A5059333507- Renal cell carcinoma treatment
- Autophagy in Disease and Therapy
- Endoplasmic Reticulum Stress and Disease
- Ferroptosis and cancer prognosis
- Epigenetics and DNA Methylation
- Cancer, Hypoxia, and Metabolism
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Cancer Research and Treatments
- Cancer-related gene regulation
- Sulfur Compounds in Biology
- Cancer Mechanisms and Therapy
- Renal and related cancers
- Extracellular vesicles in disease
- RNA modifications and cancer
- NF-κB Signaling Pathways
- Adenosine and Purinergic Signaling
- S100 Proteins and Annexins
- Cancer Cells and Metastasis
- Urinary Bladder and Prostate Research
- Prostate Cancer Treatment and Research
- Cancer-related molecular mechanisms research
- Neuroscience of respiration and sleep
- Prostate Cancer Diagnosis and Treatment
- Chemotherapy-induced organ toxicity mitigation
Qilu Hospital of Shandong University
2015-2024
University of Cincinnati Medical Center
2021
Shandong University
2010-2012
Clear cell renal carcinoma (ccRCC) is the most common histological subtype of carcinoma, and tumour growth metastasis ccRCC are related to prognosis. N4-acetylcytidine (ac4C) one major modifications RNA known be mediated by N-acetyltransferase 10 (NAT10). The role NAT10 in cancer gradually being revealed, although NAT10-mediated ac4C modification has not been reported. In this study, was found upregulated tissues associated with a poor prognosis patients. HIF-1α activated expression at...
BACKGROUND Bladder cancer (BC) is the most common urological malignant tumor. In BC, aberrant DNA methylation believed to be associated with carcinogenesis. Therefore, identification of key genes and pathways could help determine potential molecular mechanisms BC development. MATERIAL AND METHODS Microarray data on gene expression were downloaded from Gene Expression Omnibus (GEO) database. Abnormal methylated/expressed analyzed by GEO2R statistical software R. Ontology term enrichment Kyoto...
Increasing evidence indicates that the dysregulation of circular RNAs (circRNAs) plays important roles in tumor progressions.In this study, we first analyzed circ-FOXO3 level bladder cancers (BCs), and then BC cell lines were transfected with expression vector, proliferation, migration, invasion abilities analyzed. We also used bioinformatics tools to predict potential-binding miRNAs for circ-FOXO3, luciferase reporter assay was verification binding miRNAs. For further potential...
Eukaryotic translation initiation factors (eIFs) constitute a new class of therapeutic cancer targets. EIF3b is the major scaffold protein eIF3 (the largest core eIFs). We sought to define role played by and mechanism action eIF3b in patients with clear cell renal carcinoma (ccRCC). found that high-level expression tumors was not only associated an aggressive tumor phenotype, but also independently prognostic for ccRCC. Knockdown impaired Akt pathway, thus inhibiting proliferation disrupting...
Renal cell carcinoma (RCC) is the most lethal of all genitourinary malignancies. Distant metastasis represents major cause death in patients with RCC. Recent studies have implicated AAA+ ATPase pontin many cellular activities that are highly relevant to carcinogenesis. In this study, we demonstrate for first time was up-regulated RCC, and plays a previously unknown pro-invasive role metastatic progression RCC through epithelial-to-mesenchymal transition (EMT) pathway. 28 pairs freshly frozen...
BACKGROUNDClear cell renal carcinoma (ccRCC) is the most common histologically defined cancer. However, it not a uniform disease and includes several genetic subtypes with different prognoses. ccRCC also characterized by distinctive metabolic reprogramming. Tobacco smoking (TS) an established risk factor for ccRCC, unknown effects on tumor pathobiology.METHODSWe investigated landscape of ccRCCs paired normal kidney tissues using integrated transcriptomic, metabolomic, metallomic approaches...
CIP2A is a well-known oncoprotein whose expression elevated in multiple human solid tumor types. However, its role renal cell carcinoma (RCC) development poorly understood. Thus, our present study, we used the cancer lines 786-O, A498 and CAKI-1 epithelial line HK-2 to clarify function of RCC. We found that much higher RCC cells than normal cell. Lentivirus covered coding region cDNA sequence siRNA were up down regulate vitro. overexpression promoted G1/S transition proliferation. In...
