A5085649267- Periodontal Regeneration and Treatments
- Atherosclerosis and Cardiovascular Diseases
- Mesenchymal stem cell research
- Coronary Interventions and Diagnostics
- Helicobacter pylori-related gastroenterology studies
- Anesthesia and Pain Management
- Adipokines, Inflammation, and Metabolic Diseases
- Bone fractures and treatments
- Electrospun Nanofibers in Biomedical Applications
- Glycosylation and Glycoproteins Research
- Oral and Maxillofacial Pathology
- Diabetes Treatment and Management
- Tissue Engineering and Regenerative Medicine
- Osteoarthritis Treatment and Mechanisms
- Cardiovascular Function and Risk Factors
- Muscle Physiology and Disorders
- Liver Disease and Transplantation
- ATP Synthase and ATPases Research
- Pediatric Hepatobiliary Diseases and Treatments
- Liver Disease Diagnosis and Treatment
- Lipoproteins and Cardiovascular Health
- Head and Neck Surgical Oncology
- Organ Transplantation Techniques and Outcomes
- Transgenic Plants and Applications
- Bone Metabolism and Diseases
Yonsei University
2016-2023
Cardiovascular Research Center
2016
Kyungpook National University
2009-2014
Kyung Hee University
2013
Yeungnam University
2010-2011
Yeungnam University College
2010
Yeungnam University Medical Center
2009
We sought to investigate an anti-atherosclerotic and anti-inflammatory effect of sodium-glucose cotransporter-2 (SGLT-2) inhibitors in normoglycemic atherosclerotic rabbit model.Male New Zealand white rabbits (n=26) were fed with a 1% high-cholesterol diet for 7 weeks followed by normal 2 weeks. After balloon catheter injury, the administered Dapagliflozin (1mg/kg/day) or control-medium 8 (n=13 each group). All lesions assessed angiography, optical coherence tomography (OCT), histological...
Recent studies have reported improved diastolic function in patients administered sodium-glucose cotransporter 2 inhibitors (SGLT2i). We aimed to investigate the effect of dapagliflozin on left ventricular (LV) a diabetic animal model and determine molecular cellular mechanisms underlying its function.A total 30 male New Zealand white rabbits were randomized into control, diabetes, or diabetes+dapagliflozin groups (n = 10/per each group). Diabetes was induced by intravenous alloxan. Cardiac...
Systemic transplantation of adipose-derived stem cells (ASCs) is emerging as a novel therapeutic option for functional recovery diverse damaged tissues. This study investigated the effects systemic human ASCs (hASCs) on bone repair. We found that hASCs secrete various cell-activating factors, including hepatocyte growth factor and extracellular matrix proteins. into ovariectomized mice induced an increased number both osteoblasts osteoclasts in tissue thereby prevented loss. also observed...
Senescence marker protein 30 (SMP30), an important aging molecule that is highly expressed in the liver, has been known to protect hepatocytes from apoptosis by synthesis of vitamin C. To explore function SMP30 liver fibrosis, effect deficiency on fibrosis was investigated knockout (KO) mice. Moreover, vivo results were further confirmed way hepatic stellate cell (HSC) isolation. We demonstrated carbon tetrachloride (CCl4)-induced and nuclear translocation p-Smad2/3, immediate downstream...
Despite the susceptibility to frequent intrinsic and extrinsic injuries, especially in inner zone, meniscus does not heal spontaneously owing its poor vascularity. In this study, effect of platelet-rich plasma (PRP), containing various growth factors, on meniscal mechanisms was examined under normal post-traumatic inflammatory conditions. Isolated primary cells New Zealand white (NZW) rabbits were incubated for 3, 10, 14 21 days with PRP(−), 10% PRP (PRP(+)), IL(+) or IL(+)PRP(+). The...
Aims Atherosclerosis is a well-known cause of cardiovascular disease and associated with variety inflammatory reactions. However, an adequate large-animal model advanced plaques to investigate the pathophysiology atherosclerosis lacking. Therefore, we developed assessed swine atherosclerotic macrophage polarization. Methods Mini-pigs were fed 2% high-cholesterol diet for 7 weeks followed by withdrawal periods 4 weeks. Endothelial denudation was performed using balloon catheter on 32 coronary...
