Development of "smart" noninvasive bioimaging probes for trapping specific enzyme activities is highly desirable cancer therapy in vivo. Given that β-galactosidase (β-gal) an important biomarker cell senescence and primary ovarian cancers, we design enzyme-activatable ratiometric near-infrared (NIR) probe (DCM-βgal) the real-time fluorescent quantification β-gal activity vivo situ. DCM-βgal manifests significantly turn-on NIR signals simultaneously response to concentration, which makes it...

Abstract The rational design of high‐performance fluorescent materials for cancer targeting in vivo is still challenging. A unique molecular strategy presented that involves tailoring aggregation‐induced emission (AIE)‐active organic molecules to realize preferable far‐red and NIR fluorescence, well‐controlled morphology (from rod‐like spherical), also tumor‐targeted bioimaging. shape‐tailored quinoline–malononitrile (QM) nanoprobes are biocompatible highly desirable cell‐tracking...

We describe an enzyme-regulated liberation strategy to <italic>in situ</italic> generate AIEgen nanoaggregates for on-site sensing and long-term tracking of β-galactosidase in ovarian cancer cells.

The fluorescence of luminescent emitters is often quenched in the solid state, because typical aggregation-caused quenching (ACQ) effect, which a thorny obstacle to high-performance organic optoelectronic materials. exploration solid-state enhanced long wavelength, red-emitting chromophores, especially possessing one-dimensional (1D) assembly features, great importance. Interestingly, an excellent red emission system (denoted as ED) based on quinolinemalononitrile has been developed via...

Water-soluble, long wavelength fluorescent aggregation-induced emission (AIE)-active materials are in great demand for high contrast biosensing and bioimaging. The substitution position effects of the sulfonate group on basis two quinoline-malononitrile (QM) derivatives (EDS EDPS) provide insight into efficient modulation hydrophilicity, emitting color, specific AIE characteristics. EDS shows a unique behaviour aqueous solution, but EDPS does not. abnormal non-fluorescence aggregation pure...

The modulation of π-conjugated electrons in cyanine dyes can result a ratiometric fluorescence change with large Stokes shift (270 nm), especially for realizing palladium detection aqueous samples using indicator paper and living cells by mode.

Abstract The rational design of high‐performance fluorescent materials for cancer targeting in vivo is still challenging. A unique molecular strategy presented that involves tailoring aggregation‐induced emission (AIE)‐active organic molecules to realize preferable far‐red and NIR fluorescence, well‐controlled morphology (from rod‐like spherical), also tumor‐targeted bioimaging. shape‐tailored quinoline–malononitrile (QM) nanoprobes are biocompatible highly desirable cell‐tracking...

The option of conjugated π-linkers is critical for molecular engineering toward the energy-level strategy donor−π–acceptor (D−π–A) sensitizers. There always a balance in optimization π-linker. π-conjugation should be enlarged to expand light-harvesting capability sensitizers an increase photocurrent; however, oversized π-linker also would affect seriously photovoltage and photostability. Two sensitizers, WS-22 WS-23, are constructed without or with benzothiadiazole (BTD) skeleton, aiming...

Quinoxaline derivatives show great potential in recent organic photovoltaics, not only as polymer acceptors for bulk heterojuction (BHJ) solar cells but also molecular sensitizers dye-sensitized (DSSCs). This work focuses on the effect of π-linkers photovoltatic performances D–A−π–A quinoxaline-based used DSSCs. The extension is one viable tactics to improve molar absorption coefficient and red-shift peak, which beneficial light harvesting. With respect IQ4, a series quinoxaline IQ6, IQ7,...

A photochromic bisthienylethene derivative (BIT) containing two imidazole units has been synthesized and fully characterized. When triggered by chemical ions (Ag+), protons, light, BIT can behave as an absorbance switch, leading to a multiaddressable system. exhibits sequence-dependent responses via efficient interaction of the specific unit with protons Ag+. Furthermore, INHIBIT logic gate keypad lock three inputs are constructed unimolecular platform employing absorption mode at different...

