A5033403580- Hormonal Regulation and Hypertension
- Adrenal and Paraganglionic Tumors
- Diet and metabolism studies
- Tissue Engineering and Regenerative Medicine
- Urological Disorders and Treatments
- Hernia repair and management
- Pituitary Gland Disorders and Treatments
- Renal cell carcinoma treatment
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- RNA Research and Splicing
- Organ Donation and Transplantation
- Cancer-related Molecular Pathways
- Cancer-related gene regulation
- Glycosylation and Glycoproteins Research
- Ureteral procedures and complications
- Pancreatic and Hepatic Oncology Research
- Wnt/β-catenin signaling in development and cancer
- Cancer-related molecular mechanisms research
- Connexins and lens biology
- Molecular Biology Techniques and Applications
- Cancer Cells and Metastasis
- Infectious Aortic and Vascular Conditions
- Neuroinflammation and Neurodegeneration Mechanisms
- Cell death mechanisms and regulation
Qilu Hospital of Shandong University
2011-2025
Shandong University
2011-2024
Shanghai First People's Hospital
2012
University of Calabria
2011
Baylor College of Medicine
2011
Shanghai Jiao Tong University
2009
University of Illinois Chicago
1997
<title>Abstract</title> Objective Currently, bladder reconstruction using gastrointestinal segments is considered as the gold standard for repair or augmentation. However, postoperative complications including bowel dysfunction, metabolic abnormalities, chronic urinary tract infection and stone formation are common. This study aims to evaluate utility of compound graft patch by seeding mesothelial cells onto autogenous granulation tissue. Methods 22 Fr silastic tubes were implanted...
Cancerous inhibitor of protein phosphatase 2A (CIP2A) drives cellular transformation. The objective this study was to detect the potential effects CIP2A in renal cell carcinomas (RCCs).A total 107 RCC patients were involved study. expression investigated by real-time PCR and immunohistochemistry. In vitro, we examined c-Myc tested migration invasion capability A498 KRC/Y cells with scratch assay Matrigel after down-regulating using siRNA.Cancerous over-expressed tissues. Clear showed an even...
Eukaryotic translation initiation factors (eIFs) constitute a new class of therapeutic cancer targets. EIF3b is the major scaffold protein eIF3 (the largest core eIFs). We sought to define role played by and mechanism action eIF3b in patients with clear cell renal carcinoma (ccRCC). found that high-level expression tumors was not only associated an aggressive tumor phenotype, but also independently prognostic for ccRCC. Knockdown impaired Akt pathway, thus inhibiting proliferation disrupting...
Berberine, a quaternary amine and isoquinoline alkaloid, has been proposed to have antimetastatic effects on many types of tumor cells; however, its exact inhibitory mechanisms with bladder cancer cells remain unclear. We used berberine siRNA technology interfere the expression heparanase in T24 cells, detected mRNA protein by reverse transcription PCR Western blot respectively, investigated their migration invasion using transwell chamber. Our results showed that both were highly expressed...
<b><i>Introduction:</i></b> This study aims to investigate whether mesothelial cells could function as seed construct tissue-engineered peritoneum-like tissue for urethral reconstruction in a rabbit model. <b><i>Materials and Methods: </i></b>Bladder acellular matrices were prepared trimmed 1.5 × 1 cm. Nine male rabbits underwent omentum biopsy autologous isolated. After vitro expansion, the seeded onto incubated 7 days. In 18 rabbits,...
<i>Objective:</i> To investigate whether the peritoneal cavity could function as a bioreactor to produce autologous tubular grafts for ureteral reconstruction in beagles. <i>Materials and Methods:</i> 8-Fr Silastic tubes were implanted into cavities of 6 female At 3 weeks, harvested tissue covering was gently everted. A segment cm length right mid-ureter, involving two thirds its diameter, removed parallel axis, leaving third wall. 5-Fr double-J stent inserted ureter...
Abstract Background Laparoscopic adrenalectomy for pheochromocytoma is associated with high risk of intraoperative hemodynamic instability. Our study aimed to identify predictive factors instability during laparoscopic resection pheochromocytoma. Methods Between January 2011 and December 2021, 136 patients underwent unilateral The were divided into 2 groups depending on the presence or absence surgery. Intraoperative parameters compared between groups. Patient demographic characteristics...
