A5103041824- Neuroscience and Neuropharmacology Research
- Neurotransmitter Receptor Influence on Behavior
- Receptor Mechanisms and Signaling
- Supercapacitor Materials and Fabrication
- Identification and Quantification in Food
- Environmental DNA in Biodiversity Studies
- Nanoplatforms for cancer theranostics
- Adipose Tissue and Metabolism
- Advanced Nanomaterials in Catalysis
- Advancements in Battery Materials
- Fish Ecology and Management Studies
- RNA modifications and cancer
- MicroRNA in disease regulation
- Electrocatalysts for Energy Conversion
- Mitochondrial Function and Pathology
- ZnO doping and properties
- RNA Interference and Gene Delivery
- Polyoxometalates: Synthesis and Applications
- Advanced biosensing and bioanalysis techniques
- Nanoparticle-Based Drug Delivery
- Electrochemical sensors and biosensors
- Signaling Pathways in Disease
- Amino Acid Enzymes and Metabolism
- Schizophrenia research and treatment
- Ga2O3 and related materials
Beijing Jishuitan Hospital
2022-2024
National Clinical Research Center for Digestive Diseases
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2021-2024
Academy of Medical Sciences
2024
Chinese Research Academy of Environmental Sciences
2022-2024
Shenzhen Institutes of Advanced Technology
2024
Chinese Academy of Sciences
2024
Shandong University
2018-2024
Peking University
2022-2024
Jiaxing University
2023-2024
Sphingolipids have recently emerged as a biomarker of recurrence and mortality after myocardial infarction (MI). The increased ceramide levels in mammalian heart tissues during acute MI, demonstrated by several groups, is associated with higher cell death rates the left ventricle deteriorated cardiac function. Ceramidase, only enzyme known to hydrolyze proapoptotic ceramide, generates sphingosine, which then phosphorylated sphingosine kinase produce prosurvival molecule...
Currently, the limited penetration of nanoparticles remains a major challenge for antitumor nanomedicine to penetrate into tumor tissues. Herein, we propose size-shrinkable drug delivery system based on polysaccharide-modified dendrimer with microenvironment responsiveness first time our knowledge, which was formed by conjugating terminal glucose hyaluronic acid (HA) superficial amidogen poly(amidoamine) (PAMAM), using matrix metalloproteinase-2 (MMP-2)-cleavable peptide (PLGLAG) via click...
Vitiligo is a cutaneous depigmenting autoimmune disease caused by the extensive destruction of epidermal melanocytes. Convincing data has defined critical role for oxidative stress in pathogenesis vitiligo. Oxeiptosis caspase-independent cell death modality that was reportedly triggered and operative pathogen clearance. However, whether oxeiptosis exists stress-induced melanocytes demise vitiligo remains undetermined. In present study, we initially found other modalities might exist addition...
To evaluate the postulated role of extrastriatal D 1 receptors in human cognition and psychopathology requires an accurate reliable method for quantification these living brain. [ 11 C]NNC 112 is a promising novel radiotracer positron emission tomography imaging receptor. The goal this study was to develop methods derive receptor parameters striatal regions brain with 112. Six healthy volunteers were studied twice. Two analysis (kinetic graphical) applied 12 (neocortical, limbic, subcortical...
Multidrug resistance (MDR) is the major obstacle for chemotherapy. In a previous study, we have successfully synthesized novel doxorubicin (DOX) derivative modified by triphenylphosphonium (TPP) to realize mitochondrial delivery of DOX and showed potential this compound overcome in MDA-MB-435/DOX cells.(1) To introduce specificity DOX-TPP cancer cells, here report on conjugation hyaluronic acid (HA) hydrazone bond with adipic dihydrazide (ADH) as acid-responsive linker, producing...
Fish diversity, an important indicator of the health aquatic ecosystems, is declining sharply due to water pollution, overfishing, climate change, and species invasion. For protecting fish effective surveying monitoring are prerequisites. In this study, eDNA (environmental DNA) metabarcoding ground cages were used survey diversity Chaobai Beiyun Rivers in Beijing. Based on two methods, we identified 40 species, belonging 35 genera, 18 families, six orders. The richness by was significantly...
Induced pluripotent stem cells (iPSCs) are a promising melanocyte source as they propagate indefinitely and can be established from patients. However, the in vivo functions of human iPSC-derived melanocytes (hiMels) remain unknown. Here, we generated hiMels vitiligo patients using three-dimensional system with enhanced differentiation efficiency, which showed characteristics epidermal high sequence similarity involved multiple vitiligo-associated signaling pathways. A modified hair follicle...
On account of the biological significance self-assembling peptides in blocking cellular mass exchange as well impeding formation for actin filaments resulting program cell death, stimuli-responsive polypeptide nanoparticles have attracted more and attention. In this work, we successfully fabricated doxorubicin-loaded polyethylene glycol-block-peptide (FFKY)-block-tetraphenylethylene (PEG-Pep-TPE/DOX) nanoparticles, where aggregation-induced emission luminogens (AIEgen, TPE-CHO) can become a...
Self-assembled peptide nanofibers have been widely studied in cancer nanotherapeutics with their excellent biocompatibility and low toxicity of degradation products, showing the significant potential inhibiting tumor progression. However, poor solubility prevents direct intravenous administration nanofibers. Although water-soluble precursors formed via method phosphorylation for administration, opportunities broad vivo application are limited by weak capacity encapsulating drugs. Herein, we...