A5101636708- melanin and skin pigmentation
- Atherosclerosis and Cardiovascular Diseases
- Skin Protection and Aging
- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- Cancer-related molecular mechanisms research
- Cancer, Lipids, and Metabolism
- Herpesvirus Infections and Treatments
- interferon and immune responses
- Renal cell carcinoma treatment
- Cancer, Hypoxia, and Metabolism
- MicroRNA in disease regulation
- Gout, Hyperuricemia, Uric Acid
- Menopause: Health Impacts and Treatments
- Inflammasome and immune disorders
- Autophagy in Disease and Therapy
- Phytochemicals and Antioxidant Activities
- Epigenetics and DNA Methylation
- Pharmacogenetics and Drug Metabolism
- Circular RNAs in diseases
- Tannin, Tannase and Anticancer Activities
- Garlic and Onion Studies
- Drug Transport and Resistance Mechanisms
- Estrogen and related hormone effects
- Mast cells and histamine
Southern University of Science and Technology
2021-2024
Air Force Medical University
2019-2024
Xijing Hospital
2019-2024
Shandong Provincial Hospital
2023
Shandong First Medical University
2023
Sun Yat-sen University
2022-2023
The First Affiliated Hospital, Sun Yat-sen University
2022-2023
Chung Shan Medical University
2018
Vitiligo is a cutaneous depigmenting autoimmune disease caused by the extensive destruction of epidermal melanocytes. Convincing data has defined critical role for oxidative stress in pathogenesis vitiligo. Oxeiptosis caspase-independent cell death modality that was reportedly triggered and operative pathogen clearance. However, whether oxeiptosis exists stress-induced melanocytes demise vitiligo remains undetermined. In present study, we initially found other modalities might exist addition...
Abstract Circular RNAs (circRNAs) play critical roles in clear cell renal carcinoma (ccRCC). However, their involvement sunitinib resistance remains largely unknown. Herein, we identified a novel circRNA, named circME1, which contributes to development ccRCC. CircME1 also promoted proliferation, migration, and invasion of ccRCC cells. Further mechanism analysis showed that circME1 interacted with U1 snRNP at the promoter its parental gene ME1, thereby upregulating expression enhancing...
Clear cell renal carcinoma (ccRCC) is a highly invasive and metastatic subtype of kidney malignancy correlated with metabolic reprogramming for adaptation to the tumor microenvironment comprising infiltrated immune cells immunomodulatory molecules. The role in (TME) their association abnormal fatty acids metabolism ccRCC remains poorly understood. RNA-seq clinical data KIRC from Cancer Genome Atlas (TCGA) E-MTAB-1980 ArrayExpress dataset. Nivolumab group Everolimus CheckMate 025 study,...
Abstract Vitiligo is a depigmented skin disease due to the destruction of melanocytes. Under oxidative stress, keratinocyte‐derived chemokine C‐X‐C motif ligand 16 (CXCL16) plays critical role in recruiting CD8 + T cells, which kill Autophagy serves as protective cell survival mechanism and impairment autophagy has been linked increased secretion proinflammatory cytokines. However, CXCL16 under stress not investigated. Herein, we initially found that was suppressed both keratinocytes...
Autoimmune diseases are increasingly linked to aberrant gut microbiome and relevant metabolites. However, the association between vitiligo remains be elucidated. Thus, we conducted a case-control study through 16S rRNA sequencing serum untargeted-metabolomic profiling based on 30 patients matched healthy controls. In patients, microbial composition was distinct from that of controls according analysis α- β-diversity ( P < 0.05), with characteristic decreased Bacteroidetes: Firmicutes...
The activation of NLRP3 inflammasome-IL-1β pathway in keratinocytes contributes to the melanocyte death via autoimmunity-dependent manner vitiligo. As a safe small-compound drug employed frequently clinic, tranilast (TR) is newly reported block inflammasome macrophage. Nevertheless, whether keratinocyte-derived IL-1β damages melanocytes an autoimmunity-independent way and TR could ameliorate damage inhibiting NLRP3-IL-1β keratinocyte still are not clear. In present study, we initially found...
Pyroptosis or cellular inflammatory necrosis is a programmed cell death kind. Accumulating evidence shows that pyroptosis plays crucial role in the invasion, metastasis, and proliferation of tumor cells, thus affecting prognosis tumors therapeutic effects. Prostate cancer (PCa), common malignancy among men, associated with inflammation. Pathophysiological effects on development progression, as well mediation PCa, are known, but its potential for PCa warrant in-depth investigation. Herein, we...
Studies demonstrate that long non-coding RNAs (lncRNAs) play vital roles in cancer progression. However, the expression pattern and molecular mechanisms of lncRNA FAM83A-AS1 lung remain largely unclear. Here, we analyzed tissues from three RNA-sequencing (RNA-Seq) datasets validated these results using quantitative real-time reverse transcription polymerase chain reaction (qRT-PCR) an independent set adenocarcinoma. Cell proliferation, migration, invasion, autophagy were after knockdown with...
Abstract Vitiligo is a disfiguring disease featuring chemokines-mediated cutaneous infiltration of autoreactive CD8 + T cells that kill melanocytes. Copious studies have indicated virus invasion participates in the pathogenesis vitiligo. IFIH1 , encoding MDA5 which an intracellular sensor, has been identified as vitiligo susceptibility gene. However, specific role melanocyte death under not clear. In this study, we first showed expression anti-CMV IgM and was higher patients than healthy...
Abstract In vitiligo, autoreactive CD8 + T cells have been established as the main culprit considering its pathogenic role in mediating epidermal melanocyte‐specific destruction. Macrophage migration inhibitory factor (MIF) is a pleiotropic molecule that plays central various immune processes including activation and proliferation of cells; but whether MIF intertwined vitiligo development progression involvement aberrantly activated remains ill‐defined. this study, we found was overabundant...
Abstract Background Studies demonstrate that long non-coding RNAs (lncRNAs) play critical roles in the occurrence and development of cancer. However, many molecular mechanisms underlying lncRNAs role this process remains unclear. Methods Here, we analyzed lncRNA expression lung cancer tissues based on RNA-Seq analysis found FAM83A-AS1 was one top up-regulated adenocarcinoma elevated significantly associated with poor patient survival. We validated these results using RT-PCR an independent...
Abstract Background： Clear cell renal carcinoma (ccRCC) is a highly invasive and metastatic subtype of kidney malignancy correlated with metabolic reprogramming for adaptation to the tumor microenvironment comprising infiltrated immune cells immunomodulatory molecules. The role in (TME) their association abnormal fatty acids metabolism ccRCC remain poorly understood. Method: Data from TGCA-KIRC, E-MTAB-1980, CheckMate-025, IMmotion150 IMmotion151 cohort were obtained subsequent analysis....
During the transition from a reproductive to nonreproductive phase (menopause), many women experience significant physiological and pathological changes, including decreased bone mass, increased blood lipids, visceral adiposity. Levels of follicle-stimulating hormone (FSH) rise during menopausal transition. Many studies have shown that FSH in various extragonadal tissues organs is associated with pathogenesis multiple diseases. Thus, building an animal model can help study independent...