A5101775496- Systemic Lupus Erythematosus Research
- Monoclonal and Polyclonal Antibodies Research
- T-cell and B-cell Immunology
- Lymphoma Diagnosis and Treatment
- Viral Infections and Immunology Research
- Bladder and Urothelial Cancer Treatments
- Educational Reforms and Innovations
- Pediatric Hepatobiliary Diseases and Treatments
- Phagocytosis and Immune Regulation
- Cellular transport and secretion
- Urinary and Genital Oncology Studies
- Kidney Stones and Urolithiasis Treatments
- Facial Nerve Paralysis Treatment and Research
- Urinary Tract Infections Management
- CAR-T cell therapy research
- RNA and protein synthesis mechanisms
- Chronic Lymphocytic Leukemia Research
- Biliary and Gastrointestinal Fistulas
- Medical Research and Treatments
- Viral-associated cancers and disorders
- Peripheral Neuropathies and Disorders
- Peptidase Inhibition and Analysis
- SARS-CoV-2 and COVID-19 Research
- Gallbladder and Bile Duct Disorders
Xi'an Jiaotong University
2021-2024
Sichuan University
2022-2024
West China Hospital of Sichuan University
2024
Sun Yat-sen University Cancer Center
2023
Sun Yat-sen University
2023
West China Second University Hospital of Sichuan University
2022
Zunyi Medical University
2020
Heilongjiang University of Chinese Medicine
2015
Enterovirus 71 (EV71) is one of the major pathogens causing hand, foot, and mouth disease in children under 5 years old, which can result severe neurological complications even death. Due to limited treatments for EV71 infection, identification novel host factors elucidation mechanisms involved will help counter this viral infection. N-terminal acetyltransferase 6 (NAT6) was identified as an essential factor infection with genome-wide CRISPR/Cas9 screening. NAT6 facilitates replication...
Fulminant lupus myocarditis is a rare but fatal manifestation of systemic erythematosus. Aggressive immunosuppressive treatments are important in its successful management. However, they can significantly damage the immunity and associated with considerable risk infection development spread. We present complicated case 20-year-old female diagnosed fulminant accompanied by pneumonia. The patient was successfully treated plasma exchange (PE) for myocarditis.A Chinese woman presented to...
Background There is little data available on the role of new anti-reflux plastic stents (ARPSs). Aim To compare use ARPSs with that traditional (TPSs) for patients biliary strictures. Methods Consecutive strictures who underwent first endoscopic stenting between February 2016 and May 2019 were included. The onset stent-related cholangitis, stent patency, clinical success, other adverse events evaluated. Results Sixty-seven in ARPS group 66 TPS included final analyses. Fewer experienced...
Systemic lupus erythematosus (SLE) is a complex autoimmune disease characterized by multi-organ involvement and the presence of autoantibodies, pathogenic factors that can serve as diagnostic biomarkers. The current research has been focusing on exploring specific autoantigens with clinical relevance for SLE subtypes. In line this objective, study investigated potential antigenic targets associated phenotypes in leveraging an omics-based approach combined immunoassay techniques. A...
In a phase 1 dose escalating clinical trial, the tolerability and efficacy of HS006, recombinant human-mouse chimeric anti-CD20 monoclonal antibody, for treatment CD20 positive B-cell non-Hodgkin's lymphoma (NHL) was investigated.The dosage HS006 escalated in eligible patient groups at 250 mg/m 2 (n = 3), 375 4), 500 4) 625 3) doses, given once week as single-dose with 35-day follow-up, 4 multiple-doses 168-day follow-up.Dose-limiting toxicity (DLT) or maximum tolerated were not found.All...
Objective: To compare the efficacy of induction chemotherapy with or without autologous hematopoietic stem cell transplantation (auto-HSCT) for newly diagnosed young diffuse large B lymphoma (DLBCL) patients. Methods: The retrospective study was performed in 90 cases patients (≤60 years) DLBCL and an age-adjusted International Prognostic Index (aa-IPI) score 2 3. All them were treated R-CHOP (32 cases, rituximab combined CHOP), dose-intensive regimens (DA-EPOCH, Hyper CVAD/MA ESHAP) (25...
Abstract The recent COVID-19 pandemic poses a global health emergency. Cellular entry of the causative agent SARS-CoV-2 is mediated by its spike protein interacting with cellular receptor- human angiotensin converting enzyme 2 (ACE2). Here, we used lentivirus based pseudotypes bearing to demonstrate that into host cells dependent on clathrin-mediated endocytosis, and phosphoinositides play essential role during this process. In addition, showed intracellular domain catalytic activity ACE2...
Abstract Background: Biomarkers for diagnosis in neuropsychiatric systemic lupus erythematosus (NPSLE) are still lacking, we implemented this study to identify potential antigenic targets that associated with the pathogenic mechanism disease, combining transcriptomic and proteomics approach chemiluminescence immune assay. Methods: Transcriptomic analysis of 70 SLE patients or without involvement was carried out obtain NPSLE-related genes. Epitope mapping sequence were used predict...