A5003101702- Optical Imaging and Spectroscopy Techniques
- Non-Invasive Vital Sign Monitoring
- Photoacoustic and Ultrasonic Imaging
- Infrared Thermography in Medicine
- Muscle activation and electromyography studies
- Spectroscopy Techniques in Biomedical and Chemical Research
- EEG and Brain-Computer Interfaces
- Heart Rate Variability and Autonomic Control
- Hemodynamic Monitoring and Therapy
- Cardiovascular and exercise physiology
- Advanced Optical Sensing Technologies
- Glaucoma and retinal disorders
- Acute Ischemic Stroke Management
- Digital Radiography and Breast Imaging
- Thermoregulation and physiological responses
- Stroke Rehabilitation and Recovery
- Additive Manufacturing and 3D Printing Technologies
- 3D Printing in Biomedical Research
- Transcranial Magnetic Stimulation Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Advanced MRI Techniques and Applications
- Calibration and Measurement Techniques
- Electrical and Bioimpedance Tomography
- Functional Brain Connectivity Studies
- Neuroscience and Neural Engineering
Istituto di Fotonica e Nanotecnologie
2019-2025
Politecnico di Milano
2016-2025
Consorzio Roma Ricerche
2024
National Research Council
2019-2023
University of Pavia
2020
The nEUROPt protocol is one of two new protocols developed within the European project to characterize performances time-domain systems for optical imaging brain. It was applied in joint measurement campaigns compare various instruments and assess impact technical improvements. This addresses characteristic brain detect, localize, quantify absorption changes implemented with types inhomogeneous liquid phantoms based on Intralipid India ink well-defined properties. First, small black...
A method for the discrimination of superficial and deep absorption variations by time domain functional near infrared spectroscopy is presented. The exploits estimate photon time-dependent pathlength in different domains sampled medium makes use an approach based on time-gating distribution time-of-flights. Validation performed two-layer geometry to focus muscle head applications. Numerical simulations varied thickness upper layer, interfiber distance, shape instrument response function...
We have designed a compact dual wavelength (687 nm, 826 nm) multi-channel (16 sources, 8 detectors) medical device for muscle and brain imaging based on time domain functional near infrared spectroscopy. The system employs the space multiplexing approach to reduce cross-talk increase signal-to-noise ratio. System performances been tested homogeneous heterogeneous tissue phantoms following specifically protocols photon migration instruments. Preliminary in vivo measurements performed validate...
Abstract Much of a child’s early learning takes place during social interactions with others. Neural synchrony, the temporal alignment individuals’ functional brain activity, is neural mechanism that may support successful interaction, but its biological origins and sensitivity to environmental factors remain unknown. This study measures coherence between 4- 6-year-old children their mothers using wearable near-infrared spectroscopy (“fNIRS”) in collaborative problem-solving hyperscanning...
A mechanically switchable solid inhomogeneous phantom simulating localized absorption changes was developed and characterized. The homogeneous host made of epoxy resin with black toner titanium dioxide particles added as absorbing scattering components, respectively. cylindrical rod, movable along a hole in the block same material, has polyvinyl chloride cylinder embedded its center. By varying volume position inclusion, perturbations can be generated over large range magnitudes. been...
We report the development of a compact probe for time-domain (TD) functional near-infrared spectroscopy (fNIRS) based on fast silicon photomultiplier (SiPM) that can be put directly in contact with sample without need optical fibers light collection. integrated an avalanche signal amplification stage close to SiPM, thus reducing size detection channel and optimizing immunity electromagnetic interferences. The whole electronics was placed plastic screw holder compatible electroencephalography...
Neuroimaging studies have shown neuromuscular electrical stimulation (NMES)-evoked movements activate regions of the cortical sensorimotor network, including primary cortex (SMC), premotor (PMC), supplementary motor area (SMA), and secondary somatosensory (S2), as well prefrontal (PFC) known to be involved in pain processing. The aim this study, on nine healthy subjects, was compare network activation profile ratings during NMES right forearm wrist extensor muscles at increasing current...
Measurement of muscle oxidative metabolism is interest for monitoring the training status in athletes and rehabilitation process patients. Time domain near infrared spectroscopy (TD NIRS) an optical technique that allows non-invasive measurement hemodynamic parameters muscular tissue: concentrations oxy- deoxy-hemoglobin, total hemoglobin content, tissue oxygen saturation. In this paper, we present a novel TD NIRS medical device metabolism. A custom-printed 3D probe, able to host elements...
The interest for Fused Deposition Modelling (FDM) in the field of Diffuse Optics (DO) is rapidly increasing. most widespread FDM materials are polylactic acid (PLA) and acrylonitrile butadiene styrene (ABS), thanks to their low cost easiness-to-print. This why, this study, 3D printed samples PLA ABS were optically characterized range from UV up IR wavelengths, order test possible employment probe construction DO applications. To purpose, measurements with Near Infrared Spectroscopy...