C57 BL mice were injected daily with either saline or varied doses of cocaine (5-50 mg/kg), and thymocyte subpopulations analyzed 4 hr after the fifth injection. Mice 25 50 mg/kg showed a decrease in percentage CD4+8+ cells increase CD4-8-, CD4+, CD8+ cells. The absolute numbers each subpopulation, calculated by multiplying subpopulation total cell number, revealed an extensive decline CD4+8+, CD8+, no change CD4+ subpopulation. Flow cytometric analysis thymocytes electrophoresis DNA...
Objective . This study was to evaluate the utility of compound graft for tubularized urethroplasty by seeding mesothelial cells onto autogenous granulation tissue. Methods Silastic tubes were implanted subcutaneously in 18 male rabbits, which nine underwent omentum biopsies simultaneously vitro expansion cells. The tissue covering harvested 2 weeks after operation. Mesothelial seeded and cocultured with 7 days. A pendulous urethral segment 1.5 cm totally excised. Urethroplasty performed...
Abstract Background Cortisol-producing adrenocortical adenoma (CPA) during pregnancy rarely occurs in clinic. Growing evidence suggests that DNA methylation plays a key role adenomas. The present study aims to examine the genome-wide profiles and identify differences signatures of non-pregnant pregnant patients with CPA. Results Four twelve CPA were enrolled. had higher serum cortisol, Estradiol, Progesterone, human chorionic gonadotropin concentration, while having lower FSH...
Abstract Background There is a lack of data regarding the appropriateness transperitoneal and retroperitoneal approaches for homolateral laparoscopic adrenalectomy. The aim this study to compare lateral approach left-sided right-sided adrenalectomy respectively. Methods Between January 2014 December 2019, 242 patients underwent 252 For left side, was used in 132 (103 with tumors < 5 cm 29 ≥ cm) 110 (102 8 cm). right 139 (121 18 113 11 Patient characteristics perioperative outcomes were...
Abstract Background The dysfunction of RNA binding proteins (RBPs) is associated with various inflammation and cancer. occurrence progression tumors are closely related to the abnormal expression RBPs. There few studies on RBPs in clear cell renal carcinoma (ccRCC), which allows us explore role ccRCC. Methods We obtained gene data clinical ccRCC from Cancer Genome Atlas (TCGA) database extracted all information performed differential analysis Risk model were constructed based differentially...
Background Gap junction proteins (GJPs) are a class of channel that closely related to cell communication and tumor development. The objective this study was screen out GJPs prognostic signatures (GRPS) associated with clear renal carcinoma (ccRCC). Materials Methods microarray data for ccRCC patients were obtained from Gene Expression Omnibus (GEO) database, along RNA sequencing paired normal tissues Cancer Genome Atlas (TCGA) database. In the TCGA least absolute shrinkage selection...
Background:To investigate whether the retroperitoneal or transperitoneal approach is preferable for right-sided laparoscopic donor nephrectomy (R-LDN).Material/Methods:We retrospectively compared and recipient outcomes of R-LDNs performed with a standard (n=21) semi-open (n=32).Results:Patient demographics were similar between groups. The group had shorter operative time (89.5 min vs. 105 min, p<0.001), WIT (102 s 120 s, longer renal veins (2.5 cm 2.2 cm, p<0.001). No conversions to...
Background: Cushing's syndrome (CS) during pregnancy due to cortisol-producing adrenocortical adenoma (CPA)rarely occurs in clinical. Growing evidence suggests that DNA methylation plays a key role adenomas. The present study aims examine the genome-wide profiles and identify differences signatures of non-pregnant pregnant patients with CPA. Methods: Clinical data samples were obtained analyzed from non-pregnant(n=12) pregnant(n=4) Cell proliferation was examined by Ki-67 expression....
Abstract Background: Therapeutic strategies directed at inhibiting the action of ERa using antiestrogens, such as tamoxifen (Tam), or HER2 signalling a monoclonal antibody-Trastuzumab (Tras) are standard therapies offered to women with ERa/HER2−positive cancer. However, not all patients respond these targeted therapies, and large number who do will eventually develop disease progression recurrence while on therapy. EBP50 functions molecular scaffold coordinate diverse range regulatory...