A5014454411- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Sexual Differentiation and Disorders
- Diet and metabolism studies
- Cancer-related molecular mechanisms research
- Cancer, Hypoxia, and Metabolism
- Cardiovascular Disease and Adiposity
- Liver Disease Diagnosis and Treatment
- Metal complexes synthesis and properties
- Metabolism and Genetic Disorders
- Circular RNAs in diseases
- Metabolomics and Mass Spectrometry Studies
- Bariatric Surgery and Outcomes
- Alkaline Phosphatase Research Studies
- Metabolism, Diabetes, and Cancer
- Cardiovascular Health and Disease Prevention
- bioluminescence and chemiluminescence research
- Adipokines, Inflammation, and Metabolic Diseases
- Genomics and Rare Diseases
- Hedgehog Signaling Pathway Studies
- Peripheral Artery Disease Management
- Circadian rhythm and melatonin
- Nutrition, Genetics, and Disease
- Cancer Risks and Factors
- Biochemical and Molecular Research
Zhengzhou Children's Hospital
2019-2025
Zhengzhou University
2018-2024
Cangzhou Central Hospital
2015-2021
Women's Hospital, School of Medicine, Zhejiang University
2018-2021
Hebei Medical University
2018
Huashan Hospital
2016
Fudan University
2016
People's Hospital of Cangzhou
2013
Home quarantine due to the global coronavirus disease 2019 (COVID-19) pandemic has had a significant impact on children. Lifestyle changes have led an increase in precocious puberty (PP) among girls, and underlying risk factors for this remain unclear. Thus, we aimed assess influence of environmental, genetic, nutritional, other lifestyle PP girls. We evaluated incidence new-onset girls during home COVID-19 analyzed potential factors. This was retrospective questionnaire medical record-based...
Introduction: To investigate the efficacy and safety of pulsatile gonadotropin-releasing hormone pump therapy in male infants with congenital hypogonadotropic hypogonadism. Methods: Seven hypogonadism who were treated a single center between 2019 2022 included. Each patient was by subcutaneous infusion 5 μg/90 min gonadorelin via for 3 to months. Data including age, drug dose, penile length, testicular volume, cryptorchidism collected. Serum testosterone, follicle-stimulating hormone,...
Background/Aims: Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic disease. This study aims to investigate whether chloride channel 2 (ClC-2) involved in high fat diet (HFD)-induced NAFLD and possible molecular mechanisms. Methods: ClC-2 expression was liver-specifically downregulated using adeno-associated virus C57BL/6 mice treated with a chow or HFD for 12 weeks. Peripheral blood tissues were collected biochemical pathological estimation respectively. Western...
OBJECTIVE: To evaluate the prevalence of Helicobacter pylori (H.pylori, HP) infection in subjects receiving routine physical examination and its associations with age, sex, body mass index (BMI) lipid profi les.MATERIALS AND METHODS: Clinical information 22,103 individuals who took examinations, including that on gender, height, weight, triglyceride, total cholesterol, high-density lipoprotein (HDL) low-density (LDL) cholesterol data HP were collected analyzed.RESULTS: H. rate taking was...
This study aims to investigate the value of high-resolution color Doppler ultrasonography (HR-CDU) in evaluation lower-extremity vasculopathy (LEV) and its related risk factors type 2 diabetes mellitus (T2DM) patients. Two hundred forty T2DM patients were selected, who underwent arterial HR-CDU. The divided into LEV group (V group) nonvasculopathy (A group). V was then mild (B group), moderate (C severe (D subgroups. relevant clinical parameters simultaneously recorded. results showed that...
To explore the clinical characteristics and genetic variants of two children with 3-hydroxy-3-methylglutaryl-coenzyme A lyase deficiency (HMGCLD).
The clinical and molecular genetic characteristics of 46,XY disorders sex development caused by NR5A1 gene variants in 15 cases were analyzed to improve the understanding this disease.
