A5013663857- Optical Imaging and Spectroscopy Techniques
- Photoacoustic and Ultrasonic Imaging
- Advanced optical system design
- Non-Invasive Vital Sign Monitoring
- Optical Coatings and Gratings
- Adaptive optics and wavefront sensing
- Advanced Optical Imaging Technologies
- Gas Sensing Nanomaterials and Sensors
- Photorefractive and Nonlinear Optics
- Luminescence Properties of Advanced Materials
- Laser-induced spectroscopy and plasma
- Spectroscopy and Laser Applications
- Digital Radiography and Breast Imaging
- Hemodynamic Monitoring and Therapy
- Spectroscopy Techniques in Biomedical and Chemical Research
- Coastal wetland ecosystem dynamics
- Plasma Applications and Diagnostics
- Photonic and Optical Devices
- Laser Design and Applications
- Radiation Dose and Imaging
- Geochemistry and Geologic Mapping
- Solid-state spectroscopy and crystallography
- Catalytic Processes in Materials Science
- Laser-Plasma Interactions and Diagnostics
- Wind Turbine Control Systems
Qilu Hospital of Shandong University
2024-2025
Xiamen University
2024
Guizhou Electric Power Design and Research Institute
2023-2024
Zhongshan Hospital
2024
Zhongnan Hospital of Wuhan University
2024
Wuhan University
2024
Physikalisch-Technische Bundesanstalt
2017-2023
Zhejiang University
2012-2023
State Key Laboratory of Modern Optical Instruments
2014-2023
Institute of Biocybernetics and Biomedical Engineering
2021-2022
Breast cancer (BC) is the most prevalent among women worldwide, with increasing incidence rates, particularly in China. Given high costs of Oncotype DX (ODX) testing, which predicts recurrence scores (RSs) on basis gene expression, developing a nomogram utilizing clinicopathological variables may provide an accessible alternative for risk stratification. We conducted retrospective analysis 703 estrogen receptor (ER)-positive, HER2-negative T1-3N0M0 BC patients who underwent ODX testing at...
The control of light propagation in highly tilted geometry by freeform illumination optics has numerous applications. However, difficulties associated with the tailoring surfaces significantly limit scope Here, for first time, to best our knowledge, we develop a general formulation designing geometry. numerical and experimental results show that when precise is achieved, lenses are efficient can reduce glare trespass.
Significance: Multi-laboratory initiatives are essential in performance assessment and standardization—crucial for bringing biophotonics to mature clinical use—to establish protocols develop reference tissue phantoms that all will allow universal instrument comparison. Aim: The largest multi-laboratory comparison of near-infrared diffuse optics is presented, involving 28 instruments 12 institutions on a total eight experiments based three consolidated (BIP, MEDPHOT, NEUROPT) as implemented...
We present broadband measurements of the optical properties tissue-mimicking solid phantoms using a single integrating sphere to measure hemispherical reflectance and transmittance under direct illumination at normal incident angle. These are traceable scales. An inversion routine output adding-doubling algorithm restricted was developed produce parameters sample along with an uncertainty budget each wavelength. The results for two types compared by time-resolved approaches. between our...
Freeform optics constitutes a new technology that is currently driving substantial changes in beam shaping. Most of the current shaping systems are elaborately tailored for fixed optical properties, which means output light distribution system usually cannot be changed. What we present here class systems, properties can changed to meet requirements different applications. The proposed composed freeform lens and non-classical zoom designed by ray aiming conservation energy instead aberration...
Designing freeform optics for illuminating hard-to-reach areas is a challenging and rewarding issue. The current designs of illumination are mostly valid in the applications which region interest easily accessible. What we present here general formulation designing lenses areas. In this method, lens consists two elaborately designed surfaces, by both intensity distribution wave-front light beam manipulated desired manner. after refraction further guided through light-guiding system to...
Yttrium aluminum garnet (YAG) nanopowders were synthesized by sol-gel method using nitrate, yttrium and citric acid as starting materials, de-ionized water, ethanol, ethylene glycol solvents, respectively. The phase formation process, state of particle size distribution (PSD), compositions, morphological characteristics, thermal behavior the powders investigated means x-ray diffractometry, PSD, Fourier transform infrared, transmission electronic microscope, thermogravimetry-differential...
In this study, we collected two sediment cores (C1 and C2) from the Andong tidal flat, Hangzhou Bay, studied temporal variations of heavy metals in cores. Vertical distributions were almost unchanged both before 2000. After 2000, however, metal concentrations increased dramatically, suggesting that sediments have been affected by enhanced human pollution recent decade. core C1, severely polluted Pb, moderately to considerably Cr Zn, low other metals. The C2 was relatively unpolluted 2000...