Horse health has become a major concern with the expansion of horse-related industries and sports; importance healthy muscles for horse performance daily activities is undisputed. Here we generated equine-induced pluripotent stem cells (E-iPSCs) by reprogramming equine adipose-derived (E-ADSCs) into iPSCs using polycistronic lentiviral vector encoding four transcription factors (i.e., Oct4, Sox2, Klf4, c-Myc) then examined their characteristics. Subsequently, established E-iPSCs were...
Aim Although the atheroprotective effects of statins and angiotensin II receptor blockers (ARBs) are well-established, little is known about their additive effects, especially during early period atherosclerosis. The aim this study was to investigate whether combination a statin an ARB exerts synergistic anti-atherosclerotic elucidate mechanisms combined effects. Methods Atherosclerotic plaques were developed in arteries 23 rabbits using high-cholesterol diet (HCD) intra-arterial balloon...
Abstract Several mammals, including dogs, have been successfully cloned using somatic cell nuclear transfer (SCNT), but the efficiency of generating normal, live offspring is relatively low. Although high failure rate has attributed to incomplete reprogramming nuclei during cloning process, exact cause not fully known. To elucidate death in offspring, 12 deceased by SCNT were necropsied. The clones either stillborn just prior delivery or died with dyspnea shortly after birth. On gross...
A 4-year-old, male, dachshund was referred to a certain local veterinary hospital because of soft and fluctuant swelling in the left upper cervical region. The surgically removed appeared be filled with bloody mucus. Grossly, identified as salivary mucocele showed small multifocal whitish ossified tissue on its surface. Microscopically, wall granulation surrounding mucin, which composed loose edematous vascularized connective containing chronic inflammatory cells such lymphocytes, plasma...
Appropriate animal models of atherosclerotic plaque are crucial to investigating the pathophysiology atherosclerosis, as well for evaluation efficacy and safety vascular devices. We aimed develop a novel model that would be suitable study advanced lesions in vivo. Atherosclerotic was induced 24 iliac arteries from 12 rabbits by combining high cholesterol diet, endothelial denudation, injection into vessel wall with either saline (n=5), olive oil (n=6), or inflammatory proteins [n=13,...
Although there are growing demands for stem cell-based therapy companion animals in various diseases, a few clinical trials have been reported. Moreover, most of them the results from only one or times cell injection.The aim this study is to describe long-term treatment with allogeneic adipose-derived cells (ASCs) dog rheumatoid arthritis (RA), which rare canine disease.The RA received intravascular injection ASCs derived two healthy donors once month 11 months. To assess therapeutic effects...
This study aimed to develop a new biodegradable stent for peripheral artery disease (PAD) that could provide sufficient radial force maintain long-term patency and flexibility. All self-expandable hybrid stents were designed by using knitting structure composed of poly-L-lactic acid (PLLA) nitinol. Four different types implanted in 20 iliac arteries 10 mini pigs as follows: bare-metal (BMS) (group 1,<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"...
A 26 year old, healthy, 41 week primiparous woman received a patient-controlled epidural analgesia (PCEA) and experienced paraplegia 11 hours later after vaginal delivery. This was thought to be the result of complications from PCEA but there no specific abnormality on magnetic resonance imaging (MRI) lumbosacral spine. On an electromyography (EMG) study performed 15 days following delivery, signs tibial neuropathy were present peripheral nerve injury during delivery suspected. Motor...
The complex process of bone regeneration is influenced by factors such as inflammatory responses, tissue interactions, and progenitor cells. Currently, multiple traumas can interfere with fracture healing, causing the prolonging or failure healing. In these cases, grafting most effective treatment. However, there are several drawbacks, morbidity at donor site availability suitable materials. Advantages have been provided in this field a variety stem cell types. Adipose-derived cells (ASCs)...
A 13-year-old castrated male Yorkshire terrier dog had a soft splenic mass, which measured 11 cm in the greatest diameter. Microscopically, parenchyma of spleen was completely replaced by myxoid substances. Numerous spindle and stellate cells were loosely arranged stroma, variable vessels sizes observed loose matrix with poorly defined margins. Immunohistochemical analysis showed that tumor positive for desmin alpha-SMA, but negative S-100. Interestingly, intravascular embolus α-SMA...