A5022910841- Optical Imaging and Spectroscopy Techniques
- Non-Invasive Vital Sign Monitoring
- EEG and Brain-Computer Interfaces
- Adenosine and Purinergic Signaling
- Muscle activation and electromyography studies
- Infrared Thermography in Medicine
- Glaucoma and retinal disorders
- Functional Brain Connectivity Studies
- Medical Imaging and Analysis
- Cardiovascular and exercise physiology
- Human-Automation Interaction and Safety
- Neural dynamics and brain function
- Spatial Cognition and Navigation
- Virtual Reality Applications and Impacts
- 3D Printing in Biomedical Research
- Neural Networks and Applications
- Stroke Rehabilitation and Recovery
- Calibration and Measurement Techniques
- Additive Manufacturing and 3D Printing Technologies
- Advanced Optical Sensing Technologies
- DNA and Nucleic Acid Chemistry
- Radiomics and Machine Learning in Medical Imaging
- Heart Rate Variability and Autonomic Control
- Neuroscience and Neural Engineering
- Hand Gesture Recognition Systems
Institute of Biomedical Technologies
2021-2024
National Research Council
2022-2024
Istituto per le Tecnologie Didattiche
2021-2023
Politecnico di Milano
2018-2022
Institute of Molecular Bioimaging and Physiology
2017-2018
Leiden University
1995
Centre for Human Drug Research
1993
University of Amsterdam
1983-1984
Measurement of muscle oxidative metabolism is interest for monitoring the training status in athletes and rehabilitation process patients. Time domain near infrared spectroscopy (TD NIRS) an optical technique that allows non-invasive measurement hemodynamic parameters muscular tissue: concentrations oxy- deoxy-hemoglobin, total hemoglobin content, tissue oxygen saturation. In this paper, we present a novel TD NIRS medical device metabolism. A custom-printed 3D probe, able to host elements...
The interest for Fused Deposition Modelling (FDM) in the field of Diffuse Optics (DO) is rapidly increasing. most widespread FDM materials are polylactic acid (PLA) and acrylonitrile butadiene styrene (ABS), thanks to their low cost easiness-to-print. This why, this study, 3D printed samples PLA ABS were optically characterized range from UV up IR wavelengths, order test possible employment probe construction DO applications. To purpose, measurements with Near Infrared Spectroscopy...
Virtual reality (VR) is a technology that allows users to experience multisensory and interactive environments simulate real or imaginary scenarios. The effect of different VR immersive on mental workload (MWL), i.e., the amount resources required perform task, still debated; however potential role EEG in this context was never exploited. This paper aims investigate effects MWL performing cognitive task environment two conditions characterized by degrees immersion using multimodal approach...
Background and Objective: Mental workload (MWL) is a relevant construct involved in all cognitively demanding activities, its assessment an important goal many research fields. This paper aims at evaluating the reproducibility sensitivity of MWL from EEG signals considering effects different electrode configurations pre-processing pipelines (PPPs). Methods: Thirteen young healthy adults were enrolled asked to perform 45 min Simon’s task elicit cognitive demand. data collected using...
Brain plasticity and functional reorganization are mechanisms behind motor recovery of patients after an ischemic stroke. The study resting-state network connectivity by means EEG proved to be useful in investigating changes occurring the information flow find correlation with function recovery. In literature, most studies applying post-stroke investigated undirected interacting brain regions. Quite recently, works started investigate directionality connections many approaches or features...
The effect of sustained fatigue during an upper limb isometric exercise is presented to investigate a group healthy subjects with simultaneous time-domain (TD) NIRS and surface electromyography (sEMG) recordings on the deltoid lateralis muscle. aim work was understand which TD-NIRS parameters can be used as descriptors for muscular fatigue, focusing slow phase this process using median frequency (MF) computed from sEMG gold standard measure. It found that oxygen saturation deoxy-hemoglobin...
