndrome (ACS) treated drug eluting stents (DESs).In this post-hoc analysis TICO trial, was defined by 2 approaches: meeting Academic Research Consortium (ARC-HBR) criteria or Predicting Bleeding Complications Patients Undergoing Stent Implantation and...
High-intensity statin is strongly recommended in patients at very high risk (VHR) of atherosclerotic cardiovascular disease (ASCVD). However, concerns about statin-associated adverse effects result underuse this strategy practice.
The popliteal artery is generally regarded as a "no-stent zone." Limited data are available on the outcomes of drug-coated balloons (DCBs) for disease. This study aimed to evaluate 12-month clinical among patients who received DCB treatment atherosclerotic prospective, multicenter registry enrolled 100 from 7 Korean endovascular centers underwent therapy using IN.PACT (Medtronic) symptomatic primary endpoint was patency and secondary clinically driven target lesion revascularization...
Background: In patients with acute coronary syndrome (ACS) a high risk of ischemia, the impact ticagrelor monotherapy after short-term dual antiplatelet therapy (DAPT) has not been clearly elucidated. Methods: This post hoc analysis TICO trial (Ticagrelor Monotherapy After 3 Months in Patients Treated With New Generation Sirolimus-Eluting Stent for Acute Coronary Syndrome) compared 3-month DAPT versus ticagrelor-based 12-month high-ischemic ACS, defined as any following: number stents...
Background: There are 2 competing approaches to optimize drug-eluting stent implantation: angiography-guided routine postdilation or intravascular ultrasound (IVUS) guidance. Methods: From the pooled data of randomized trials, IVUS-XPL (Impact Intravascular Ultrasound Guidance on Outcomes Xience Prime Stents in Long Lesions) and ULTIMATE (Intravascular Guided Drug Eluting Implantation All-Comers Coronary Lesions), that compared IVUS- versus implantation, we 1037 patients (1265 lesions) with...
Abstract Regarding stent expansion indices, previous optical coherence tomography (OCT) studies have shown minimal area (MSA) to be most predictive of adverse events. We sought evaluate the impact various and apposition indices by post-stent OCT on clinical outcomes find OCT-defined optimal implantation criteria. A total 1071 patients with 1123 native coronary artery lesions treated new-generation drug-eluting stents guidance final analysis were included. Several (MSA, MSA/average reference...
Background: We sought to explore the sex differences in clinical outcomes among patients with acute coronary syndrome treated ticagrelor monotherapy after ticagrelor-based 3-month versus 12-month dual-antiplatelet therapy. Methods: This was a post hoc analysis of TICO trial (Ticagrelor Monotherapy After 3 Months Patients Treated With New Generation Sirolimus-Eluting Stent for Acute Coronary Syndrome; n=3056)—a randomized controlled drug-eluting stent. The primary outcome net adverse event...
Background: Although stent underexpansion on intravascular ultrasound (IVUS) has been a major predictor for adverse outcomes in previous studies, these studies have primarily focused angiographic restenosis or repeat revascularization with short-term follow-up. This study sought to evaluate the long-term benefit of different criteria IVUS-defined optimal expansion hard clinical outcomes. Methods: From pooled data 2 randomized trials, IVUS-XPL (Impact Intravascular Ultrasound Guidance...