A5002323224- Plant-Microbe Interactions and Immunity
- Cardiac Fibrosis and Remodeling
- Plant Pathogens and Resistance
- Plant Pathogenic Bacteria Studies
- Circadian rhythm and melatonin
- Cardiovascular Function and Risk Factors
- Plant Virus Research Studies
- Signaling Pathways in Disease
- Cardiac Imaging and Diagnostics
- Neurobiology and Insect Physiology Research
- Topic Modeling
- Olfactory and Sensory Function Studies
- Speech and dialogue systems
- Congenital heart defects research
- Cancer survivorship and care
- Fish Ecology and Management Studies
- Natural Language Processing Techniques
- Acute Myocardial Infarction Research
- Acupuncture Treatment Research Studies
- Pulmonary Hypertension Research and Treatments
- Hippo pathway signaling and YAP/TAZ
- Infectious Disease Case Reports and Treatments
- Cancer-related cognitive impairment studies
- Glycogen Storage Diseases and Myoclonus
- Pediatric Urology and Nephrology Studies
Army Medical University
2022-2024
Daping Hospital
2022-2024
Southwest Hospital
2024
Northwest A&F University
2020-2024
University of Copenhagen
2024
Mianyang Central Hospital
2024
University of Electronic Science and Technology of China
2024
Lanzhou University
2024
Children’s Hospital of Fudan University Xiamen Branch
2021-2022
Zero to Three
2022
Summary Pathogens secret a plethora of effectors into the host cell to modulate plant immunity. Analysing role in altering function their target proteins will reveal critical components immune system. Here we show that Phytophthora infestans RXLR effector PITG20303, virulent variant AVRblb2 (PITG20300) escapes recognition by resistance protein Rpi‐blb2, suppresses PAMP‐triggered immunity (PTI) and promotes pathogen colonization targeting stabilizing potato MAPK cascade protein, StMKK1. Both...
Abstract Phytophthora species are destructive plant pathogens that cause significant crop losses worldwide. To understand susceptibility to oomycete and explore novel disease resistance strategies, we employed the Arabidopsis thaliana–Phytophthora parasitica model pathosystem screened for A. thaliana T‐DNA insertion mutant lines resistant P. . This led identification of 267‐31, which carries two sites in promoter region ethylene‐responsive factor 19 gene ( ERF019 ). Quantitative reverse...
Abstract Mitogen-activated protein kinase (MAPK) cascades play important roles in plant immunity. Previously, we reported that the potato StMKK1 negatively regulates Nicotiana benthamiana resistance to Phytophthora infestans . However, functions of immunity are unknown. To investigate different pathogens, such as late-blight pathogen P. , bacterial wilt Ralstonia solanacearum and gray-mold fungal Botrytis cinerea generated transgenic lines investigated response transformants destructive...
Potato is the third most important food crop worldwide. production suffers from severe diseases caused by multiple detrimental plant pathogens, and broad-spectrum disease resistance genes are rarely identified in potato. Here we potato non-specific lipid transfer protein StLTPa, which enhances species none-specific against various such as oomycete pathogen Phytophthora infestans, fungal pathogens Botrytis cinerea Verticillium dahliae, bacterial Pectobacterium carotovorum Ralstonia...
A cascade formed by phosphorylation events of mitogen-activated protein kinases (MAPKs) takes part in plant stress responses. However, the roles these MAPKs resistance potato (Solanum tuberosum) against Phytophthora pathogens is not well studied. Our previous work showed that a infestans RXLR effector targets and stabilizes negative regulator MAPK kinase 1 (StMKK1). Because Arabidopsis thaliana AtMPK4 downstream target AtMKK1, we performed phylogenetic analysis found StMPK4/6/7 are closely...
An experiment was conducted to determine effects of feeding levels on growth performance, feed utilization, nutrient deposition, body composition and apparent digestibility coefficients (ADCs) nutrients for juvenile Chinese sucker (initial weight, 11.77±0.22 g). were fed a practical diet from 0% (starvation) 4.0% (at 0.5% increments) weight (bw) day−1 8 weeks. The results showed that ADCs dry matter, protein energy significantly (P<0.05) affected by levels. Survival the lowest starvation...
Phytophthora infestans causes severe losses in potato production. The MAPK kinase StMKK1 was previously found to negatively regulate immunity P. infestans. Our results showed that interacts with a protein tyrosine phosphatase, referred as StPTP1a, and directly phosphorylates StPTP1a at residues Ser-99, Tyr-223 Thr-290. is functional phosphatase the phosphorylation of these three enhances its stability catalytic activity. regulates represses SA-related gene expression. Furthermore, with,...
Abstract Background GRACE risk score models are capable of predicting all-cause mortality non-ST elevation myocardial infarction (NSTEMI) patients. However, its utility for evaluating major adverse cardiovascular events (MACE) in NSTEMI patients with multivessel disease (MVD) remains unclear. Methods and results This study was designed as a retrospective cohort that recruited between September 2013 December 2018 Daping Hospital, Chongqing, China. The primary outcome composite included...