We propose a quantitative and systematic investigation of the differential pathlength factor (DPF) behavior for skeletal muscles its dependence on different factors, such as subcutaneous adipose tissue thickness (ATT), variations absorption ( µ ) reduced scattering µ′ s coefficients, source-detector distance. A time domain (TD) NIRS simulation study is performed in two-layer geometry mimicking human muscle with an overlying layer. The DPF decreases when increases, while it increases...
Software programming is an acquired evolutionary skill originating from consolidated cognitive functions (i.e., attentive, logical, coordination, mathematic calculation, and language comprehension), but the underlying neurophysiological processes are still not completely known. In present study, we investigated compared brain activities supporting realistic programming, text code reading tasks, analyzing Electroencephalographic (EEG) signals 11 experienced programmers. Multichannel spectral...
The recovery of motor functions after stroke is fostered by the functional integration large-scale brain networks, including network (MN) and high-order cognitive controls such as default mode (DMN) executive control (ECN) networks. In this paper, electroencephalography signals are used to investigate interactions among these three resting state networks (RSNs) in subacute patients rehabilitation. A novel metric, O-information rate (OIR), quantify balance between redundancy synergy complex...
In time-domain diffuse optical spectroscopy, the simultaneous acquisition of time-of-flight distribution (DTOF) photons traveling in a diffusive medium and instrument response function (IRF) is necessary to perform quantitative measurements properties (absorption reduced scattering coefficients) while taking into account non-idealities real system ( e.g. temporal resolution time delays). The IRF can be non-trivial time-consuming operation that requires directly facing injection collection...
A high power setup for multichannel time-domain (TD) functional near infrared spectroscopy (fNIRS) measurements with efficiency detection system was developed. It fully characterized based on international performance assessment protocols diffuse optics instruments, showing an improvement of the signal-to-noise ratio (SNR) respect to previous analogue devices, and allowing acquisition signals sampling rate up 20 Hz source-detector distance 5 cm. resting-state measurement motor cortex a...
Understanding brain dynamics during motor tasks is a significant challenge in neuroscience, often limited to studying pairwise interactions. This study provides comprehensive hierarchical characterization of node-specific, and higher-order interactions within the human brain's network handgrip task execution. The source activity was reconstructed from scalp EEG signals ten healthy subjects performing task, identifying five regions contralateral ipsilateral networks. Using spectral entropy...
To investigate the potential of texture analysis applied on T2-w and postcontrast T1-w images acquired before radiotherapy for prostate cancer (PCa) 12 months after its completion in quantitatively characterizing local radiation effect muscular component internal obturators, as organs potentially involved urinary toxicity.T2-w MR were at 1.5 T treatment (MRI1) follow-up (MRI2) 13 patients treated with PCa. Right left obturator muscle contours manually delineated upon MRI1 then automatically...
Measuring muscle fatigue and resistance to is a topical theme in many clinical research studies. Multi-domain approaches, including electromyography (EMG), are employed measure rehabilitation contexts. In particular, spectral features, such as the reduction median frequency, accepted biomarkers detect conditions. However, applications of detection scenarios still limited with margin for improvement. One potential methodology clinics concerns evaluation after hip fracture. this work, 20...
Abstract In this paper, we used time-domain functional near infrared spectroscopy (TD-fNIRS) to evaluate the haemodynamic response function (HRF) in occipital cortex following visual stimulation glaucomatous eyes as compared healthy eyes. A total of 98 subjects were enrolled study and clinically classified subjects, glaucoma patients (primary open-angle glaucoma) mixed (i.e. with a different classification for two eyes). After quality check data from HRF 73 62 The amplitudes oxygenated...
Understanding brain dynamics during motor tasks is a significant challenge in neuroscience, often limited to studying pairwise interactions. This study provides comprehensive hierarchical characterization of node-specific, and higher-order interactions within the human brain's network handgrip task execution. Methods: The cortical activity was reconstructed from scalp EEG signals ten healthy subjects performing task, identifying five regions contralateral ipsilateral networks. Using spectral...