A5076888500- Antiplatelet Therapy and Cardiovascular Diseases
- Coronary Interventions and Diagnostics
- Acute Myocardial Infarction Research
- Cardiac Imaging and Diagnostics
- Cardiovascular Function and Risk Factors
- Venous Thromboembolism Diagnosis and Management
- Lipoproteins and Cardiovascular Health
- Atrial Fibrillation Management and Outcomes
- Cerebrovascular and Carotid Artery Diseases
- Cardiac Valve Diseases and Treatments
- Vascular Procedures and Complications
- Diabetes Treatment and Management
- Cardiovascular Disease and Adiposity
- Peripheral Artery Disease Management
- Advanced MRI Techniques and Applications
- Kawasaki Disease and Coronary Complications
- Cardiac Arrest and Resuscitation
- Colorectal Cancer Surgical Treatments
- Aortic Disease and Treatment Approaches
- Coronary Artery Anomalies
- Central Venous Catheters and Hemodialysis
- Blood Pressure and Hypertension Studies
- Cardiovascular Health and Disease Prevention
- Cardiac, Anesthesia and Surgical Outcomes
- Infective Endocarditis Diagnosis and Management
Hallym University Kangnam Sacred Heart Hospital
2016-2025
Hallym University
2012-2025
Hallym University Medical Center
2009-2023
Dankook University Hospital
2022
Weatherford College
2021
Seoul National University
2020
Yonsei University
2001-2016
Florida College
2013-2016
University of Florida
2013-2016
Jungheinrich (Germany)
2015
Background: Patients with diabetes mellitus (DM) are at increased risk of atherothrombotic events, underscoring the importance effective platelet inhibiting therapies. Prasugrel and ticagrelor reduce thrombotic complications to a greater extent than clopidogrel. Subgroup analyses pivotal clinical trials testing prasugrel versus clopidogrel showed DM patients have benefits that were consistent overall trial populations, although magnitude ischemic reduction appeared be enhanced prasugrel....
Pharmacodynamic (PD) studies comparing prasugrel and ticagrelor have reached inconsistent findings. Therefore, a comprehensive investigation the PD effects of vs. after switching from clopidogrel therapy, exploring both loading dose (LD) maintenance (MD) regimens represented aim this study. Patients (n = 110) with coronary artery disease were randomized to (60 mg LD/10 MD q.d.) or (180 LD/90 b.i.d) therapy for 1 week. assessments conducted using three assays (vasodilator-stimulated...
Data on drug-coated balloon (DCB) treatment in the context of diabetes mellitus (DM) and multivessel coronary artery disease (CAD) are limited. We aimed to investigate clinical impact DCB-based revascularization percutaneous intervention (PCI) patients with DM CAD.A total 254 (104 DM) successfully treated DCB alone or combined drug-eluting stent (DES) were retrospectively enrolled (DCB-based group) compared propensity-matched second-generation DES from PTRG-DES registry (n = 13,160 patients)...
The action of β-secretase (BACE1) is strongly correlated with the onset Alzheimer’s disease (AD). Aminochalcone derivatives were examined for their ability to inhibit BACE1. Parent aminochalcones showed two digit micromolar IC50s against Potency was enhanced 10-fold or more by introducing benzenesulfonyl amino group: 1 (IC50 = 48.2 μM) versus 4a 1.44 and 2 17.7 5a 0.21 μM). activity significantly influenced position number hydroxyl groups on chalcone B-ring: 3,4-dihydroxy > 4-hydroxy...
From May through July 2015, a total of 26 cases Middle East Respiratory Syndrome were reported from 2 hospitals in Daejeon, South Korea, including 1 index case and 25 new cases. We examined the epidemiologic features these found an estimated median incubation period 6.1 days (8.8 hospital A 4.6 B). The overall attack rate was 3.7% (4.7% 3.0% B), rates among inpatients caregivers same ward 12.3% 22.5%, respectively. case-fatality 44.0% (28.6% 63.6% use cohort quarantine may have played role...
Abstract This study evaluated the association of atherogenic index plasma (AIP) with platelet reactivity and clinical outcomes according to acute myocardial infarction (AMI). The composite 3-year adverse all-cause death, infarction, cerebrovascular accident was in 10,735 patients after successful percutaneous coronary intervention drug-eluting stents. AIP defined as base 10 logarithm ratio triglyceride high-density lipoprotein cholesterol concentration. High (HPR) ≥ 252 P2Y12 unit. An...
The purpose of the present study was to investigate whether multidetector computed tomography (MDCT) can identify nature chronic total occlusion (CTO) plaque, which cannot be measured quantitatively using traditional coronary angiography, and predict success percutaneous intervention (PCI).MDCT 3-dimensional volumetric radiologic density analysis performed for 186 consecutive CTO lesions. Plaque characteristics were determined Hounsfield units (HU) image voxels. remodeling index decreased...
Delayed enhancement (DE) on cardiac magnetic resonance imaging (CMR) is a marker of myocardial fibrosis. The absence DE in CMR predictor left ventricular (LV) functional improvement patients with non-ischemic cardiomyopathy (NICM), so the present study it was investigated whether presence has prognostic significance NICM at long-term follow-up.The 79 (56.4+/-13.5 years, 48 males) (LV ejection fraction <35%, no significant coronary artery disease) were monitored for occurrence events....
There is growing interest in understanding the effects of adding an oral anticoagulant patients on dual antiplatelet therapy (DAPT). Vitamin K antagonists (VKAs) and clopidogrel represent most broadly utilised P2Y12 receptor inhibitor, respectively. However, VKAs can interfere with metabolism via cytochrome P450 (CYP) system which turn may result increase platelet reactivity. Dabigatran a direct acting (anti-II) does not CYP has favourable safety efficacy profiles compared VKAs. The...
Aberrant vascular smooth muscle cell (VSMC) proliferation and migration are a major pathological phenomenon in disease characterized by intimal thickening. The important role of the mammalian target rapamycin (mTOR) signaling VSMC has been previously reported. Consequen tly, down-regulation mTOR pathway may be an effective way controlling excessive proliferation. Since microRNAs (miRNA) newly emerging regulators virtually all biological processes including cellular proliferation, miRNAs...
Background: The long-term effects of radical resection on quality life may influence the treatment selection. objective this study was to compare after sphincter preservation surgery or abdominoperineal for low rectal cancer.Methods: This prospective, cohort included patients who underwent cancer. primary outcomes were EORTC QLQ-C30 and CR38 quality-of-life scores 3 years surgery, which compared with linear generalised estimating equations, adjustment baseline values, a time effect, an...