A5100361309- Ovarian function and disorders
- Reproductive Biology and Fertility
- Endometriosis Research and Treatment
- Sperm and Testicular Function
- Assisted Reproductive Technology and Twin Pregnancy
- Reproductive System and Pregnancy
- Gynecological conditions and treatments
- Reproductive Health and Technologies
- Uterine Myomas and Treatments
- Ovarian cancer diagnosis and treatment
- Endometrial and Cervical Cancer Treatments
- Healthcare and Venom Research
- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Hormonal and reproductive studies
- Ectopic Pregnancy Diagnosis and Management
- Gestational Diabetes Research and Management
- Blood Coagulation and Thrombosis Mechanisms
- Testicular diseases and treatments
- Pharmacological Effects and Toxicity Studies
- Genetic Associations and Epidemiology
- Demographic Trends and Gender Preferences
- Male Reproductive Health Studies
- Plant Toxicity and Pharmacological Properties
- Heat shock proteins research
Qilu Hospital of Shandong University
2013-2025
South China Agricultural University
2024
Shuguang Hospital
2022-2023
Shanghai University of Traditional Chinese Medicine
2022-2023
Guangdong Province Women and Children Hospital
2009-2023
Chengdu Women's and Children's Central Hospital
2023
Affiliated Hospital of Liaoning University of Traditional Chinese Medicine
2021-2022
Shandong University of Traditional Chinese Medicine
2021-2022
Weatherford College
2020-2022
Second Hospital of Shandong University
2022
Large studies on semen quality of the general healthy population from China are rare.A cross-sectional study was performed to evaluate 1346 men residing in Chongqing area southwest 2007. The parameters were measured and compared with World Health Organization (WHO) criteria. A linear regression model used examine determinants quality.The medians 2.3 ml for volume, 77.8 x 10(6) per concentration, 167.7 total sperm count, 33% rapid progressive motility, 52.6% motility 70.9% motility. According...
Polycystic ovary syndrome (PCOS) is a heterogeneous endocrine disorder frequently accompanied by obesity and insulin resistance, patients with this suffer from infertility poor pregnancy outcome. Disturbances in plasma amino acid (AA) metabolism have been implicated women PCOS. However, direct evidence on follicular AA metabolic profiles PCOS their relationship outcome sparse. We conducted prospective study 63 48 controls the Division of Reproductive Center, Peking University Third Hospital....
To investigate the rare obstetric emergency with no specific treatments called acute fatty liver of pregnancy. The primary objective was to evaluate association adverse perinatal outcomes blood components transfusion. While secondary focused on further establishing predictive risk factors for outcomes. This retrospective cohort study included patients, who diagnosed pregnancy without hepatic/malignant diseases in Qilu Hospital Shandong University over 12-year period (collected 2007-2019,...
<b><i>Objectives:</i></b> To evaluate the clinical outcomes of gonadotropin-releasing hormone analog (GnRHa) combined with implantation a levonorgestrel-releasing intrauterine system (LNG-IUS) in adenomyosis patients significantly enlarged uteruses. <b><i>Subjects and Methods:</i></b> Twenty-one whose uterine volumes were greater size than at 12 weeks' gestation recruited for study. Subcutaneous injection GnRHa was administrated an interval 28...
N -acetyl-cysteine (NAC) is a potent antioxidant that can be used for many gynecological diseases such as polycystic ovary syndrome and endometriosis. Controlled ovarian hyperstimulation (COH) critical step in infertility treatment. Our previous clinical studies have shown repeated COH led to oxidative stress follicle fluid granulosa cells.In this study, we investigated whether NAC could inhibit mice caused by improve the mitochondrial function of oocytes.Female Institute Cancer Research...
Polycystic ovary syndrome (PCOS) is a heterogenetic disorder in women that characterized by arrested follicular growth and anovulatory infertility. The altered protein expression levels the ovarian tissues reflect molecular defects folliculogenesis. To identify aberrant PCOS, we analyzed profiles of patients with PCOS. We identified total 18 spots were differentially expressed PCOS compared healthy samples. A 13 proteins upregulated 5 downregulated. heat shock 90B1 (HSP90B1) calcium...
To identify differential protein expression pattern associated with polycystic ovary syndrome (PCOS).Twenty women were recruited for the study, ten PCOS as a test group and without control group. Differential in-gel electrophoresis (DIGE) analysis mass spectroscopy employed to proteins that differentially expressed between normal ovaries. The further validated by western blot (WB) immunohistochemistry (IHC).DIGE revealed eighteen in ovaries of which thirteen upregulated, five downregulated....
