A5027412567- Vibrio bacteria research studies
- Gut microbiota and health
- Bacterial biofilms and quorum sensing
- Prostate Cancer Treatment and Research
- PARP inhibition in cancer therapy
- DNA Repair Mechanisms
- Aquaculture disease management and microbiota
- Antibiotic Resistance in Bacteria
- Bacteriophages and microbial interactions
- Diet and metabolism studies
- Probiotics and Fermented Foods
- Pancreatic and Hepatic Oncology Research
- Liver Disease Diagnosis and Treatment
- Metabolomics and Mass Spectrometry Studies
- Genomics and Phylogenetic Studies
- Metabolism, Diabetes, and Cancer
- Cancer Research and Treatments
- Gastrointestinal motility and disorders
- Lipid metabolism and biosynthesis
- Allergic Rhinitis and Sensitization
- Pancreatic function and diabetes
- Muscle and Compartmental Disorders
- Lung Cancer Diagnosis and Treatment
- Dietary Effects on Health
- Gallbladder and Bile Duct Disorders
Huazhong University of Science and Technology
2016-2025
Southwest University
2020-2025
Xuzhou Medical College
2025
Tongji Hospital
2024
Chongqing Medical University
2024
Yueyang Hospital
2024
Shanghai University of Traditional Chinese Medicine
2024
Shanghai University
2024
Shandong University
2020-2024
University of Macau
2022-2023
Insulin resistance associates with chronic inflammation, and participatory elements of the immune system are emerging. We hypothesized that bacterial acting on distinct intracellular pattern recognition receptors innate system, such as peptidoglycan (PGN) nucleotide oligomerization domain (NOD) proteins, contribute to insulin resistance.Metabolic inflammatory properties were assessed in wild-type (WT) NOD1/2(-/-) double knockout mice fed a high-fat diet (HFD) for 16 weeks. was measured by...
Skeletal muscle is the primary site of dietary glucose disposal, a function that depends on insulin-mediated exocytosis GLUT4 vesicles to its cell surface. In skeletal and adipocytes, this response involves Akt signaling Rab-GAP (GTPase-activating protein) AS160/TBC1D4. Intriguingly, AS160-targeted Rabs appear differ, with Rab8A participating in cells Rab10 their activation by insulin unknown. 8A, 10, 13 belong same subfamily Rab-GTPases. Here we show promotes GTP loading Rab13 but not rat...
To successfully infect a host and cause the diarrheal disease cholera, Vibrio cholerae must penetrate intestinal mucosal layer express virulence genes. Previous studies have demonstrated that transcriptional regulator HapR, which is part of quorum sensing network in V. , represses expression Here, we show hapR also modulated by regulatory governs flagellar assembly. Specifically, FliA, alternative σ-factor (σ 28 ) activates late-class flagellin genes expression. In addition, mucin...
Background Interleukin-2 (IL-2) serves as a pioneer of immunotherapeutic agent in cancer treatment. However, there is considerable proportion patients who cannot benefit from this therapy due to the limited clinical responses and dose-limiting toxicities. Mounting evidence indicates that commensal microbiota shapes outcome immunotherapies. In study, we aim investigate enhancing effect Akkermansia muciniphila (AKK), beneficial microbe receiving attentions, on antitumor efficacy IL-2 explore...
Galunisertib (Gal) is a transforming growth factor (TGF-β) blockade which being investigated as potential tumor immunotherapy candidate drug in clinical trials. However, primary or acquired resistance often found the recruited cancer patients, limits its application. Tumor immune microenvironment can be regulated by intestinal microbiota, leading to different therapeutic outcomes. It hypothesized that manipulation of patients' microbiome early stage therapy may promising strategy improve...
Abstract Irritable bowel syndrome (IBS) is one of the functional gastrointestinal disorders characterized by chronic and/or recurrent symptoms abdominal pain and irregular defecation. Changed gut microbiota has been proposed to mediate IBS; however, contradictory results exist, IBS-specific microbiota, metabolites, their interactions remain poorly understood. To address this issue, we performed metabolomic metagenomic profiling stool serum samples based on discovery (n = 330) validation 101)...
Timely liver function recovery (LFR) is crucial for postoperative hepatocellular carcinoma (HCC) patients. Here, we established the significance of LFR on patient long-term survival through retrospective and prospective cohorts identified a key gut microbe, Bifidobacterium longum, depleted in patients with delayed recovery. Fecal microbiota transfer from HCC to mice similarly impacted time post hepatectomy. However, oral gavage B. longum improved repair these mice. In clinical trial...
Bacterial pathogens have evolved sophisticated signal transduction systems to coordinately control the expression of virulence determinants. For example, human pathogen Vibrio cholerae is able respond host environmental signals by activating transcriptional regulatory cascades. The that stimulate V. gene expression, however, are still poorly understood. Previous proteomic studies indicated ambient oxygen concentration plays a role in expression. In this study, we found under oxygen-limiting...
