A5022159619- Global Cancer Incidence and Screening
- Breast Cancer Treatment Studies
- Cancer Genomics and Diagnostics
- BRCA gene mutations in cancer
- Cancer survivorship and care
- Economic and Financial Impacts of Cancer
- Prostate Cancer Diagnosis and Treatment
- Health Systems, Economic Evaluations, Quality of Life
- Prostate Cancer Treatment and Research
- Bone health and treatments
- Patient-Provider Communication in Healthcare
- Healthcare Policy and Management
- Lung Cancer Diagnosis and Treatment
- Management of metastatic bone disease
- Colorectal Cancer Screening and Detection
- Genetic factors in colorectal cancer
- Childhood Cancer Survivors' Quality of Life
- Cancer Risks and Factors
- Statistical Methods in Clinical Trials
- Health disparities and outcomes
- Smoking Behavior and Cessation
- Migration, Health and Trauma
- Digital Radiography and Breast Imaging
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Lymphatic System and Diseases
National Institute on Minority Health and Health Disparities
2022-2025
National Institutes of Health
2022-2025
Decision Sciences (United States)
2024-2025
National Cancer Institute
2016-2024
Georgetown University Medical Center
2018-2022
Georgetown University
2016-2022
MedStar Georgetown University Hospital
2018-2022
University of Michigan
2022
Georgetown Lombardi Comprehensive Cancer Center
2020-2021
University of Maryland, Baltimore
2012-2018
Breast cancer mortality in the US declined between 1975 and 2019. The association of changes metastatic breast treatment with improved is unclear.
The effects of breast cancer incidence changes and advances in screening treatment on outcomes different strategies are not well known.
Guidelines recommend offering cessation interventions to smokers eligible for lung cancer screening, but there is little data comparing specific approaches in this setting. We compared the benefits and costs of different smoking help screening programs select approaches.
Abstract Background Lung cancer mortality is reduced via low-dose computed tomography screening and treatment of early-stage disease. Evidence-based smoking cessation in the lung setting can further reduce mortality. We report results a trial from National Cancer Institute’s Smoking Cessation at Examination collaboration. Methods Eligible patients (n = 818) aged 50-80 years were randomly assigned (May 2017-January 2021) to intensive vs minimal arms (8 3 phone sessions plus 8 2 weeks nicotine...
Purpose Gene expression profile (GEP) testing can support chemotherapy decision making for patients with early-stage, estrogen receptor–positive, human epidermal growth factor 2–negative breast cancers. This study evaluated the cost effectiveness of one GEP test, Onco type DX (Genomic Health, Redwood City, CA), in community practice test-eligible age 40 to 79 years. Methods A simulation model compared 25-year societal incremental costs and quality-adjusted life-years (QALYs) use from 2005...
Abstract Over the past 2 decades, population simulation modeling has evolved as an effective public health tool for surveillance of cancer trends and estimation impact screening treatment strategies on incidence mortality, including documentation persistent inequities. The goal this research was to provide a framework support next generation models identify leverage points in control continuum accelerate achievement equity care minoritized populations. In our framework, systemic racism is...
Abstract Purpose We evaluated healthcare providers’ current knowledge, practices, and perspectives on a novel clinical decision tool (beta-version) to facilitate individualized exercise prescriptions discussions in settings. Methods recruited providers who had treated or provided care breast cancer survivors aged ≥ 35-years the past 12 months. The participants were presented with provide recommendations considering women’s individual, clinical, contextual characteristics. Validated reliable...
ABSTRACT Background Guidelines recommend primary care practitioners (“PCPs”) engage women ≥ 75 years in shared decision‐making (SDM) around mammography screening. Therefore, we aimed to develop a web‐based conversation aid about screening for using output from established simulation models provide outcomes based on > 23,000 combinations of individual women's health and breast cancer risk factors. Methods We used an end‐user centered design approach prototype incorporating feedback. From...
Background. The Georgetown University-Albert Einstein College of Medicine breast cancer simulation model (Model GE) has evolved over time in structure and function to reflect advances knowledge about cancer, improvements early detection treatment technology, progress computing resources. This article describes the provides examples applications. Methods. is a discrete events microsimulation single-life histories women from multiple birth cohorts. Events are simulated absence screening...
Radiotherapy after breast conservation has become the standard of care. Prior meta-analyses on effects radiotherapy predated availability gene expression profiling (GEP) to assess recurrence risk and/or did not include all relevant outcomes. This analysis used GEP information with pooled individual-level data evaluate impact omitting and mortality.We considered trials that evaluated or administered lumpectomy in women low-risk cancer. Women included had undergone were treated hormonal...
Abstract Endocrine therapy for breast cancer may reduce the risk of contralateral (CBC). However, there are no published estimates quantifying lifetime outcomes by age at primary diagnosis, regimen, or duration. Here, we adapted an established Cancer Intervention and Surveillance Network (CISNET) model to simulate life histories multiple US female birth-cohorts diagnosed with stage 0-III ER+/HER2- receiving different durations (none, 2.5, 5, 10 years) two endocrine regimens (aromatase...
Importance Exercise may offer various clinical benefits to breast cancer survivors. However, exercise participation among survivors is low. Discussions about can increase participation, but details regarding implementation of communication for are unclear. Objective To examine the development and explicitly reported Evidence Review The Preferred Reporting Items Systematic reviews Meta-Analyses extension Scoping Reviews was used. Six databases (PubMed/MEDLINE, Cochrane Library, Embase, Web...
Abstract We aimed to estimate the incremental effects of post-diagnosis recreational aerobic exercise, and possible variations in effects, on recurrence mortality support individualized breast cancer survivorship care plans clinical settings. Seven databases were searched identify observational studies that examined exercise recurrence, cancer-specific (BCSM), all-cause (ACM) among female survivors. Fully adjusted hazard ratios, 95% confidence intervals extracted for comparisons reported...
e13715 Background: Current clinical guidelines recommend that clinicians provide individualized exercise prescriptions to cancer survivors. However, there are no decision tools support considering individual and demographic characteristics of breast We aimed gather survivors’ perspectives on a prototype tool in settings. Methods: A racially ethnically diverse sample survivors across the U.S. were recruited complete an online survey. Survey items adapted from validated pre-existing...
e23183 Background: Breast cancer survivors are at increased risk of poor health-related quality-of-life (HRQOL). Clinical trials suggest that physical activity may improve HRQOL among survivors. However, there limited data on the generalizability clinical trial findings to real-world settings. We aimed fill this gap by evaluating observational literature post-diagnosis recreational and breast Methods: A systematic review following Preferred Reporting Items for Systematic Reviews...
10517 Background: Current cancer physical activity guidelines recommend clinicians offer individualized ‘physical prescriptions’ to survivors. However, there are limited data support prescriptions for breast survivors in clinical settings. We aimed develop a simulation model-based ‘calculation engine’ decision tool that could generate outcomes associated with considering the individual characteristics of Methods: adapted an established and validated model developed within Cancer Intervention...