The donor-acceptor system of indoline-benzothiadiazole is established as the novel and reactive platform for generating amine radical cations with interaction Cu(2+), which has been successfully exploited building block to be highly sensitive selective near infrared (NIR) colorimetric fluorescent Cu(2+) sensors. Upon addition an instantaneous red shift absorption spectra well quenched NIR fluorescence substrates observed. feasibility validity cation generation are confirmed by cyclic...

Objective This study aims to construct a predictive model based on machine learning algorithms assess the risk of prolonged hospital stays post-surgery for colorectal cancer patients and analyze preoperative postoperative factors associated with extended hospitalization. Methods We prospectively collected clinical data from 83 patients. The included 40 variables (comprising 39 predictor 1 target variable). Important were identified through variable selection via Lasso regression algorithm,...

The development of innovative strategies for high-performance near-infrared (NIR) fluorescent materials is in urgent demand bioimaging. By replacing the stronger electron-withdrawing groups or extending π-conjugated system, novel NIR DCM analogues have been developed, along with several striking characteristics: bright fluorescence over 700 nm, large Stokes shift and good photo-stability. It demonstrated that introducing a unit to acceptor moiety favourably efficient strategy tune prolong...

Background Accumulating observational studies have indicated that vitamin D deficiency (serum 25-hydroxyvitamin (25OHD) &amp;lt; 50 nmol/L) is common in women with polycystic ovary syndrome (PCOS). However, the direction and causal nature remain unclear. In this study, we aimed to investigate association between PCOS 25OHD. Methods A bidirectional two-sample Mendelian randomization (MR) study was used evaluate From publicly available European-lineage genome-wide (GWAS) summary statistics for...

A rational design of turn-on fluorescent chemosensors for monitoring α-ketoglutaric acid has been developed with a microfluidic chip, indicative potential platform high-throughput screening and kinetics, especially in biological fields.

Abstract MicroRNAs (miRNAs) have been demonstrated to affect the biological processes of cancers and showed great potential for prognostic biomarkers. In this study, we screened differentially expressed miRNAs in ccRCC based on three dimensions metastasis, prognosis, differential expression compared normal tissue using bioinformatics algorithms. MiR-153-5p was identified as a candidate miRNA promote occurrence progression. Clinically, found that miR-153-5p significantly upregulated related...

Abstract Therapeutic agents are urgently needed for treating metastatic castration‐refractory prostate cancer ( mCRPC ) that is unresponsive to androgen deprivation and chemotherapy. Our screening assays demonstrated chemotherapy‐resistant PC a) cells more sensitive HDAC inhibitors than paired a cells, as by cell proliferation apoptosis in vitro vivo . Kinetic study revealed TSA ‐induced was significantly dependent on enhanced transcription protein synthesis an early stage, which...

Activin A promotes human trophoblast invasion during the first trimester of pregnancy and is associated with preeclampsia pregnancy-induced hypertension (PE/PIH) in naturally conceived pregnancies. However, whether integrin β1 mediates activin A-increased remains unknown evidence limited regarding predictive value for PE/PIH women receiving vitro fertilization (IVF) treatment. Here, we studied role underlying molecular mechanisms A-promoted immortalized (HTR8/SVneo) primary extravillous...

To optimize light harvesting capabilities, one or two indoline units are introduced as additional donors into the traditional D−π–A model and constructed D–D−π–A sensitizers, CQ2 CQ3. Absorption spectra cyclic voltammetry performed to evaluate influence of different donor configurations on photophysical electrochemical properties well photovoltaic performances. Incorporating strong electron-donating unit an in CQ3 brings several characteristics, such improving visible light-harvesting...

A nanomized NIR fluorescent prodrug was developed with improved bioavailability and tumor-targeting ability. Nanomized tumor-microenvironment-active DCM-S-GEM/PEG provides a novel approach to realize long real-time tracking of drug delivery activation process without systemic toxicity <italic>in vivo</italic>.