Abstract Mitogen‐activated protein kinase (MAPK) cascades play pivotal roles in plant responses to both biotic and abiotic stress. A screen of a Nicotiana benthamiana cDNA virus‐induced gene silencing (VIGS) library for altered inoculation with Phytophthora infestans previously identified an NbMKK gene, encoding clade D MAPKK that we renamed as NbMKK5 , which is involved immunity P. . To study the role potato orthologous referred StMKK5 response transiently overexpressed N. observed cell...
We present DeepSeek-VL2, an advanced series of large Mixture-of-Experts (MoE) Vision-Language Models that significantly improves upon its predecessor, DeepSeek-VL, through two key major upgrades. For the vision component, we incorporate a dynamic tiling encoding strategy designed for processing high-resolution images with different aspect ratios. language leverage DeepSeekMoE models Multi-head Latent Attention mechanism, which compresses Key-Value cache into latent vectors, to enable...
To explore the applicability of Tei index combined with lung ultrasound score (LUS) in evaluation condition and right ventricular function patients neonatal pulmonary hypertension (PH).Thirty healthy neonates 75 PH were included. Two-dimensional, M-mode, double Doppler used to detect RVFAC, TAPSE, TAPSV, (DD-Tei index). Intra-group correlation coefficient (ICC), Bland-Altman, Spearman rank method, ROC (receiver operating characteristic) for other objectives within study. LUS was or without...
Background: A high prevalence of infantile-onset Pompe disease (IOPD) in the Chinese population has been noted, but there are currently no reported clinical trials enzyme replacement therapy (ERT) for IOPD this population. The purpose study was to evaluate efficacy and safety alglucosidase alfa patients with IOPD. Materials Methods: multicentre, single-arm, prospective, open-label trial performed at 4 sites China. Eligible subjects received an infusion a dose 20 mg/kg every 2 weeks up 52...
Mitogen-activated protein kinase (MAPK) cascades play pivotal roles in regulating plant immunity. MAPKs usually transduce signals and regulate immunity by phosphorylating the downstream defence-related components. Our previous study indicates that StMPK7 positively regulates defence to Phytophthora pathogens via SA signalling pathway. However, component of remains unknown. In this study, we employed GFP-StMPK7 transgenic potato performed immunoprecipitation-mass spectrometry (IP-MS) identify...
Nonalcoholic fatty liver disease (NAFLD) is an emerging driver of cardiac arrhythmias. However, the relationship between NAFLD and malignant arrhythmia in non-ST-segment elevation myocardial infarction (NSTEMI) patients still unclear.In this study, 358 NSTEMI inpatients were enrolled. They all received 24-hour Holter monitoring after percutaneous coronary intervention. All divided into two groups: non-NAFLD group (236 cases, 65.9%) (122 34.1%). Compared with group, had a significantly higher...
Abstract Sickness-induced sleep is a behavior conserved across species that promotes recovery from illness, yet the underlying mechanisms are poorly understood. Here, we show interleukin-6-like cytokine signaling Drosophila gut to brain glial cells regulates sleep. Under healthy conditions, this pathway wakefulness. However, elevated in response oxidative stress – triggered by immune and inflammatory responses intestine induces The cytokines Unpaired 2 -3 upregulated enteroendocrine activate...
Sickness-induced sleep is a behavior conserved across species that promotes recovery from illness, yet the underlying mechanisms are poorly understood. Here, we show interleukin-6-like cytokine signaling Drosophila gut to brain glial cells regulates sleep. Under healthy conditions, this pathway wakefulness. However, elevated in response oxidative stress – triggered by immune and inflammatory responses intestine induces The cytokines Unpaired 2 -3 upregulated enteroendocrine activate JAK-STAT...
Sickness-induced sleep is a behavior conserved across species that promotes recovery from illness, yet the underlying mechanisms are poorly understood. Here, we show interleukin-6-like cytokine signaling Drosophila gut to brain glial cells regulates sleep. Under healthy conditions, this pathway wakefulness. However, elevated in response oxidative stress – triggered by immune and inflammatory responses intestine induces The cytokines Unpaired 2 -3 upregulated enteroendocrine activate JAK-STAT...
Background Cholangiocarcinoma is a malignancy with high aggressiveness, and extrahepatic cholangiocarcinoma (ECCA) represents the predominant subtype. However, molecular architecture underlying pathogenic mechanisms of ECCA remain poorly understood. The objective this study to elucidate markers biological pathways associated ECCA. Methods In order identify factors influencing ECCA, we conducted transcriptome sequencing on cohort 8 surgically resected specimens. To validate our findings,...
Prostatic malakoplakia is an uncommon chronic inflammatory disorder, tumor-like but non-cancerous, the diagnosis of which pivots crucially on identification characteristic Michaelis-Gutmann bodies within pathological tissue. We hereby present inaugural case report prostatic concurrent with sepsis caused by multidrug-resistant Escherichia coli, verified through blood culture and metagenomic next-generation sequencing (mNGS). The pathogenesis might be associated infections immune system...
We present JanusFlow, a powerful framework that unifies image understanding and generation in single model. JanusFlow introduces minimalist architecture integrates autoregressive language models with rectified flow, state-of-the-art method generative modeling. Our key finding demonstrates flow can be straightforwardly trained within the large model framework, eliminating need for complex architectural modifications. To further improve performance of our unified model, we adopt two...