Phages invade microbes, accomplish host lysis and are of vital importance in shaping the community structure environmental microbiota. More importantly, most phages have very specific hosts; they thus ideal tools to manipulate microbiota at species-resolution. The main purpose MVP (Microbe Versus Phage) is provide a comprehensive catalog phage-microbe interactions assist users select phage(s) that can target (and potentially manipulate) microbes interest. We first collected 50 782 viral...
Abstract mBodyMap is a curated database for microbes across the human body and their associations with health diseases. Its primary aim to promote reusability of human-associated metagenomic data assist identification disease-associated by consistently annotating microbial contents collected samples using state-of-the-art toolsets manually curating meta-data corresponding hosts. organizes based on association diseases sites enable cross-dataset integration comparison. To help users find...
Refractory constipation is the most severe form of constipation, and its etiology remains unknown. The symptoms occur repeatedly, which brings great pain to patient's body psychology. Accumulating studies suggest that patients present a significant dysbiosis gut microbiota compared with healthy individuals. In this study, we analyzed composition fresh feces accumulated (old feces) refractory found there was difference between them. Through mouse model loperamide-induced it proved old could...
Abstract Current metagenome assembled human gut phage catalogs contained mostly fragmented genomes. Here, comprehensive virome detection procedure is developed involving virus‐like particle (VLP) enrichment from ≈500 g feces and combined sequencing of short‐ long‐read. Applied to 135 samples, a Chinese Gut Virome Catalog (CHGV) consisting 21,499 non‐redundant viral operational taxonomic units (vOTUs) that are significantly longer than those obtained by short‐read ≈35% (7675) complete...
To successfully propagate and cause disease, pathogenic bacteria must modulate their transcriptional activities in response to pressures exerted by the host immune system, including secreted immunoglobulins such as secretory IgA (S-IgA), which can bind agglutinate bacteria. Here, we present a previously undescribed flow cytometry-based screening method identify bacterial genes expressed vitro repressed during infections of Vibrio cholerae, an aquatic Gram-negative bacterium responsible for...
ABSTRACT Vibrio cholerae is the agent of severe diarrheal disease cholera, and it perpetuates in aquatic reservoirs when not host. Within host's intestines, bacteria execute a complex regulatory pathway culminating with production virulence factors that allow colonization cause disease. The ability V. to form biofilms thought aid its persistence environment passage through gastric acid barrier stomach. transcriptional activators VpsR VpsT are part biofilm formation-regulatory network. In...
Abstract Objective The aim of this study was to assess the esthetic and clinical outcomes immediate implantation using conventional flap‐less approach socket‐shield technique (SST). Methods This included 30 adult patients who underwent anterior teeth replacement fulfilled pre‐defined criteria. Patients were randomly allocated SST ( n = 15) (control, groups. evaluated by assessing degree soft‐tissue recession pink scores (PESs). Clinical parameters, including modified plaque index, sulcus...
Insulin promotes glucose uptake into skeletal muscle through recruitment of transporter 4 (GLUT4) to the plasma membrane. Rab GTPases are molecular switches mobilizing intracellular vesicles, and Rab13 is necessary for insulin-regulated GLUT4-vesicle exocytic translocation in cells. We show that engages scaffold protein MICAL-L2 this process. RNA interference-mediated knockdown or truncated (MICAL-L2-CT) impaired insulin-stimulated GLUT4 translocation. increased binding MICAL-L2, assessed by...
Recent clinical studies have demonstrated a beneficial effect of Saccharomyces boulardii (S. boulardii) in inflammatory bowel disease (IBD). However, the underlying mechanisms remain poorly defined. In this study, we investigated modulating S. on intestinal microbiota humanized mice with dextran sulfate sodium (DSS)-induced colitis. The were fed an boulardii-supplement diet for 16 days before DSS treatment. results showed that feeding significantly ameliorated colon damage and regulated...
DNA methylation plays a crucial role in the survival of bacteriophages (phages), yet understanding their genome remains limited. In this study, patterns are analyzed 8848 metagenome-assembled high-quality phages from 104 fecal samples using single-molecule real-time sequencing. The results demonstrate that 97.60% gut exhibit methylation, with certain factors correlating densities. Phages higher densities appear to have potential viability advantages. Strikingly, more than one-third possess...
The oral cavity is the second most microbially rich region of human body, and many studies have shown that there a strong association between microorganisms health. Some pathogenic bacteria produce biofilms harmful metabolites in mouth may cause problems such as malodor, periodontitis, dental caries. Altering microbiota by using probiotics alleviate health problems. Thus, multi-function screening, we aimed to identify can significantly improve main parameters were inhibition growth, biofilm...
Rotary Position Embedding (RoPE) has shown strong performance in text-based Large Language Models (LLMs), but extending it to video remains a challenge due the intricate spatiotemporal structure of frames. Existing adaptations, such as RoPE-3D, attempt encode spatial and temporal dimensions separately suffer from two major limitations: positional bias attention distribution disruptions video-text transitions. To overcome these issues, we propose Video (VRoPE), novel encoding method tailored...