Time-domain optical brain imaging techniques introduce a number of different measurands for analyzing absorption changes located deep in the tissue, complicated by superficial and noise. We implement method that allows analysis, quantitative comparison performance ranking under various conditions – including values reduced scattering coefficient, thickness layer, source-detector separation. Liquid phantom measurements Monte Carlo simulations were carried out two-layered geometry to acquire...
Abstract Soft actuators, an emerging field in robotics, have great potential for wide‐ranging applications biology, medicine, engineering, and oceanography. Photoactuators that are stimulated by light to produce reversible mechanical deformation attracted significant interest recent years owing their advantages of high resolution, fast switching, flexible controllability, electromagnetic interference immunity. Conventional photoactuators rely on free‐space illumination, which limits the...
Optical camera communication (OCC) systems, which utilize image sensors embedded in commercial-off-the-shelf devices to detect time and spatial variations light intensity for enabling data communications, have stirred up researchers' interest. Compared a direct OCC system whose maximum rate is strongly determined by the LED source size, reflected can break that limitation since captures rays reflecting off an observation plane (e.g., wall) instead of those directly emanated from source....
An air-spark switch plasma was diagnosed by the Mach–Zehnder laser interferometer with ultra-high spatial and temporal resolution. The interferograms containing phase shift information at different time were obtained. distributions of extracted numerically processing interferograms. three-dimensional (3D) electron density then working process described analyzing evolution density.
We investigated the morphology and intracellular motility of mammary epithelial cell (MCF10DCIS.com) spheroids cultured in 3D artificial extracellular matrix under perfluorooctanoic acid (PFOA) exposure. Dynamic optical coherence tomography (OCT) was employed for real-time, non-invasive imaging these longitudinally over 12 days PFOA exposures up to 500 µM. Despite no significant changes volume or asphericity spheroids, morphological alterations were observed OCT images at 100 µM on Day from...
A novel methodology for solving the inverse problem of diffuse optics two-layered structures is proposed to retrieve absolute quantities optical absorption and reduced scattering coefficients layers simultaneously. liquid phantom with various properties in deep layer prepared experimentally investigated using space-enhanced time-domain method. Monte-Carlo simulations are applied analyze different measurements time domain, space by new methodology. The deviations retrieved values from nominal...
Freeform and precise irradiance tailoring in arbitrarily oriented planes is an ultimate goal of nonimaging optics has not been well addressed. In this paper, we develop a general formulation for arbitrary three-dimensional (3D) space using freeform lenses. This method breaks any symmetric constraints imposed on the geometrical arrangement conventional beam shaping systems, yielding high-performance systems with new functions flexible arrangements 3D space. paves way broad application optics....
An Al2O3 xerogel with a distinctive microstructure is studied for the application of laser absorption spectroscopy oxygen. The has an exceptionally high porosity (up to 88%) and large pore size 3.6 µm). Using method gas-in-scattering media (GASMAS), long optical path length (about 3.5m) enhancement factor (over 300 times) are achieved as result extremely strong multiple-scattering when light transmitted through air-filled, hollow-sphere alumina xerogel. We investigate how micro-physical...
We report on a procedure to build and characterize solid tissue-mimicking phantoms of polydimethylsiloxane (PDMS) polymers. Controlled inclusion light scattering titanium dioxide (TiO<sub>2</sub>) nanoparticles enables the creation having tunable properties with reduced coefficients consistent across different measurement platforms including an integrating sphere time-resolved diffuse optical spectroscopic system. Backscatter confocal microscopy is also used shape distribution included...
A multivariate method integrating time and space resolved techniques of near-infrared spectroscopy is proposed for simultaneously retrieving the absolute quantities optical absorption scattering properties in tissues. The time-domain feature photon migration advantageously constrained regularized by its spatially-resolved amplitude patterns inverse procedure. Measurements tissue-mimicking phantoms with various are analyzed Monte-Carlo simulations to validate performance. uniqueness,...
Performance assessment of instruments is a growing demand in the diffuse optics community and there definite need to get together address this issue. Within EU Network BITMAP1, we initiated campaign for performance evaluation 10 optical instrumentation from 7 partner institutions adopting set 3 well accepted, standardized protocols. A preliminary analysis outcome along with future perspectives will be presented.
For homogeneous diffraction efficiency of the recorded volume holographic optical element (vHOE), a recording beam uniform intensity is required. A multicolor vHOE by an RGB laser source with Gaussian distribution; during equal exposure time, beams different intensities would result in efficiencies areas. In this paper, we present wide-spectrum shaping system design method, which incident can be controlled into distribution spherical wavefront. This added to any obtain without altering...