Significance: Multi-laboratory initiatives are essential in performance assessment and standardization—crucial for bringing biophotonics to mature clinical use—to establish protocols develop reference tissue phantoms that all will allow universal instrument comparison. Aim: The largest multi-laboratory comparison of near-infrared diffuse optics is presented, involving 28 instruments 12 institutions on a total eight experiments based three consolidated (BIP, MEDPHOT, NEUROPT) as implemented...
This review is an introduction to functional near infrared spectroscopy techniques and instrumentation which are commonly used for the estimation of haemoglobin concentration in muscle brain cortex. Three approaches considered: continuous wave, frequency domain time spectroscopy. The different briefly analysed from a theoretical point view order understand their capabilities drawbacks. Some considered, presenting main characteristics techniques, similarities principal differences.
The reproducibility of cerebral time-domain near-infrared spectroscopy (TD-NIRS) has not been investigated so far.Besides, reference intervals optical properties, absolute concentrations deoxygenated-hemoglobin (HbR), oxygenatedhemoglobin (HbO), total hemoglobin (HbT) and tissue oxygen saturation (StO 2 ) their variability have reported.We addressed these issues on a sample 88 adult healthy subjects.TD-NIRS measurements at 690, 785, 830 nm were fitted with the diffusion model for...
Time-domain diffuse correlation spectroscopy (TD-DCS) has been introduced as an advancement of the "classical" continuous wave DCS (CW-DCS) allowing one to not only measure depth-resolved blood flow index (BFI) but also extract optical properties measured medium without using any additional optics technique. However, this method is a photon-starved technique, specially when considering late photons that are primary interest which limited its in vivo application. In work, we present TD-DCS...
Large vessel occlusion (LVO) stroke might cause different degrees of hemodynamic impairment that affects microcirculation and contributes to metabolic derangement. Time-domain near-infrared spectroscopy (TD-NIRS) estimates the oxygenation cerebral outer layers. We measure hemoglobin species tissue oxygen saturation ( StO2 ) anterior circulation patients, classified as LVO or lacunar, assess differences compared with controls according recanalization status. Fiducial markers categorize brain...
The effect of sustained fatigue during an upper limb isometric exercise is presented to investigate a group healthy subjects with simultaneous time-domain (TD) NIRS and surface electromyography (sEMG) recordings on the deltoid lateralis muscle. aim work was understand which TD-NIRS parameters can be used as descriptors for muscular fatigue, focusing slow phase this process using median frequency (MF) computed from sEMG gold standard measure. It found that oxygen saturation deoxy-hemoglobin...
We designed and developed a compact dual-wavelength dual-channel time-resolved system for near-infrared spectroscopy studies of muscle brain. The employs pulsed diode lasers as sources, photomultipliers, time-correlated single photon counting boards detection. To exploit the full temporal dynamic range acquisition technique, we implemented an approach based on wavelength space multiplexing: laser pulses at two wavelengths are alternatively injected into channels by means optical 2×2 switch....
Continuous wave near infrared spectroscopy (CW-NIRS) is widely exploited in clinics to estimate skeletal muscles and brain cortex oxygenation. Spatially resolved (SRS) generally implemented commercial devices. However, SRS suffers from two main limitations: the a priori assumption on spectral dependence of reduced scattering coefficient [μs'(λ)] modeling tissue as homogeneous.We studied accuracy robustness NIRS. We investigated errors retrieving hemodynamic parameters, particular oxygen...
In order to study hemodynamic changes involved in muscular metabolism by means of time domain fNIRS, we need discriminate the measured signal contributions coming from different depths. Muscles are, fact, typically located under other tissues, e.g. skin and fat. this paper, possibility exploit a previously proposed method for analyzing time-resolved fNIRS measurements two-layer structure with thin superficial layer. This is based on calculation time-dependent mean partial pathlengths. We...
We propose a quantitative and systematic investigation of the differential pathlength factor (DPF) behavior for skeletal muscles its dependence on different factors, such as subcutaneous adipose tissue thickness (ATT), variations absorption ( µ ) reduced scattering µ′ s coefficients, source-detector distance. A time domain (TD) NIRS simulation study is performed in two-layer geometry mimicking human muscle with an overlying layer. The DPF decreases when increases, while it increases...
Software programming is an acquired evolutionary skill originating from consolidated cognitive functions (i.e., attentive, logical, coordination, mathematic calculation, and language comprehension), but the underlying neurophysiological processes are still not completely known. In present study, we investigated compared brain activities supporting realistic programming, text code reading tasks, analyzing Electroencephalographic (EEG) signals 11 experienced programmers. Multichannel spectral...
We propose a new algorithm, based on linear regression model, to statistically estimate the hemodynamic activations in fNIRS data sets.The main concern guiding algorithm development was minimization of assumptions and approximations made dataset for application statistical tests.Further, we K-means method cluster (i.e.channels) as activated or not activated.The methods were validated both simulated vivo data.A time domain (TD) technique preferred because its high performances discriminating...