Background: Hypopharyngeal squamous cell carcinoma (HSCC) is among the most lethal tumors encountered in head and neck, currently lacks satisfactory therapeutic targets. Platelet activating factor acetylhydrolase 1B3 (PAFAH1B3), a cancer-relevant metabolic driver, reported to play critical role controlling tumorigenesis aggressiveness several types of cancers. However, PAFAH1B3 HSCC progression has not yet been identified. Methods: The expression pattern was examined using...
Major histocompatibility complex class I-related chains A (MICA), a ligand of Natural killer group 2, member D (NKG2D) receptor, is broadly upregulated in epithelial originated tumor cells. MICA plays critical role the immune surveillance against cells and associated with prognosis several malignancies. The aim this study to evaluate clinical biological significance clear cell renal carcinoma (ccRCC). expression was analyzed by quantitative real-time PCR (qRT-PCR) immunohistochemistry (IHC)....
LC3s are canonical proteins necessary for the formation of autophagosomes. We have previously established that two paralogs, LC3B and LC3C, opposite activities in renal cancer, with playing an oncogenic role LC3C a tumor-suppressing role. is evolutionary late gene present only higher primates humans. Its most distinct feature C-terminal 20-amino acid peptide cleaved process glycine 126 lipidation. Here, we investigated mechanisms LC3C-selective autophagy. autophagy requires noncanonical...
To evaluate the role of Cystatin C (Cys-C) in tumorigenesis and progression prostate cancer (PCa), we retrospectively collected clinical information from records 492 benign prostatic hyperplasia (BPH), 48 intraepithelial neoplasia (PIN), 173 PCa patients, whose disease was newly diagnosed histologically confirmed. Pretreatment serum Cys-C levels were compared across various groups then analyzed to identify relationships, if any, with pathological characteristics patient group. There no...
Exosomes, key components of the tumour microenvironment, can mediate intercellular communication through delivery various signalling molecules, including microribonucleic acids (miRNAs), and ultimately participate in regulating process development. In this study, we aimed to investigate reason mechanism by which exosomal miRNAs derived from gastric cancer cells affect carcinogenesis metastasis. Among these miRNAs, microRNA-128-3p (miR-128-3p) was highly expressed serum exosomes isolated...
Lysomembrane-associated protein 1 (LAMP1), known to exhibit differential expression in various tumor types and play a crucial role the development of tumors. Clear cell Renal Cell Carcinoma (ccRCC) is still most common pathological type renal carcinoma with poor prognosis. However, LAMP1 its underlying molecular mechanism ccRCC remain elusive.
Despite considerable progress has been made in the understanding of genetics and molecular biology renal cell carcinoma (RCC), therapeutic options patients with papillary (PRCC) are limited. Immunotherapy based on immune checkpoint inhibitors (ICIs) become a hot point researching new drug for tumor tested number human clinical trials. In this study, an immune-related gene prognostic index (IRGPI) was developed provided comprehensive systematic analysis distinct phenotypic portraits...
e14083 Background: Hypoxia is a unique microenvironment in solid tumors, including ESCC. We aim to investigate the interaction between hypoxia-inducible factor-1α (HIF-1α), COX-2 and programmed cell death ligand-1 (PD-L1) uncover role of HIF-1α inhibitor PX-478 as potential targeted therapy Methods: Immunohistochemical staining was performed levels HIF-1α, PD-L1 from 133 pT3N0M0 ESCC patients after radical resection. The prognostic value expression correlation with clinicopathologic features...
Abstract LC3s are canonical proteins necessary for the formation of autophagosomes. We have previously established that two paralogs, LC3B and LC3C, opposite activities in renal cancer, with playing oncogenic role LC3C tumor suppressing role. is an evolutionary late gene, present only higher primates humans. Its most distinct feature a C-terminal 20 amino acid peptide cleaved process glycine 126 lipidation. Here we investigated mechanisms selective autophagy. autophagy requires noncanonical...