A series of m ‐ferrocenylbenzoylthiadiazole compounds, namely FcL 1 –FcL 7 , were synthesized using 3‐ferrocenylbenzoic acid and 2‐amino‐5‐aryl‐1,3,4‐thiadiazole as raw materials. These compounds characterized infrared NMR spectroscopies elemental analysis. The crystal structure was determined X‐ray diffraction. electrochemical behaviors revealed that the redox reactions on surface electrodes reversible with a single‐electron mechanism. Also, demonstrated certain responses to Pb 2+ Zn ....
Two metal–organic frameworks based on a multifunctional ligand 2-(5-bromo-pyridin-3-yl)-1H-imidazole-4,5-dicarboxylic acid (H3L), [Mn(HL)(C2H5OH)]n (1) and {[Zn(HL)(H2O)2]·H2O}n (2), have been hydro/solvothermally synthesized characterized by IR, elemental analyses, X-ray powder single-crystal diffractions, thermogravimetric analyses. In 1, (HL)2– ligands adopt the μ3-kN,O:kN′,O′:kN′′ coordination mode use their imidazoledicarboxylates to bis-chelate MnII into left- right-handed helixes...
To identify pathogenic mutation in a pedigree affected with brachydactyly and obesity.Peripheral blood sample was collected for extraction of genomic DNA. Exons capture combined next generation sequencing (NGS) carried out to potential mutation. Sanger used verify the results.NGS has identified novel heterozygous missense (c.125A>C, p.Gln42Pro) exon 1 PTHLH gene. The result verified by sequencing. mutations derived from his mother. His uncle sister have also same mutation.A gene been type E2 obesity.
To explore the genetic basis for a girl featuring bone and tooth mineralization disorder, premature deciduous teeth, rickets short stature.Genomic DNA was extracted subjected to high-throughput whole exome sequencing. Suspected variants were confirmed by Sanger Impact of potential analyzed with bioinformatic software.The child found carry compound heterozygous missense ALPL gene, including c.1130C>T (p.A377V), known pathogenic mutation inherited from her father, c.1300G>A (p.V434M) mother,...
: To analyze the clinical and genetic characteristics of children with Keishi-Bukuryo-Gan (KBG) syndrome. The data 5 KBG syndrome admitted in Children's Hospital Affiliated Zhengzhou University from November 2018 to September 2020 were retrospectively analyzed. Five all males who came four different families. All presented triangular face, bushy eyebrows, thin upper lip, large or delayed closure anterior fontanel, abnormal bone development. Four cases had growth retardation, ears, thick ear...
Objective To investigate the effect of gastrointestinal Roux-en-Y gastric bypass surgery on blood sugar and insulin function patients with type-2 diabetes mellitus.Methods Twenty-seven cases cancer undergone treatment in centre hospital Cangzhou were selected as our subject.Body mass index (BMI),Glycosylated hemoglobin (HBA1c),Fasting glucose (FPG),fasting (FINS),Fasting C-peptide (FCP) levels measured.Glucose (2 hPG),insulin hINS) hCP) detected after 2 h for oral use 75 g...
Objective To explore metabolic characteristics of and risk factors for newly diagnosed type 2 diabetes mellitus(T2DM) combined with non-alcoholic fatty liver disease (NAFLD).Methods One hundred forty-two cases T2DM were divided into two groups according to whether they have comorbid NAFLD:group A (without NAFLD,n =79) group B (combined =63).Data collected included body height,body weight,blood pressure,fasting plasma glucose (FPG),blood lipid,serum uric acid (UA),HbA1c fasting insulin,body...
Objective The present study aims to establish a professional knowledge structure for the family planning technical team at current stage in Zhejiang Province so as meet needs of training and offer reference evidences specific effective training. Methods This applied stratified cluster sampling method carry out self-administered questionnaire which was anonymous including general survey, situation training, well skill structure. This de-signed through literature review based on actual...