A5039849405- Reproductive System and Pregnancy
- Reproductive Biology and Fertility
- Ovarian function and disorders
- Endometriosis Research and Treatment
- Medicinal Plant Pharmacodynamics Research
- Healthcare and Venom Research
- Pregnancy and preeclampsia studies
- Growth Hormone and Insulin-like Growth Factors
- Menstrual Health and Disorders
- Traditional Chinese Medicine Studies
- Cancer-related molecular mechanisms research
- Bone Metabolism and Diseases
- Cancer, Hypoxia, and Metabolism
- Lipid metabolism and disorders
- Phytochemical and Pharmacological Studies
- Hydrogen's biological and therapeutic effects
- Sperm and Testicular Function
- Amyotrophic Lateral Sclerosis Research
- Tissue Engineering and Regenerative Medicine
- Free Radicals and Antioxidants
- Angiogenesis and VEGF in Cancer
- Circular RNAs in diseases
- Endometrial and Cervical Cancer Treatments
- Caveolin-1 and cellular processes
- Pregnancy-related medical research
Hebei University of Chinese Medicine
2015-2024
Hebei Medical University
2004-2022
N -acetyl-cysteine (NAC) is a potent antioxidant that can be used for many gynecological diseases such as polycystic ovary syndrome and endometriosis. Controlled ovarian hyperstimulation (COH) critical step in infertility treatment. Our previous clinical studies have shown repeated COH led to oxidative stress follicle fluid granulosa cells.In this study, we investigated whether NAC could inhibit mice caused by improve the mitochondrial function of oocytes.Female Institute Cancer Research...
Vascular endothelial growth factor receptor-2 (VEGFR-2) regulates the mitogen-activated protein kinase (MAPK) signaling pathway and plays an important role in angiogenesis. Bu Shen Zhu Yun decoction (BSZYD) can improve endometrial receptivity embryo implantation rates patients undergoing vitro fertilization. However, whether BSZYD improves via angiogenesis remains unclear. Here, we investigated effects of on proliferation, migration, human microvascular cells (HEMECs) found that upregulated...
Morroniside is the main ingredient of
Long non‑coding RNA forkhead box D3 antisense 1 (FOXD3‑AS1) functions as an oncogenic regulator in several types of cancer, including breast glioma and cervical cancer. However, the effects mechanisms underlying FOXD3‑AS1 cancer (CC) are not completely understood. The present study aimed to investigate biological potential molecular CC progression. Reverse transcription‑quantitative PCR was performed detect FOXD3‑AS1, microRNA (miR)‑128‑3p LIM domain kinase (LIMK1) expression levels tissues...
During embryo implantation, the blastocyst exhibits a high capacity for aerobic glycolysis, which results in unique microenvironment of lactate/low pH at maternal-fetal interface. Shoutai Wan (STW) is an effective Chinese herbal formula widely used clinical treatment recurrent spontaneous abortion (RSA). However, specific molecular mechanism by STW prevents yet to be elucidated.Female CBA/J mice were allocated into six groups randomly and then mated with BALB/c as control group, DBA/2 RSA...
To observe the effects of Bushenwenyanghuayu decoction (BD), a Traditional Chinese Medicine (TCM), on serum concentration nerve growth factor (NGF) and bradykinin (BK), protein mRNA levels NGF B1 receptor (BKB1R) in mouse model endometriosis dysmenorrhea. Seventy-five experimental female BALB/c mice were randomly divided into five groups, 15 each: sham, model, BD high dose (61.67 g/kg), low (15.42 gestrinone (0.4 mg/kg) groups. All except for those sham group underwent auto-transplantation...
To investigate the effect of Soothing liver therapy on infertile women undergoing in vitro fertilization and embryo transfer (IVF-ET) to explore its mechanism.Fifty-eight with tubal infertility were randomized into two groups: 30 an experimental group treated Xiaoyao powder (Shugan) plus gonadotropin-releasing hormone analog (GnRHa)/follicle-stimulating (FSH)/ human chorionic gonadotropin (hCG) 28 control who GnRHa/FSH/ hCG only. The total (Gn) doses required, endometrial thickness, oocyte...
Bone morphogenetic protein-6 (BMP-6), which is a member of the transforming growth factor-β superfamily, associated with regulation bone development and various physiological processes. In present study, expression BMP-6 in follicular fluid granulosa cells (GCs) from pregnant non-pregnant patients was explored. A total 44 (pregnant group) 36 (non-pregnant were recruited for study. The detected using western blotting reverse transcription-quantitative polymerase chain reaction. significantly...
Abstract Bushen-Tiaojing-Fang (BSTJF) is commonly used to treat infertility. This study investigated the effects of BSTJF on pregnancy outcomes patients with repeated controlled ovarian stimulation (COS), mitochondrial function, and oxidative stress in granulosa cells (GCs) follicular fluid (FF). The samples clinical data 97 patients, including 35 control group, 29 placebo group 33 were collected for this study. ultrastructure, ATP content, DNA (mtDNA) number, 8-hydroxy-2-deoxyguanosine...
Kidney-tonifying formulas are frequently used in clinical practices to enhance follicular development and maturation. This research explored the impacts of Bushen Tiaojing formula (BSTJF) on mouse preantral follicles
Abstract Background Morroniside is the main ingredient of Cornus officinalis, which has an antioxidant effect. Ovarian granulosa cells (GCs) are responsible for regulating development and atresia follicles, susceptible to oxidative stress. In this study, we investigated whether morroniside could inhibit stress GCs induced by hydrogen peroxide (H 2 O ), thus leading improve oocyte quality. Methods The study was divided into 5 groups: control group, H (5 µM) + , (10 (20 . Cell survival rate...