A5048651693- Antiplatelet Therapy and Cardiovascular Diseases
- Acute Myocardial Infarction Research
- Coronary Interventions and Diagnostics
- Venous Thromboembolism Diagnosis and Management
- Lipoproteins and Cardiovascular Health
- Cardiac Imaging and Diagnostics
- Atrial Fibrillation Management and Outcomes
- Inflammatory mediators and NSAID effects
- Cardiac, Anesthesia and Surgical Outcomes
- Heart Failure Treatment and Management
- Cardiovascular Function and Risk Factors
- Diabetes Treatment and Management
- Peripheral Artery Disease Management
- Cardiac Structural Anomalies and Repair
- Cardiovascular Health and Disease Prevention
- Cardiac electrophysiology and arrhythmias
- Cardiac Arrhythmias and Treatments
- Cardiac Arrest and Resuscitation
- Analytical Methods in Pharmaceuticals
- Synthesis of β-Lactam Compounds
- Platelet Disorders and Treatments
- Cardiovascular Effects of Exercise
- Respiratory Support and Mechanisms
- Cardiac and Coronary Surgery Techniques
- Pain Management and Treatment
Gyeongsang National University
2016-2025
Gyeongsang National University Hospital
2014-2025
Changwon National University
2016-2024
Inje University Ilsan Paik Hospital
2023
Florida College
2015-2019
University of Florida
2015-2019
Seoul National University Hospital
2011
University of Ulsan
2010
Asan Medical Center
2010
Ulsan College
2010
Background— As compared with whites, East Asians more often carry the cytochrome P450 ( CYP ) 2C19 loss-of-function (LOF) allele CYP2C19*3 variant. The influence of CYP2C19 LOF alleles *2 and *3 on clopidogrel response clinical outcomes in acute myocardial infarction (AMI) has not been reported. We sought to evaluate effect variants pharmacodynamics long-term prognosis these patients. Methods Results— Patients who survived an AMI (n=266) were enrolled a single-center registry. Predischarge...
Platelet inhibitory effects induced by oral P2Y12 receptor antagonists are delayed in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PPCI), which may be attributed to impaired absorption affecting drug pharmacokinetics (PK) and pharmacodynamics (PD). Crushing tablets has been suggested lead more favorable PK/PD profiles. To date, no studies have investigated the of crushing prasugrel.This study sought determine whether...
Abstract Aims This study evaluated the effect of moderate-intensity statin with ezetimibe combination therapy vs. high-intensity monotherapy among patients diabetes mellitus (DM) and atherosclerotic cardiovascular disease (ASCVD). Methods results was a pre-specified, stratified subgroup analysis DM cohort in RACING trial. The primary outcome 3-year composite death, major events, or non-fatal stroke. Among total patients, 1398 (37.0%) had at baseline. incidence 10.0% 11.3% randomized to...
Atherothrombotic events are influenced by systemic hypercoagulability and fibrinolytic activity. The present study evaluated thrombogenicity indices their prognostic implications according to disease acuity.From the consecutive patients undergoing percutaneous coronary intervention (PCI), those with (n = 2705) were grouped acuity [acute myocardial infarction (AMI) vs. non-AMI]. Thrombogenicity measured thromboelastography (TEG). Blood samples for TEG obtained immediately after insertion of...
The Genoss paclitaxel-coated balloon (PCB) is a novel PCB with shellac and vitamin E as excipients, enhancing drug delivery to the target lesion minimizing restenosis. This study aimed compare quantitative coronary angiographic outcomes at 6 months after treatment of de novo artery disease (CAD) 2 different types PCBs. prospective, multicenter, noninferiority trial randomized 204 patients chronic syndrome or stabilized acute E-based reference (SeQuent Please NEO) in 1:1 ratio. primary...
Optimal platelet inhibition is an important therapeutic adjunct in patients acute myocardial infarction (AMI) undergoing coronary stenting. Whether adjunctive cilostazol to dual antiplatelet therapy (triple therapy) can inhibit enhanced reactivity with AMI yet has not been determined. The aim of this study was assess the degree by triple AMI.Immediately after emergency room arrival, received clopidogrel (600-mg loading dose, followed 75 mg daily) and aspirin (300-mg dose 200 daily throughout...
<h3>Background</h3> Although East Asians carry the cytochrome P450 (CYP) <i>2C19*2</i> allele more frequently than do Caucasians, impact of <i>CYP2C19*2</i> on clopidogrel pharmacodynamics and clinical outcomes is unknown. <h3>Objective</h3> To evaluate effect <i>CYP2C19</i> variants long-term prognosis in Asian patients with drug-eluting stents (DES). <h3>Methods</h3> DES-treated taking dual antiplatelet therapy were enrolled from a Korean multicentre genetic registry. The was genotyped...
<h3>Objectives</h3> We conducted a randomised, double blind, placebo controlled trial to assess the efficacy and safety of cilostazol, selective inhibitor phosphodiesterase 3, in patients with vasospastic angina (VSA). <h3>Background</h3> Cilostazol has been shown induce vascular dilatation, but its VSA is unknown. <h3>Methods</h3> Between October 2011 July 2012, 50 confirmed who had ≥1 episodes/week despite amlodipine therapy (5 mg/day) were randomly assigned receive either cilostazol (up...
Abstract Background The aim of this study is to determine whether there correlation between endothelial function and skeletal muscle measured by hand grip strength in elderly women. Methods This cross‐sectional used data NAMGARAM‐2 cohort. cohort consisted a group people living three rural communities. They were enrolled for studies on activity limitation due age‐related musculoskeletal disorders including knee osteoarthritis, osteoporosis, sarcopenia. residents aged 40 years or older....
Data on drug-coated balloon (DCB) treatment in the context of diabetes mellitus (DM) and multivessel coronary artery disease (CAD) are limited. We aimed to investigate clinical impact DCB-based revascularization percutaneous intervention (PCI) patients with DM CAD.A total 254 (104 DM) successfully treated DCB alone or combined drug-eluting stent (DES) were retrospectively enrolled (DCB-based group) compared propensity-matched second-generation DES from PTRG-DES registry (n = 13,160 patients)...
High-intensity statin is strongly recommended in patients at very high risk (VHR) of atherosclerotic cardiovascular disease (ASCVD). However, concerns about statin-associated adverse effects result underuse this strategy practice.
Abstract Background and Aims Platelet-fibrin clot strength (PFCS) is linked to major adverse cardiovascular event (MACE) risk. However, the association between PFCS platelet reactivity their prognostic implication remains uncertain in patients undergoing percutaneous coronary intervention (PCI). Methods In PCI-treated (n = 2512) from registry data January 2010 November 2018 South Korea, using thromboelastography VerifyNow were measured. High (PFCSHigh) was defined as maximal amplitude ≥ 68...
Abstract Compared with Caucasian patients, East Asian patients have the unique risk–benefit trade-off and different responsiveness to antithrombotic regimens. The aim of this study was compare pharmacodynamic profile in acute coronary syndromes (ACSs) treated prasugrel standard-dose versus a de-escalation strategy. Before discharge, ACS age <75 years or weight ≥60 kg (n = 255) were randomly assigned (10-mg group) strategy (5-mg group platelet function test [PFT]-guided group). After 1...