A5079435268- Optical Imaging and Spectroscopy Techniques
- Non-Invasive Vital Sign Monitoring
- Photoacoustic and Ultrasonic Imaging
- Spectroscopy Techniques in Biomedical and Chemical Research
- Hemodynamic Monitoring and Therapy
- Neonatal and fetal brain pathology
- Calibration and Measurement Techniques
- Infrared Thermography in Medicine
- Digital Radiography and Breast Imaging
- Radiation Dose and Imaging
- Thermoregulation and physiological responses
- Advanced Optical Sensing Technologies
Polish Academy of Sciences
2019-2023
Institute of Biocybernetics and Biomedical Engineering
2019-2023
Near-infrared spectroscopy (NIRS) is an established technique for measuring tissue oxygen saturation (StO2), which of high clinical value. For tissues that have layered structures, it challenging but clinically relevant to obtain StO2 the different layers, e.g. brain and scalp. this aim, we present a new method data analysis time-domain NIRS (TD-NIRS) two-layered blood-lipid phantom. The enables accurate determination even large changes absorption coefficient (Δµa) in multiple layers. By...
Significance: Multi-laboratory initiatives are essential in performance assessment and standardization—crucial for bringing biophotonics to mature clinical use—to establish protocols develop reference tissue phantoms that all will allow universal instrument comparison. Aim: The largest multi-laboratory comparison of near-infrared diffuse optics is presented, involving 28 instruments 12 institutions on a total eight experiments based three consolidated (BIP, MEDPHOT, NEUROPT) as implemented...
We present and validate a multi-wavelength time-domain near-infrared spectroscopy (TD-NIRS) system that avoids switching wavelengths instead exploits the full capability of supercontinuum light source by emitting acquiring signals for whole chosen range wavelengths. The was designed muscle brain oxygenation monitoring in clinical environment. A pulsed laser emits broadband each two detection modules acquires distributions times flight photons (DTOFs) 16 spectral channels (used width 12.5 nm...
Time-domain optical brain imaging techniques introduce a number of different measurands for analyzing absorption changes located deep in the tissue, complicated by superficial and noise. We implement method that allows analysis, quantitative comparison performance ranking under various conditions – including values reduced scattering coefficient, thickness layer, source-detector separation. Liquid phantom measurements Monte Carlo simulations were carried out two-layered geometry to acquire...
Visual stimulation is one of the most commonly used paradigms for cerebral cortex function investigation. Experiments typically involve presenting to a volunteer black-and-white checkerboard with contrast-reversing at frequency 4 16 Hz. The aim present study was investigate influence flickering on amplitude changes in concentration oxygenated and deoxygenated hemoglobin. hemoglobin concentrations were assessed use high resolution diffuse optical tomography method. Spatial distributions...
Time-resolved near infrared spectroscopy is considered to be a gold standard technique when measuring absolute values of tissue optical properties, as it provides separable and independent information about both absorption scattering. However, time-resolved instruments require an accurate characterization by the instrument response function in order decouple contribution itself from measurement. In this work, new approach methodology analysing data presented where influence eliminated...
Research on the spatial distribution of sensitivity time-domain near infrared diffuse reflectance measurement is reported in this paper. The main objective investigation to validate theoretically calculated profiles for a geometry with two detectors and sources which statistical moments distributions time flight photons (DTOFs) are spatially restricted region underneath detectors. For dual subtraction method, smaller sensitivities changes appearing superficial layer medium were observed...
A novel methodology for solving the inverse problem of diffuse optics two-layered structures is proposed to retrieve absolute quantities optical absorption and reduced scattering coefficients layers simultaneously. liquid phantom with various properties in deep layer prepared experimentally investigated using space-enhanced time-domain method. Monte-Carlo simulations are applied analyze different measurements time domain, space by new methodology. The deviations retrieved values from nominal...
Time-resolved near-infrared spectroscopy (TR-NIRS) measurements can be used to recover changes in concentrations of tissue constituents ( ΔC ) by applying the moments method and Beer-Lambert law. In this work we carried out error propagation analysis allowing calculate standard deviations uncertainty estimation . Here, show process choosing wavelengths for evaluation hemodynamic (oxy-, deoxyhemoglobin) metabolic (cytochrome-c-oxidase (CCO)) responses within brain as measured with an in-house...
Neonates with hypoxic-ischaemic (HI) brain injury were monitored using a broadband near-infrared spectroscopy (NIRS) system in the neonatal intensive care unit. The aim of this work is to use NIRS cerebral oxygenation data (HbD = oxygenated-haemoglobin – deoxygenated-haemoglobin) combined arterial saturation (SaO2) from pulse oximetry calculate blood flow (CBF) based on oxygen swing method, during spontaneous desaturation episodes. method Fick's principle and uses HbD as tracer; when sudden...
Performance assessment of instruments is a growing demand in the diffuse optics community and there definite need to get together address this issue. Within EU Network BITMAP1, we initiated campaign for performance evaluation 10 optical instrumentation from 7 partner institutions adopting set 3 well accepted, standardized protocols. A preliminary analysis outcome along with future perspectives will be presented.
Absolute concentrations of oxyhaemoglobin and deoxyhaemoglobin obtained using multi-wavelength measurements time-resolved diffuse reflectance signals are presented.The aim was to test how accurately the concentration oxy-and deoxyhemoglobin can be measured simultaneously at multiple wavelengths.The optical were collected system constructed by author's group a , which records distribution in time flight photons (DTOFs) 16 spectral channels ranging from 650 850 nm.The carried out on liquid...
The study investigated cerebral oxygenation in healthy volunteers using in-house developed NIRS, focusing on hemodynamic responses to position of a membrane the lower body negative pressure (LBNP) chamber.
Open Data philosophy is becoming more popular among scientists. approach aims to transform science by making high-quality and well-documented scientific data open everybody in order promote collaboration transparency. In diffuse optical near-infrared spectroscopy community, a large measurement dataset collected with state-of-the-art instrumentation applied on well-defined phantoms still missing. Within that context, several European labs from BitMap network1 have standard involving the...
Performance assessment and standardization are indispensable for instruments of clinical relevance in general instrumentation based on photon migration/diffuse optics particular. In this direction, a multi-laboratory exercise was initiated with the aim assessing comparing their performances. 29 diffuse optical belonging to 11 partner institutions European level Marie Curie Consortium BitMap1 were considered exercise. The enrolled covered different approaches (continuous wave, CW; frequency...
Time-domain fNIRS facilitates the elimination of influence extracerebral, systemic effects on measured signals since it contains time-of-flight information that is related to penetration depth. Employing perturbation and MonteCarlo simulations, we quantitatively characterized compared performance measurands based moments time windows distributions. We extend our analysis investigate whether higher MellinLaplace (ML) promise improvements in performance. The comparison spatial sensitivity...
A multi-laboratory exercise, involving 29 diffuse optical instruments, aimed at performance assessment of optics instruments on standardized protocols is presented. The overarching methodology and future actions will also be discussed.
The effect of hemoglobin spectra on quantification concentrations oxy-, deoxyhemoglobin, and oxygen saturation were studied using multi-wavelength time-domain NIRS measurements performed a series blood-lipid phantoms.