The aim of the present study was to identify potential serum biomarkers for insulin resistance (IR) in patients with polycystic ovary syndrome (PCOS) by comparing differences protein expression levels between PCOS and without IR. aged from 18 35 years were recruited at Guangdong Women Children's Hospital January, 2013 February, 2014. A total 218 enrolled divided into (PCOS‑IR) non‑insulin (PCOS‑NIR) groups according their homeostasis model assessment resistance. Two‑dimensional difference...
Background Polycystic ovary syndrome (PCOS) not only increases fertility challenges for women of reproductive age, but also leads to increased complications during pregnancy and even affects the birth weight newborns. Also, hyperandrogenemia is associated with lower rates live may play a role in preterm delivery pre-eclampsia patients PCOS. However, it still controversial whether PCOS are treated androgen-lowering therapy before pregnancy. Objective To assess effect anti-androgen prior...
Purpose: To investigate the influence of cytochrome P450 17α (CYP17A1) gene -34T/C polymorphism in pathogenesis polycystic ovary syndrome (PCOS) Han Chinese population.Methods: Three-hundred eighteen patients with PCOS and 306 controls were recruited CYP17A1 was genotyped using polymerase chain reaction-restriction fragment length (PCR-RFLP). Furthermore, relationship clinical feature parameters also analyzed.Results: The prevalence rates genotype TT, TC CC 49.69%, 43.71% 6.6% case group...
Objective: The principal purpose of this study was to compare reproductive outcomes for stimulated cycles (STC) and hormone replacement (HRC) endometrial preparation before frozen-thawed embryo transfer (FET) in young women with polycystic ovary syndrome (PCOS). Methods: We conducted a retrospective 1434 FET from January, 2017 March, 2020 our center, which were used preparation. Pregnancy couples undergoing routine STC-FET or HRC-FET analyzed by propensity score matching (PSM) multivariable...
Objective: The aim of this study is to investigate, in ovulatory patients, whether there a difference reproductive outcomes following frozen-thawed embryo transfer (FET) natural cycles (NC) compared modified (mNC). Methods: This retrospective cohort study, performed at the public tertiary fertility clinic, involved all infertile patients undergoing endometrial preparation prior FET NC and mNC from January, 2017 November, 2020. One thousand hundred sixty-two were divided into two groups:...
Abstract Background To investigate the effectiveness and safety of 3 mg drospirenone 20 μg ethinyl estradiol tablet (3 DRSP/20 EE) in treatment polycystic ovary syndrome (PCOS). Methods This single center, prospective observational study was conducted 140 patients with PCOS. They were prescribed EE a 24/4/ regimen for months. Patients instructed to take oral DRSP/EE tablets (once daily) on 2nd day menstruation, 28 consecutive days 1 cycle. After months treatment, anthropometric assessments...
Herein, we aimed to analyse the effects of body mass index (BMI) on treatment outcomes in vitro fertilisation (IVF) a cohort women undergoing their first IVF cycle.A total 2311 cycles from 986 IVF/intracytoplasmic sperm injection cycle with fresh/frozen embryo transfer between January 2018 and December 2021 at Center Reproductive Medicine, Shuguang Hospital affiliated Shanghai University Traditional Chinese were considered this retrospective study. First, included patients classified into...
Polycystic ovary syndrome (PCOS) is a common disorder in women that shares many genetic features with type 2 diabetes mellitus. Novel risk loci for diabetes, single nucleotide polymorphism (SNP) rs7756992 cyclin-dependent kinase 5 (CDK5) regulatory subunit associated protein 1-like 1 (CDKAL1), rs290487 and rs11196218 transcription factor 7-like (TCF7L2), were recently identified. The aim of this study was to test whether these are also PCOS. We recruited 826 patients PCOS 620 healthy...
Sperm DNA fragmentation and its adverse impact on outcomes of assisted reproductive techniques (ART) in globozoospermic infertile patients has been previously reported. However, the association Zinc element with damage intracytoplasmic sperm injection (ICSI) outcome remains unclear.Using flame atomic absorption spectrophotometer superoxide dismutase (SOD) assay, levels Cu, Fe, Mn, Zn SOD activities seminal plasma from both fertile volunteers were tested respectively. Using chromatin...